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dc.contributor.authorPatra, Ashis K.
dc.contributor.authorDube, Koustubh S.
dc.contributor.authorSanders, Brian C.
dc.contributor.authorPapaefthymiou, Georgia C.
dc.contributor.authorConradie, Jeanet
dc.contributor.authorGhosh, Abhik
dc.contributor.authorHarrop, Todd C.
dc.date.accessioned2020-02-03T10:11:19Z
dc.date.available2020-02-03T10:11:19Z
dc.date.issued2012-10-06
dc.description.abstractReduced nitrogen oxide ligands such as NO<sup>−</sup>/HNO or nitroxyl participate in chemistry distinct from nitric oxide (NO). Nitroxyl has been proposed to form at heme centers to generate the Enemark–Feltham designated {FeNO}<sup>8</sup> system. The synthesis of a thermally stable {FeNO}<sup>8</sup> species namely, [Co(Cp<sup>*</sup>)<sub>2</sub>][Fe(LN<sub>4</sub>)(NO)] (3), housed in a heme-like ligand platform has been achieved by reduction of the corresponding {FeNO}<sup>7</sup> complex, [Fe(LN<sub>4</sub>)(NO)] (1), with decamethylcobaltocene [Co(Cp<sup>*</sup>)<sub>2</sub>] in toluene. This complex readily reacts with metMb, resulting in formation of MbNO via reductive nitrosylation by the coordinated HNO/NO<sup>−</sup>, which can be inhibited with GSH. These results suggest that 3 could serve as a potential HNO therapeutic. Spectroscopic, theoretical, and structural comparisons are made to 1 and the {CoNO}<sup>8</sup> complex, [Co(LN<sub>4</sub>)(NO)] (2), an isoelectronic analogue of 3.en_US
dc.identifier.citationPatra, Dube, Sanders, Papaefthymiou, Conradie J, Ghosh A, Harrop. A thermally stable {FeNO}(8) complex: properties and biological reactivity of reduced MNO systems. Chemical Science. 2012;3(2):364-369en_US
dc.identifier.cristinIDFRIDAID 924358
dc.identifier.doi10.1039/c1sc00582k
dc.identifier.issn2041-6520
dc.identifier.issn2041-6539
dc.identifier.urihttps://hdl.handle.net/10037/17301
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.journalChemical Science
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/SFF/179568/Norway/Centre for Theoretical and Computational Chemistry/CTCC/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440::Organic chemistry: 441en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Organisk kjemi: 441en_US
dc.titleA thermally stable {FeNO}(8) complex: properties and biological reactivity of reduced MNO systemsen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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