Mastergradsoppgaver i farmasi: Recent submissions

Now showing items 1-20 of 294

    • The effect of β-lactamase evolution on biofilm formation in Vibrio cholerae 

      Haukefer, Anne Sofie Bernhardsen (Master thesis; Mastergradsoppgave, 2023-05-15)
      Antimicrobial resistance (AMR) has emerged as one of the greatest threats to public health in the 21st century. Especially, the production of -lactamase enzymes has become the leading cause of -lactam resistance in Gram-negative pathogens. In addition, many of the pathogens associated with extensive antimicrobial resistance form biofilms, which further increases their persistence. Studies from ...

    • Kvalitet av legemiddelbruk og legemiddelinformasjon hos hoftebruddspasienter ved Sykehuset i Vestfold HF – en tverrsnittstudie 

      Nguyen, Caroline Thy (Master thesis; Mastergradsoppgave, 2019-05-15)
      Det er i hovedsak eldre personer som gjennomgår hoftebrudd, som er et fryktet osteoporotisk brudd. Eldre har flere sykdommer som fører til at de blir behandlet med flere legemidler sammenlignet med yngre. Dette vil igjen øke risikoen for uhensiktsmessig legemiddelbruk. I tillegg overføres eldre hyppig inn og ut og mellom helseinstitusjoner, som skaper et behov for velfungerende informasjonsoverføring. ...

    • Dual delivery of chlorogenic acid and mimic of antimicrobial peptide – towards wound treatment 

      Salamonsen, Mari (Master thesis; Mastergradsoppgave, 2022-05-12)
      Chronic wounds are a major burden, causing both morbidity and mortality in patients, as well as a massive economical strain on health care systems worldwide. These wounds have a high degree of complexity and are often difficult to treat due to the many factors limiting healing, such as inflammation, biofilm formation and bacterial infections. With these typically persistent infections and a rising ...

    • Chitosan-modified liposomes for delivery of membrane-active antimicrobials – exploring the role of the polymer 

      Panchai, Pimmat (Master thesis; Mastergradsoppgave, 2022-05-12)
      Antimicrobial resistance in skin injury infections is becoming a rising problem as more conventional antimicrobials become ineffective in resistant infections. Therefore, developing novel effective antimicrobials while promoting wound healing is urgently needed. Membrane-active antimicrobials, such as antimicrobial peptides (AMPs), display promising antimicrobial activity, and could potentially solve ...

    • Using High-Resolution Mass Spectrometry to identify lipids in marine bacterial biomass 

      Laugsand, Gøril (Mastergradsoppgave; Master thesis, 2023-05-14)
      Background: BMFishfeed is a cooperative project since 2021 between UiT the Arctic University of Norway, NORCE Stavanger and the University of South-Eastern Norway where the goal is to develop a lipid-rich bacterial meal that can be utilized as fish feed in the aquaculture industry. Carbon-rich waste from an omega-3 production site is used as nutrition for marine bacterial cultures, which are fermented ...

    • Process optimization of albumin-stabilized mitotane nanoparticle preparation by dual centrifugation and first lyophilization study 

      Zhang, Cindy Jia Ru (Mastergradsoppgave; Master thesis, 2022-05-13)
      Albumin-stabilized mitotane nanoparticles intended for intravenous application can serve as a potential formulation for the treatment of adrenocortical carcinoma. However, the particle size of a nanoparticle-based formulation is crucial for the in vivo behavior of the nanoparticles following an intravenous injection. Prior to this project, the particle size of this nanoformulation had a mean of ...

    • Push and pull factors for migration of foreign pharmacists to Norway 

      Iqbal, Saleem (Mastergradsoppgave; Master thesis, 2022-05-12)
      Migration of foreign pharmacists to Norway has increased considerably in recent years. Data from the Directorate of Health shows that 1592 foreign pharmacists received authorization in Norway from 2013 to 2021 as compared to 1952 Norwegian pharmacists. There are several theories of migration, but “push and pull theory” is the most widely used approach to learn about reasons of migration. According ...

    • Computational studies on the human GnRH-I and the GnRH-receptor 

      Tran, Anton (Mastergradsoppgave; Master thesis, 2022-05-12)
      Gonadotropin-releasing hormone receptor (GnRH-R), which is a Class A G-protein coupled receptor (GPCR), has a vital role in the regulation of sex hormones. The receptor also has a prominent role in diseases, with examples being reproductive cancers and non-reproductive cancers like glioblastoma. Gonadotropin-releasing hormone (GnRH) agonists have been proven to combat cell proliferation in cancers. ...

    • The productivity gain by preventing first and subsequent hip fractures in osteoporotic patients as a result of optimal treatment 

      Aamodt, Martin Arvin (Mastergradsoppgave; Master thesis, 2022-05-11)
      Background: Preventing hip fractures could prevent patient disability and premature death, and lead to substantial societal savings in terms of productivity gains. However, the Norwegian government has decided against emphasizing productivity gains in prioritization decisions for financing pharmaceutical drugs. The question, however, remains whether including productivity gains could lead to better ...

    • Medicine articles on English Wikipedia: Quantifying the presence of pharmaceutical industry edits and analyzing their content. 

      Jadgal, Asia (Mastergradsoppgave; Master thesis, 2022-05-11)
      Today, Wikipedia has developed into a prominent source for health queries to the vast public. Over the years, some studies have been performed to understand what the webpage can and cannot offer. However, the current literature lacks knowledge of how the pharmaceutical industry is present in Wikipedia’s medicine articles. The immediate objective of this research was to quantify the presence of ...

    • Development of DNA Nanoparticles with Properties for Enhanced Biofilm Uptake 

      Borøy, Vegard (Mastergradsoppgave; Master thesis, 2022-05-11)
      Microbial biofilms account for up to 80% of all bacterial infections. They are described as small structural communities of bacteria which are embedded in a self-produced extracellular (EPS) matrix. This EPS matrix poses a substantial challenge for antimicrobial treatment by hindering traversal of antimicrobial agents. Nanotechnology based drug delivery systems (DDS) offer a promising solution ...

    • Hvilke tanker og erfaringer har leger rundt korrekt legemiddelliste og legemiddelbruk til pasienter i akuttmottak? Og hvordan ser de for seg et fremtidig samarbeid med farmasøyt? 

      Fjellstad, Elaine (Mastergradsoppgave; Master thesis, 2020-08-01)
      BAKGRUNN: Legemiddelfeil er et utbredt problem både internasjonalt og nasjonalt, dette kan medfører risiko for pasientsikkerheten. Kliniske farmasøyter er bedre til å oppdage potensielt klinisk relevante uoverensstemmelser enn leger og er blitt mer utbredt på sykehus. De er foreløpig er ikke vanlig på akuttmottak i Norge i motsetning til i andre land. FORMÅL: Formålet med studien er å undersøke ...

    • Fall hos ortopediske pasienter – sammenligning av to fallscreeningverktøy 

      Fossum, Regine Lidtveit (Master thesis; Mastergradsoppgave, 2022-05-12)
      Bakgrunn og formål: Fall er en av de vanligste rapportere uheldige hendelsene på sykehus. Fall medfører betydelige konsekvenser for pasienten og samfunnet. Fallforebyggende tiltak, som screeningverktøy, er utviklet for å identifisere pasienter med fallrisiko. Hensikten med studien var å sammenligne effekten av screeningverktøyene Downton Fall Risk Index (Downton) og Pasientsikkerhetsprogrammets ...

    • Prisforhandling for nye legemidler i spesialisthelsetjenesten Er det sammenheng mellom fremforhandlet rabatt og prisforhandlingstid? 

      Rafiq, Sania (Mastergradsoppgave; Master thesis, 2022-05-16)
      Bakgrunn: Kostnadseffektive legemidler er en forutsetning for offentlig finansiering av nye legemidler til bruk i spesialisthelsetjenesten i Norge. Prisforhandling med leverandørselskapene utføres av Sykehusinnkjøp HF på vegne av de regionale helseforetakene. I en prisforhandling tilbyr leverandørene en konfidensiell tilbudspris, og dersom den ikke regnes som kostnadseffektiv kan det resultere i at ...

    • Hvor stor andel av diabetespasienter i Tromsø7 når behandlingsmålet for HbA1c? 

      Bayram, Kübra (Mastergradsoppgave; Master thesis, 2023-05-15)
      Bakgrunn: Over de siste har det vært en betydelig økning i insidens og prevalens av diabetes mellitus (DM). Dersom sykdommen er dårlig kontrollert kan det over tid føre til utvikling og/eller forverring av andre sykdommer og i verste fall til død. En god blodsukkerkontroll hos diabetespasienter er derfor veldig viktig for å hindre slike hendelser. Dette kan oppnås gjennom å bruke blodsukkersenkende ...

    • Molecular modeling of the monoamine transporters and their interactions with psychostimulants and other substances 

      Gashi, Ejona (Mastergradsoppgave; Master thesis, 2023-05-15)
      The monoamines (i.e., dopamine, serotonin, and norepinephrine) are vital to the ontogeny, function, and plasticity of the nervous system. These neurotransmitters affect each other and regulate, amongst others, motor function, cognitive state, motivation, and stress reactions. The neurotransmission is mainly terminated by reuptake in monoamine transporters (MATs), i.e., the dopamine-, serotonin-, and ...

    • Synthesis, bioactivity testing, and structure elucidation of antimicrobial peptide analogues derived from Synoicum Turgens 

      Kristensen, Johannes (Mastergradsoppgave; Master thesis, 2023-05-15)
      A method was developed for synthesizing and isolating two DRPs, with varying levels of success affected by difficulties in the purification process and human error. However, it has shed light on some of the difficulties that may occur and suggestions on how they could be improved. The method developed structure elucidation through sequential reduction and alkylation of the disulfide bridges proved ...

    • Mass Spectrometry Based Metabolomic and Lipidomic Analyses of Algal Biomass. 

      Antonsen, Magnus Andersland (Mastergradsoppgave; Master thesis, 2023-05-14)
      Background: In a project at UiT - the Arctic University of Norway, the lipid profile of the microalgal biomass from the specie Porosira glacialis is mapped using HRMS lipidomic analyses to evaluate the potential for the biomass to be used as fish feed. At the same time, it is desired to screen the same biomass for bioactivities using bioassays in combination with HRMS metabolomic analyses. ...

    • Isolation and characterization of secondary metabolites from Arctic, Marine Invertebrates 

      Nyborg, Amalie Rebekka (Mastergradsoppgave; Master thesis, 2022-05-11)
      The search for bioactive compounds, or genes in macro- and microorganisms from the sea, is termed marine bioprospecting. Marine bioprospecting aims to increase the utilization and value of marine biomasses and organisms with the purpose of developing commercial products. Because of the special condition of the sea, it is known that marine invertebrates have adapted chemical defense strategies to ...

    • Innvirkning av syklisk-di-GMP signalisering på antimikrobiell resistens i Acinetobacter baumannii. Undersøkelser av relativ genekspresjon og fenotypiske effekter hos transposon insersjonsmutanter i putative c-di-GMP signaliseringsgener. 

      Phung, Minh Chau Nguyen (Mastergradsoppgave; Master thesis, 2020-06-03)
      Antimikrobiell resistens (AMR) utgjør en av de tre viktigste helseproblemene i verden i dag, og kan medføre alvorlige konsekvenser ifølge Verdens helseorganisasjon (WHO). Resistensutviklingen fører til terapisvikt mot infeksjonssykdommer som tidligere lot seg behandle av antimikrobielle midler og flere millioner menneskeliv kan gå tapt, hvis ikke tiltak iverksettes for å redusere forekomsten av AMR. ...