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dc.contributor.authorWarshan, Denis
dc.contributor.authorLiaimer, Anton
dc.contributor.authorPederson, Eric
dc.contributor.authorKim, Sea-Yong
dc.contributor.authorShapiro, Nicole
dc.contributor.authorWoyke, Tanja
dc.contributor.authorAltermark, Bjørn
dc.contributor.authorPawlowski, Katharina
dc.contributor.authorWeyman, Philip D.
dc.contributor.authorDupont, Christopher L.
dc.contributor.authorRasmussen, Ulla
dc.date.accessioned2022-04-27T10:56:59Z
dc.date.available2022-04-27T10:56:59Z
dc.date.issued2018-03-15
dc.description.abstractCyanobacteria belonging to the genus Nostoc comprise free-living strains and also facultative plant symbionts. Symbiotic strains can enter into symbiosis with taxonomically diverse range of host plants. Little is known about genomic changes associated with evolutionary transition of Nostoc from free-living to plant symbiont. Here, we compared the genomes derived from 11 symbiotic Nostoc strains isolated from different host plants and infer phylogenetic relationships between strains. Phylogenetic reconstructions of 89 Nostocales showed that symbiotic Nostoc strains with a broad host range, entering epiphytic and intracellular or extracellular endophytic interactions, form a monophyletic clade indicating a common evolutionary history. A polyphyletic origin was found for Nostoc strains which enter only extracellular symbioses, and inference of transfer events implied that this trait was likely acquired several times in the evolution of the Nostocales. Symbiotic Nostoc strains showed enriched functions in transport and metabolism of organic sulfur, chemotaxis and motility, as well as the uptake of phosphate, branched-chain amino acids, and ammonium. The genomes of the intracellular clade differ from that of other Nostoc strains, with a gain/enrichment of genes encoding proteins to generate l-methionine from sulfite and pathways for the degradation of the plant metabolites vanillin and vanillate, and of the macromolecule xylan present in plant cell walls. These compounds could function as C-sources for members of the intracellular clade. Molecular clock analysis indicated that the intracellular clade emerged ca. 600 Ma, suggesting that intracellular Nostoc symbioses predate the origin of land plants and the emergence of their extant hosts.en_US
dc.identifier.citationWarshan, Liaimer A, Pederson, Kim, Shapiro N, Woyke T, Altermark B, Pawlowski, Weyman, Dupont, Rasmussen U. Genomic Changes Associated with the Evolutionary Transitions of Nostoc to a Plant Symbiont. Molecular Biology and Evolution (MBE). 2018;35(5):1160-1175en_US
dc.identifier.cristinIDFRIDAID 1581751
dc.identifier.doi10.1093/molbev/msy029
dc.identifier.issn0737-4038
dc.identifier.issn1537-1719
dc.identifier.urihttps://hdl.handle.net/10037/24910
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalMolecular Biology and Evolution (MBE)
dc.relation.projectIDNASA National Aeronautics and Space Administration: Project fundingen_US
dc.relation.projectIDNASA National Aeronautics and Space Administration: PROJECT FUNDINGen_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2018 The Author(s)en_US
dc.titleGenomic Changes Associated with the Evolutionary Transitions of Nostoc to a Plant Symbionten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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