Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences
Permanent lenke
https://hdl.handle.net/10037/34859Dato
2024-01-12Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Yu, Daqi; Ren, Yandong; Uesaka, Masahiro; Beavan, Alan; Muffato, Matthieu; Shen, Jieyu; Li, Yongxin; Sato, Iori; Wan, Wenting; Clark, James; Keating, Joseph; Carlisle, Emily; Dearden, Richard; Giles, Sam; Randle, Emma; Sansom, Robert; Feuda, Roberto; Fleming, James Frederick; Sugahara, Fumiaki; Cummins, Carla; Patricio, Mateus; Akanni, Wasiu; D'Aniello, Salvatore; Bertolucci, Christiano; Irie, Naoki; Alev, Cantas; Sheng, Guojun; de Mendoza, Alex; Maeso, Ignacio; Irimia, Manuel; Fromm, Bastian; Peterson, Kevin J; Das, Sabyasachi; Hirano, Masayuki; Rast, Jonathan P; Cooper, Max; Paps, Jordi; Pisani, Davide; Kuratani, Shigeru; Martin, Fergal J.; Wang, Wen; Donoghue, Philip C J; Zhang, Yong E.; Pascual-Anaya, JuanSammendrag
Polyploidy or whole-genome duplication (WGD) is a major event that
drastically reshapes genome architecture and is often assumed to be
causally associated with organismal innovations and radiations. The 2R
hypothesis suggests that two WGD events (1R and 2R) occurred during
early vertebrate evolution. However, the timing of the 2R event relative
to the divergence of gnathostomes ( jawed vertebrates) and cyclostomes
( jawless hagfishes and lampreys) is unresolved and whether these WGD
events underlie vertebrate phenotypic diversification remains elusive.
Here we present the genome of the inshore hagfish, Eptatretus burgeri.
Through comparative analysis with lamprey and gnathostome genomes,
we reconstruct the early events in cyclostome genome evolution, leveraging
insights into the ancestral vertebrate genome. Genome-wide synteny
and phylogenetic analyses support a scenario in which 1R occurred in the
vertebrate stem-lineage during the early Cambrian, and 2R occurred in
the gnathostome stem-lineage, maximally in the late Cambrian–earliest
Ordovician, after its divergence from cyclostomes. We fnd that the genome
of stem-cyclostomes experienced an additional independent genome
triplication. Functional genomic and morphospace analyses demonstrate
that WGD events generally contribute to developmental evolution with
similar changes in the regulatory genome of both vertebrate groups.
However, appreciable morphological diversification occurred only in the
gnathostome but not in the cyclostome lineage, calling into question the
general expectation that WGDs lead to leaps of bodyplan complexity.
Forlag
Springer NatureSitering
Yu, Ren Y, Uesaka, Beavan A, Muffato M, Shen, Li Y, Sato, Wan W, Clark J, Keating, Carlisle, Dearden, Giles, Randle, Sansom, Feuda R, Fleming JF, Sugahara, Cummins, Patricio M, Akanni W, D'Aniello S, Bertolucci, Irie N, Alev C, Sheng G, de Mendoza A, Maeso I, Irimia M, Fromm B, Peterson KJ, Das, Hirano, Rast JP, Cooper, Paps J, Pisani D, Kuratani, Martin FJ, Wang W, Donoghue PCJ, Zhang YE, Pascual-Anaya J. Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences. Nature Ecology and Evolution. 2024Metadata
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