Now showing items 1041-1060 of 1850

    • Lifestyle factors including diet and biochemical biomarkers in acute intermittent porphyria: Results from a case-control study in northern Norway 

      Storjord, Elin; Dahl, Jim André; Landsem, Anne; Ludviksen, Judith K; Karlsen, Marlene; Karlsen, Bård Ove; Brekke, Ole-Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-10)
      <i>Background</i>: Lifestyle factors, including a low intake of carbohydrates, dieting, alcohol consumption, cigarette smoking and stress are some of the possible triggers of attacks in acute intermittent porphyria (AIP). The influence of lifestyle factors, including energy intake, diet and alcohol consumption on the biochemical disease activity in AIP and biochemical nutritional markers were ...
    • Psychological distance of climate change and mental health risks assessment of smallholder farmers in Northern Ghana: Is habituation a threat to climate change? 

      Acharibasam, Jeremiah Wezanamo; Anuga, Samuel Weniga (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-06)
      Although strong evidence shows climate change has physical impacts on human health, the mental health impacts appear unclear. The study aims to understand and explain the dynamic correlates between climate change and farmers’ emotional regulation practices, given psychological distance. Using 180 smallholder farmers in Northern Ghana, structural equation linear regression analysis showed that ...
    • Bruk av medikamenter for alkoholbrukslidelser i Norge 2004–16 

      Heldal, Anne Taraldsen; Skurtveit, Svetlana; Lobmaier, Philipp Paul K.; Vederhus, John-Kåre; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-08)
      <p><i>Bakgrunn - </i>Alkoholbrukslidelser forårsaker alvorlig sykelighet og tidlig død. Livstidsprevalens estimeres til 7–10 % i den norske befolkningen. Mange pasienter kommer ikke inn i behandlingsapparatet, og det antas at få av dem som kommer i behandling får medikamentell behandling. På markedet er det flere medikamenter som kan hjelpe til med å redusere mengde inntatt alkohol og å opprettholde ...
    • A novel combination of peripheral nerve blocks for arthroscopic shoulder surgery 

      Musso, Dario Davide; Flohr-Madsen, Sandra; Meknas, Khaled; Wilsgaard, Tom; Ytrebø, Lars Marius; Klaastad, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-04)
      <p><i>Background - </i>Interscalene brachial plexus block is currently the gold standard for intra‐ and post‐operative pain management for patients undergoing arthroscopic shoulder surgery. However, it is associated with block related complications, of which effect on the phrenic nerve have been of most interest. Side effects caused by general anesthesia, when this is required, are also a concern. ...
    • A randomised placebo-controlled trial examining the effect on hand supination after the addition of a suprascapular nerve block to infraclavicular brachial plexus blockade 

      Flohr-Madsen, Sandra; Ytrebø, Lars Marius; Valen, Katrin; Wilsgaard, Tom; Klaastad, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-11)
      Some surgeons believe that infraclavicular brachial plexus blocks tends to result in supination of the hand/forearm, which may make surgical access to the dorsum of the hand more difficult. We hypothesised that this supination may be reduced by the addition of a suprascapular nerve block. In a double‐blind, randomised, placebo‐controlled study, our primary outcome measure was the amount of supination ...
    • Minimum effective volume of ropivacaine 7.5mg/ml for an ultrasound-guided infraclavicular brachial plexus block 

      Flohr-Madsen, Sandra; Ytrebø, Lars Marius; Kregnes, Sylvia Beate; Wilsgaard, Tom; Klaastad, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-02-18)
      <p><i>Background - </i>Ultrasound guidance has been shown to reduce the minimum effective volume (MEV) of local anaesthetics for several peripheral nerve blocks. Although the lateral sagittal infraclavicular block (LSIB) is a well‐established anaesthesia method, MEV for this technique has not been established. Our aim with this study was to determine the MEV using ropivacaine 7.5 mg/ml for the LSIB ...
    • Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation 

      Skjeflo, Espen Waage; Christiansen, Dorte; Fure, Hilde; Ludviksen, Judith K; Woodruff, Trent M.; Espevik, Terje; Nielsen, Erik Waage; Brekke, Ole-Lars; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-13)
      <p><i>Background - </i>There is extensive cross‐talk between the complement system, the Toll‐like receptors (TLRs), and hemostasis. Consumptive coagulopathy is a hallmark of sepsis, and is often mediated through increased tissue factor (TF) expression. <p><i>Objectives - </i>To study the relative roles of complement, TLRs and TF in <i>Staphylococcus aureus</i>‐induced coagulation. <p><i>Methods - ...
    • Growing up with parental substance use disorder: The struggle with complex emotions, regulation of contact, and lack of professional support 

      Wangensteen, Turid; Bramness, Jørgen Gustav; Halsa, Astrid Dagmar (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-20)
      The aim of the study was to explore young people's perceptions and reflections about growing up with parents who have substance use disorder (SUD). In qualitative inter-views with 12 young people (aged 13–26) and in an interpretative phenomenological analysis, we investigated their experiences of everyday life, of the relationships with the parents with SUD, and of conversations about this, both ...
    • Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-06)
      The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders with evidence of subtle neurodevelopmental, structural and functional neuronal abnormalities. We aimed to elucidate the role of aberrant regulation of the Wnt system in these disorders ...
    • Complications, reoperations, readmissions, and length of hospital stay in 34 639 surgical cases of lumbar disc herniation 

      Fjeld, Olaf Randall; Grøvle, Lars; Helgeland, Jon; Småstuen, Milada Cvancarova; Solberg, Tore; Zwart, John-Anker; Grotle, Margreth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-01)
      <i>Aims</i>: The aims of this study were to determine the rates of surgical complications, reoperations, and readmissions following herniated lumbar disc surgery, and to investigate the impact of sociodemographic factors and comorbidity on the rate of such unfavourable events.<p> <p><i>Patients and Methods</i>: This was a longitudinal observation study. Data from herniated lumbar disc ...
    • DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia 

      Borssén, Magnus; Nordlund, Jessica; Haider, Zahra; Landfors, Mattias; Larsson, Pär; Kanerva, Jukka; Schmiegelow, Kjeld; Flægstad, Trond; Jónsson, Ólafur Gísli; Frost, Britt-Marie; Palle, Josefine; Forestier, Erik; Heyman, Mats; Hultdin, Magnus; Lönnerholm, Gudmar; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-05)
      <p><i>Background</i>: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL ...
    • Circulating delta-like Notch ligand 1 is correlated with cardiac allograft vasculopathy and suppressed in heart transplant recipients on everolimus-based immunosuppression 

      Norum, Hilde Margrethe; Michelsen, Annika; Lekva, Tove; Arora, Satish; Otterdal, Kari; Olsen, Maria Belland; Kong, Xiang Yi; Gude, Einar; Andreassen, Arne K.; Solbu, Dag; Karason, Kristjan; Dellgren, Göran; Gullestad, Lars; Aukrust, Pål; Ueland, Thor (Journal article; Tidsskriftartikkel, 2018-10-12)
      Cardiac allograft vasculopathy (CAV) causes heart failure after heart transplantation (HTx), but its pathogenesis is incompletely understood. Notch signaling, possibly modulated by everolimus (EVR), is essential for processes involved in CAV. We hypothesized that circulating Notch ligands would be dysregulated after HTx. We studied circulating delta‐like Notch ligand 1 (DLL1) and periostin (POSTN) ...
    • Stroke identification by criteria based dispatch - a register based study 

      Ellensen, Eirin Nybø; Næss, Halvor; Wisborg, Torben; Hunskaar, Steinar; Zakariassen, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-05)
      <i>Background</i>: Rapid and precise dispatch of resources is a key element in pre‐hospital emergency medicine. Emergency medical communication centres (EMCCs) dispatch resources based on protocols and guidelines, balancing the acute need of the individual and the resource allocation of the pre‐hospital emergency medical system. The aim of this study was to determine the validity of stroke ...
    • Tobacco smoking and cessation and PDL1 inhibitors in non-small cell lung cancer (NSCLC): a review of the literature 

      Norum, Jan; Nieder, Carsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-02)
      <p><i>Background</i>: Programmed death ligand 1 (PD-L1) targeting immunotherapies, as pembrolizumab and nivolumab, have significantly improved outcome in patients with non-small cell lung cancer (NSCLC). Tobacco smoking is the number one risk factor for lung cancer and is linked to 80%–90% of these cancers. Smoking during cancer therapy may influence on radiotherapy and chemotherapy outcome. We aimed ...
    • Ultrasound-guided Sympathetic Block of the Radial Artery with Botulinum Toxin to Treat Vasospasm 

      Weum, Sven; de Weerd, Louis (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-12)
      Summary: Vasospastic disorders in the hand have been treated with surgical sympathectomy and recently with botulinum toxin A (BTX) injections in the palm. The purpose of this study was to evaluate if it is possible to obtain precise administration of BTX around the radial artery using a single ultrasound-guided injection. We present a novel technique using 1 single ultrasound-guided BTX injection ...
    • Low levels of immunoglobulins and mannose-binding lectin are not associated with etiology, severity, or outcome in community-acquired pneumonia 

      Siljan, William Ward; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Skattum, Lillemor; Bosnes, Vidar; Garred, Peter; Frøland, Stig Sophus; Mollnes, Tom Eirik; Aukrust, Pål; Heggelund, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-05)
      <p><i>Background - </i>Disease severity and outcome in community-acquired pneumonia (CAP) depend on the host and on the challenge of the causal microorganism(s). We measured levels of immunoglobulins (Igs) and complement in 257 hospitalized adults with CAP and examined the association of low levels of Igs or complement to microbial etiology, disease severity, and short-term and long-term ...
    • Effect of requiring a general practitioner at scenes of serious injury: A systematic review 

      Straumann, Gyri Synnøve Hval; Austvoll-Dahlgren, Astrid; Holte, Hilde H; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-05)
      <p><i>Background - </i>In Norway, each municipality is responsible for providing first line emergency healthcare, and it is mandatory to have a primary care physician/general practitioner on call continuously. This mandate ensures that a physician can assist patients and ambulance personnel at the site of severe injuries or illnesses. The compulsory presence of the general practitioner at the scene ...
    • PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress 

      Toft, Helge Prytz; Bramness, Jørgen Gustav; Lien, Lars; Abebe, Dawit Shawel; Wampold, Bruce E.; Tilden, Terje; Hestad, Knut; Neupane, Sudan Prasad (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-17)
      <p><i>Background</i>: A reciprocal relationship between activated innate immune system and changes in mood and behavior has been established. There is still a paucity of knowledge on how the immune system responds during psychiatric treatment. We aimed to explore circulating cytokines and assess psychiatric symptom severity scores during 12 weeks of inpatient psychiatric treatment.</p> <p><i>Methods</i>: ...
    • Acceptability of an mHealth app intervention for persons with type 2 diabetes and its associations with initial self-management: Randomized controlled trial 

      Torbjørnsen, Astrid; Småstuen, Milada Cvancarova; Jenum, Anne Karen; Årsand, Eirik; Ribu, Lis (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-21)
      <p><i>Background</i>: Mobile health interventions are increasingly used in health care. The level of acceptability may indicate whether and how such digital solutions will be used.</p> <p><i>Objective</i>: This study aimed to explore associations between the level of acceptability of a mobile diabetes app and initial ability of self-management for patients with type 2 diabetes.</p> <p><i>Methods</i>: ...
    • Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study 

      Van Essen, Thomas; den Boogert, HF; Cnossen, MC; De Ruiter, Godard CW; Haitsma, Ian; Polinder, S; Steyerberg, Ewout W.; Menon, David; Maas, Andrew I. R.; Lingsma, Hester F; Peul, Wilco; Andelic, Nada; Helseth, Eirik; Roise, O; Røe, Cecilie; Vik, Anne; Skandsen, Toril; Anke, Audny; Frisvold, Shirin Kordasti (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-19)
      <p><i>Background</i>: Neurosurgical management of traumatic brain injury (TBI) is challenging, with only low-quality evidence. We aimed to explore differences in neurosurgical strategies for TBI across Europe.</p> <p><i>Methods</i>: A survey was sent to 68 centers participating in the Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. The ...