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dc.contributor.advisorBayer, Annette
dc.contributor.authorAbdelhady, Ahmed Mossad Mohamed
dc.date.accessioned2019-05-29T11:31:32Z
dc.date.available2019-05-29T11:31:32Z
dc.date.issued2016-05-18
dc.description.abstractBreitfussins are a group of a closely related heterocyclic compounds. They consist of a tetracyclic structure with an indole, an oxazole and a pyrrole. The breitfussins exhibit interesting biological activity and analogues synthesis and biological evaluation is ongoing. Phorbazoles have a structural similarity with breitfussins in which a phenol replaces the indole. As a part of this, synthesis of phorbazoles, breitfussins and analogues is underway in the Bayer group. This thesis contains a description for the work done to synthesis a small library of a small group of phorbazoles analogues and one breitfussins analogue. During the synthesis of the phorbazoles analogues, an isocyanide based oxazole synthesis was performed using TosMIC. Iodination of the oxazole was tested with different approaches to obtain 2,4-diiodinated and 2-iodinated oxazole derivatives. For introducing a Pyrrole on the oxazole, a Suzuki-Miyaura cross coupling reaction was performed. As a final step, selective de-protections were performed to obtain the diversity of the analogues. The breitfussins analogue was formed in 2 steps from the commercially available starting material, methyl-1H-indole-3-carboxylate 13.en_US
dc.identifier.urihttps://hdl.handle.net/10037/15400
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2016 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)en_US
dc.subject.courseIDKJE-3900
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440en_US
dc.titleSynthesis of phorbazoles and breitfussins analoguesen_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)
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