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dc.contributor.authorvan der Valk, Tom
dc.contributor.authorPečnerová, Patrícia
dc.contributor.authorDíez-del-Molino, David
dc.contributor.authorBergström, Anders
dc.contributor.authorOppenheimer, Jonas
dc.contributor.authorHartmann, Stefanie
dc.contributor.authorXenikoudakis, Georgios
dc.contributor.authorThomas, Jessica A.
dc.contributor.authorDehasque, Marianne
dc.contributor.authorSağlıcan, Ekin
dc.contributor.authorRabia Fidan, Fatma
dc.contributor.authorBarnes, Ian
dc.contributor.authorLiu, Shanlin
dc.contributor.authorSomel, Mehmet
dc.contributor.authorHeintzman, Peter D.
dc.contributor.authorNikolskiy, Pavel
dc.contributor.authorShapiro, Beth
dc.contributor.authorSkoglund, Pontus
dc.contributor.authorHofreiter, Michael
dc.contributor.authorLister, Adrian M.
dc.contributor.authorGötherström, Anders
dc.contributor.authorDalén, Love
dc.date.accessioned2022-03-23T12:36:50Z
dc.date.available2022-03-23T12:36:50Z
dc.date.issued2021-02-17
dc.description.abstractTemporal genomic data hold great potential for studying evolutionary processes such as speciation. However, sampling across speciation events would, in many cases, require genomic time series that stretch well back into the Early Pleistocene subepoch. Although theoretical models suggest that DNA should survive on this timescale1, the oldest genomic data recovered so far are from a horse specimen dated to 780–560 thousand years ago2. Here we report the recovery of genome-wide data from three mammoth specimens dating to the Early and Middle Pleistocene subepochs, two of which are more than one million years old. We find that two distinct mammoth lineages were present in eastern Siberia during the Early Pleistocene. One of these lineages gave rise to the woolly mammoth and the other represents a previously unrecognized lineage that was ancestral to the first mammoths to colonize North America. Our analyses reveal that the Columbian mammoth of North America traces its ancestry to a Middle Pleistocene hybridization between these two lineages, with roughly equal admixture proportions. Finally, we show that the majority of protein-coding changes associated with cold adaptation in woolly mammoths were already present one million years ago. These findings highlight the potential of deep-time palaeogenomics to expand our understanding of speciation and long-term adaptive evolution.en_US
dc.identifier.citationvan der Valk T, Pečnerová, Díez-del-Molino D, Bergström A, Oppenheimer J, Hartmann S, Xenikoudakis G, Thomas, Dehasque M, Sağlıcan, Rabia Fidan, Barnes I, Liu S, Somel M, Heintzman PD, Nikolskiy, Shapiro B, Skoglund P, Hofreiter M, Lister AM, Götherström A, Dalén L. Million-year-old DNA sheds light on the genomic history of mammoths. Nature. 2021;591:265-269en_US
dc.identifier.cristinIDFRIDAID 1929069
dc.identifier.doi10.1038/s41586-021-03224-9
dc.identifier.issn0028-0836
dc.identifier.issn1476-4687
dc.identifier.urihttps://hdl.handle.net/10037/24516
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalNature
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleMillion-year-old DNA sheds light on the genomic history of mammothsen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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