dc.contributor.author | Sæther, Linn Sofie | |
dc.contributor.author | Ueland, Thor | |
dc.contributor.author | Haatveit, Beathe | |
dc.contributor.author | Maglanoc, Luigi | |
dc.contributor.author | Szabo, Attila | |
dc.contributor.author | Djurovic, Srdjan | |
dc.contributor.author | Aukrust, Pål | |
dc.contributor.author | Roelfs, Daniël | |
dc.contributor.author | Ormerod, Monica Bettina E. Greenwood | |
dc.contributor.author | Lagerberg, Trine Vik | |
dc.contributor.author | Steen, Nils Eiel | |
dc.contributor.author | Melle, Ingrid | |
dc.contributor.author | Andreassen, Ole | |
dc.contributor.author | Ueland, Torill | |
dc.contributor.author | Mohn, Christine | |
dc.date.accessioned | 2023-02-08T08:05:54Z | |
dc.date.available | 2023-02-08T08:05:54Z | |
dc.date.issued | 2022-12-28 | |
dc.description.abstract | A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in
severe mental illnesses (SMI), such as schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, multivariate relationships
between peripheral inflammatory/immune-related markers and cognitive domains are unclear, and many studies do not account for
inter-individual variance in both cognitive functioning and inflammatory/immune status. This study aimed to investigate covariance
patterns between inflammatory/immune-related markers and cognitive domains and further elucidate heterogeneity in a large SMI and
healthy control (HC) cohort (SZ = 343, BD = 289, HC = 770). We applied canonical correlation analysis (CCA) to identify modes of
maximum covariation between a comprehensive selection of cognitive domains and inflammatory/immune markers. We found that
poor verbal learning and psychomotor processing speed was associated with higher levels of interleukin-18 system cytokines and beta
defensin 2, reflecting enhanced activation of innate immunity, a pattern augmented in SMI compared to HC. Applying hierarchical
clustering on covariance patterns identified by the CCA revealed a high cognition—low immune dysregulation subgroup with
predominantly HC (24% SZ, 45% BD, 74% HC) and a low cognition—high immune dysregulation subgroup predominantly consisting of
SMI patients (76% SZ, 55% BD, 26% HC). These subgroups differed in IQ, years of education, age, CRP, BMI (all groups), level of
functioning, symptoms and defined daily dose (DDD) of antipsychotics (SMI cohort). Our findings suggest a link between cognitive
impairment and innate immune dysregulation in a subset of individuals with severe mental illness. | en_US |
dc.identifier.citation | Sæther, Ueland, Haatveit, Maglanoc LA, Szabo, Djurovic, Aukrust, Roelfs, Ormerod, Lagerberg, Steen, Melle, Andreassen, Ueland. Inflammation and cognition in severe mental illness: patterns of covariation and subgroups. Molecular Psychiatry. 2022 | en_US |
dc.identifier.cristinID | FRIDAID 2100500 | |
dc.identifier.doi | 10.1038/s41380-022-01924-w | |
dc.identifier.issn | 1359-4184 | |
dc.identifier.issn | 1476-5578 | |
dc.identifier.uri | https://hdl.handle.net/10037/28509 | |
dc.language.iso | eng | en_US |
dc.publisher | Springer Nature | en_US |
dc.relation.journal | Molecular Psychiatry | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | Inflammation and cognition in severe mental illness: patterns of covariation and subgroups | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |