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dc.contributor.authorElumalai, Vijayaragavan
dc.contributor.authorHansen, Jørn H
dc.date.accessioned2020-12-04T09:51:16Z
dc.date.available2020-12-04T09:51:16Z
dc.date.issued2020-11-07
dc.description.abstractA mild, green and highly efficient protocol was developed for the synthesis of substituted phenols via <i>ipso</i>-hydroxylation of arylboronic acids in ethanol. The method utilizes the combination of aqueous hydrogen peroxide as the oxidant and H<sub>2</sub>O<sub>2</sub>/HBr as the reagent under unprecedentedly simple and convenient conditions. A wide range of arylboronic acids were smoothly transformed into substituted phenols in very good to excellent yields without chromatographic purification. The reaction is scalable up to at least 5 grams at room temperature with one-minute reaction time and can be combined in a one-pot sequence with bromination and Pd-catalyzed cross-coupling to generate more diverse, highly substituted phenols.en_US
dc.identifier.citationElumalai V, Hansen JHH. A scalable and green one-minute synthesis of substituted phenols. RSC Advances. 2020;10:40582en_US
dc.identifier.cristinIDFRIDAID 1854535
dc.identifier.doi10.1039/D0RA08580D
dc.identifier.issn2046-2069
dc.identifier.urihttps://hdl.handle.net/10037/19987
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.journalRSC Advances
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRINATEK/ProjectNumber/275043/CasCat: Cascade Catalysis for Late-Stage C-H Functionalization//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440en_US
dc.titleA scalable and green one-minute synthesis of substituted phenolsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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