Artikler, rapporter og annet (farmasi): Nye registreringer
Viser treff 281-300 av 358
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Chronic Responses of Daphnia magna under Dietary Exposure to Leaves of a Transgenic (Event MON810) Bt-Maize Hybrid and its Conventional Near-Isoline
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-11)Insect resistance is the second most common trait globally in cultivated genetically modified (GM) plants. Resistance is usually obtained by introducing into the plant’s genome genes from the bacterium Bacillus thuringiensis (Bt) coding for insecticidal proteins (Cry proteins or toxins) that target insect pests. The aim of this study was to examine the hypothesis that a chronic, high-dose dietary ... -
Involvement of aph(3')-IIa in the formation of mosaic aminoglycoside resistance genes in natural environments
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-19)Intragenic recombination leading to mosaic gene formation is known to alter resistance profiles for particular genes and bacterial species. Few studies have examined to what extent aminoglycoside resistance genes undergo intragenic recombination. We screened the GenBank database for mosaic gene formation in homologs of the aph(3′)-IIa (nptII) gene. APH(3′)-IIa inactivates important aminoglycoside ... -
Biomimetic PVPA in vitro model for estimation of the intestinal drug permeability using fasted and fed state simulated intestinal fluids
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-20)A prerequisite for successful oral drug therapy is the drug’s ability to cross the gastrointestinal barrier. Considering the increasing number of new chemical entities in modern drug discovery, reliable and fast in vitro models are required for early and efficient prediction of intestinal permeability. To mimic the intestinal environment, use of biorelevant media may provide valuable information ... -
Drug permeability across a phospholipid vesicle-based barrier - 2. Characterization of barrier structure, storage stability and stability towards pH changes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2006-04-18)Recently we reported on the development of a phospholipid vesicle-based barrier as a medium throughput method for screening of drug permeability. The aim of this present study is to characterize the barrier structure, including an estimation of the amount of phospholipid within it, its storage stability and its stability over various pH ranges found in different parts of the gastrointestinal tract. ... -
In vitro skin models as a tool in optimization of drug formulation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-30)(Trans)dermal drug therapy is gaining increasing importance in the modern drug development. To fully utilize the potential of this route, it is important to optimize the delivery of active ingredient/drug into/through the skin. The optimal carrier/vehicle can enhance the desired outcome of the therapy therefore the optimization of skin formulations is often included in the early stages of the ... -
The Phospholipid Vesicle-Based Drug Permeability Assay: 5. Development Toward an Automated Procedure for High-Throughput Permeability Screening
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009-02)In-vitro screening for oral absorption has become an essential part of drug discovery and development. Recently, a new phospholipid vesicle-based permeation assay was developed which has shown to satisfyingly predict passive absorption of drugs in humans. The purpose of the current study was to investigate whether the assay may be further developed into a high-throughput tool by automating its ... -
Antibiotic delivery by liposomes from prokaryotic microorganisms: Similia cum similis works better
(Journal article; Preprint; Tidsskriftartikkel; Peer reviewed; Manuskript, 2015-06-25)To date the effectiveness of antibiotics is undermined by microbial resistance, threatening public health worldwide. Enhancing the efficacy of the current antibiotic arsenal is an alternative strategy. The administration of antimicrobials encapsulated in nanocarriers, such as liposomes, is considered a viable option, though with some drawbacks related to limited affinity between conventional liposomes ... -
Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-07)Resveratrol (RES), chemically known as 3,5,4′-trihydroxy-trans-stilbene, is a promising multi-targeted antioxidative and anti-inflammatory natural polyphenol. Preclinical studies showed its biological activities against the pathogens of sexually transmitted diseases causing vaginal inflammation and infections. Due to its low solubility and poor bioavailability, the optimal therapeutic uses are ... -
Comorbidities in an asthma population 8-29 years old: a study from the Norwegian Prescription Database
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011-09-23)Purpose: To examine occurrence of chronic diseases and antimicrobial treatment in an asthma population 8-29 years old, compared to the general population. Methods: In this cross-sectional study, the asthma population was identified from the general population (retrieved from a census covering the entire Norwegian population) by using filled prescriptions on asthma drugs as a proxy measure of ... -
Prescribing of drugs for attention-deficit hyperactivity disorder in opioid maintenance treatment patients in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-09-27)Background: Attention-deficit hyperactivity disorder (ADHD) is a risk factor for development of substance use disorders. Treatment of ADHD with psychostimulants in patients on opioid maintenance treatment (OMT) has been restricted in Norway. We examined use of prescribed drugs for ADHD in OMT patients, and assessed co-medication with other psychotropics. Methods: Data were drawn from the nationwide ... -
Ny diagnostikk for Alzheimers i Nytt Senter
(Chronicle; Kronikk, 2015-04-23) -
Longitudinal magnetic resonance imaging-based assessment of vascular changes and radiation response in androgen-sensitive prostate carcinoma xenografts under androgen-exposed and androgen-deprived conditions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010-10)Prostate cancer (PCa) patients receive androgen-deprivation therapy (ADT) to reduce tumor burden. However, complete eradication of PCa is unusual, and recurrent disease is evident within approximately 2 years in high-risk patients. Clinical evidence suggests that combining ADT with radiotherapy improves local control and disease-free survival in these patients compared with radiotherapy alone. ... -
The German ban on GM maize MON810: scientifically justified or unjustified?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012) -
A pharmacist-led follow-up program for patients with coronary heart disease in North Norway-a qualitative study exploring patient experiences
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Scientific Opinion on applications (EFSA-GMO-UK-2008-57 and EFSA-GMO-RX-MON15985) for the placing on the market of insect-resistant genetically modified cotton MON 15985 for food and feed uses, import and processing, and for the renewal of authorisation of existing products produced from cotton MON 15985, both under Regulation (EC) No 1829/2003 from Monsanto
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Statement complementing the EFSA opinion on application EFSA GMO UK 2007 41 (cotton MON 88913 for food and feed uses, import and processing) taking into consideration updated bioinformatic analyses
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Scientific Opinion on application (EFSA-GMO-NL-2010-77) for the placing on the market of herbicide-tolerant genetically modified cotton GHB614 × LLCotton25 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Bayer CropScience
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Scientific Opinion on the annual post-market environmental monitoring (PMEM) report from Monsanto Europe S.A. on the cultivation of genetically modified maize MON 810 in 2012
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Mucoadhesive liposomes as new formulation for vaginal delivery of curcumin
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Development of a biomimetic phospholipid vesicle-based permeation assay for the estimation of intestinal drug permeability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)