Institutt for klinisk medisin: Recent submissions

Now showing items 1121-1140 of 1850

    • Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction 

      Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne; Broch, Kaspar; Holte, Espen; Ryan, Liv; Amundsen, Brage H.; Bendz, Bjørn; Aakhus, Svend; Espevik, Terje; Halvorsen, Bente; Mollnes, Tom Eirik; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål; Damås, Jan Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-29)
      <p><i>Aim</i>: To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI).</p> <p><i>Methods</i>: 117 patients with acute NSTEMI were randomised to an intravenous infusion of 280 mg tocilizumab or placebo prior to coronary angiography. Blood samples were obtained at baseline, at 6 consecutive ...

    • Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study 

      Lappegård, Jostein; Ellingsen, Trygve; Hindberg, Kristian; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Løchen, Maja-Lisa; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-10)
      Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic inflammation as measured by high sensitivity CRP (hs-CRP) on this relationship, and explore whether RDW could be a mediator in the causal pathway between ...

    • Diabetes on Twitter: A Sentiment Analysis 

      Gabarron, Elia; Dorronzoro, Enrique; Rivera-Romero, Octavio; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-19)
      Background: <br>Contents published on social media have an impact on individuals and on their decision-making. Knowing the sentiment towards diabetes is fundamental to understanding the impact that such information could have on people affected with this health condition and their family members. The objective of this study is to analyze the sentiment expressed in messages on diabetes posted ...

    • Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism 

      Høiland, Ina Isabella; Liang, Robin Amanda; Hindberg, Kristian; Latysheva, Nadezhda; Brekke, Ole-Lars; Mollnes, Tom Eirik; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-30)
      INTRODUCTION: Deep vein thrombosis (DVT) originates in the valvular sinuses of large veins in a local milieu characterized by stasis and severe hypoxia. This may induce complement- and coagulation activation, which potentially increases the risk of venous thromboembolism (VTE). The aim of the present study was to investigate whether the activity of the complement pathways, the level of mannose-binding ...

    • The Service User Technology Acceptability Questionnaire: Psychometric Evaluation of the Norwegian Version 

      Torbjørnsen, Astrid; Småstuen, Milada C; Jenum, Anne Karen; Årsand, Eirik; Ribu, Lis (Journal article; Tidsskriftartikkel; Peer reviewed, 2018)
      <p><i>Background</i>: When developing a mobile health app, users’ perception of the technology should preferably be evaluated. However, few standardized and validated questionnaires measuring acceptability are available.</p> <p><i>Objective</i>: The aim of this study was to assess the validity of the Norwegian version of the Service User Technology Acceptability Questionnaire (SUTAQ).</p> <p ...

    • Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction 

      Orrem, Hilde Lang; Shetelig, Christian; Ueland, Thor; Limalanathan, Shanmuganathan; Nilsson, Per; Husebye, Trygve Guttorm; Aukrust, Pål; Seljeflot, Ingebjørg; Hoffmann, Pavel; Eritsland, Jan; Mollnes, Tom Eirik; Andersen, Geir Øystein; Yndestad, Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-28)
      <p><i>Background</i>: The inflammatory response following myocardial infarction (MI) is prerequisite for proper healing of infarcted tissue, but can also have detrimental effects on cardiac function. Interleukin (IL)-1α and IL-1β are potent inflammatory mediators and their bioactivity is tightly regulated by IL-1 receptor antagonist (IL-1ra) and soluble (s) IL-1 receptors (R). We aimed to examine ...

    • The Norwegian version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR) 

      Flatø, Berit; Rygg, Marite; Nordal, Ellen Berit; Røisland, Mona; Ødegård, Hanne Beate; Hoftun, Gry Børmark; Songstad, Nils Thomas; Consolaro, Alessandro; Bovis, Francesca; Ruperto, Nicolino (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-07)
      The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Norwegian language. The reading comprehension of ...

    • Short-term outcomes after elective colon cancer surgery: an observational study from the Norwegian registry for gastrointestinal and HPB surgery, NoRGast 

      Nymo, Linn Såve; Norderval, Stig; Eriksen, Morten Tandberg; Wasmuth, Hans; Kørner, Hartwig; Bjørnbeth, Bjørn Atle; Moger, Thomas; Viste, Asgaut; Lassen, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-09)
      BACKGROUND: To describe the real burden of major complications after elective surgery for colon cancer in Norway, and to assess which predictors that are significantly associated with the short-term outcome. <br> <br> METHODS: An observational, multi-centre analysis of prospectively registered colon resections registered into the Norwegian Registry for Gastrointestinal Surgery, NoRGast, between ...

    • Serum PCSK9 is modified by interleukin-6 receptor antagonism in patients with hypercholesterolaemia following non-ST-elevation myocardial infarction 

      Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Aukrust, Pål; Gullestad, Lars; Halvorsen, Bente; Yndestad, Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-18)
      <p><i>Objective</i>: It is unclear if activation of inflammatory pathways regulates proprotein convertase subtilisin-kexin type 9 (PCSK9) levels.</p> <p><i>Approach</i>: We evaluated (1) the temporal course of serum PCSK9 during hospitalisation following acute coronary syndrome and associations with markers of inflammation (leucocyte counts, interleukin (IL)-6, C-reactive protein) and lipid levels ...

    • Plasma hepcidin is associated with future risk of venous thromboembolism 

      Ellingsen, Trygve; Lappegård, Jostein; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018)
      Red cell distribution width (RDW) is associated with venous thromboembolism (VTE), but the underlying mechanism(s) is unclear. Iron deficiency is associated with high RDW, and studies suggest an association between iron deficiency and VTE. To assess whether iron deficiency is a risk factor for VTE that explains the association between RDW and VTE, we conducted a nested case-control study of 390 ...

    • The Palliative Radiotherapy and Inflammation Study (PRAIS) - Protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain 11 Medical and Health Sciences 1103 Clinical Sciences 

      Habberstad, Ragnhild H; Frøseth, Trude Camilla Salvesen; Aass, Nina Kathrine; Abramova, Tatiana Mikhailovna; Baas, Theo; Mørkeset, Siri Tessem; Caraceni, Augusto; Laird, Barry J; Boland, Jason W.; Rossi, Romina; Garcia-Alonso, Elena; Stensheim, Hanne; Loge, Jon Håvard; Hjermstad, Marianne Jensen; Bjerkeset, Ellen; Bye, Asta; Lund, Jo-Åsmund; Solheim, Tora Skeidsvoll; Vagnildhaug, Ola Magne; Brunelli, Cinzia; Damås, Jan Kristian; Mollnes, Tom Eirik; Kaasa, Stein; Klepstad, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-28)
      <i><p>Background</i>: Radiation therapy (RT) results in pain relief for about 6 of 10 patients with cancer induced bone pain (CIBP) caused by bone metastases. The high number of non-responders, the long median time from RT to pain response and the risk of adverse effects, makes it important to determine predictors of treatment response. Clinical features such as cancer type, performance status and ...

    • UNN-leger gir håp mot smertene 

      Weum, Sven; de Weerd, Louis; Andreassen, Skjalg (Journal article; Tidsskriftartikkel, 2018-11-30)
      <i>Ingress</i>: En ny behandlingsmetode med ultralydveiledet injeksjon av Botox har gitt gode resultater for UNN-pasienter med smerter i hender, rygg og mage.

    • Tidlig ultralyd i svangerskapsomsorgen 

      Lauvrak, Vigdis; Norderhaug, Inger Natvig; Hagen, Gunhild; Movik, Espen; Acharya, Ganesh; Forus, Anne; Hofmann, Bjørn; Johnsen, Synnøve Lian; Kaasen, Anne; Melve, Kari Klungsøyr; Markestad, Trond; Salvesen, Kjell Å; Staff, Annetine; Roksund, Gisle; Klemp, Marianne; Fure, Brynjar (Research report; Forskningsrapport, 2012)
      <p><i>Hovedbudskap</i>: Rutinemessig tidlig ultralydundersøkelse i svangerskapsuke 11 - 13 kan ha samme formål som dagens tilbud om ultralyd i svangerskapsuke 17 - 19. Fordi nakkeoppklaring vil bli observert i svangerskapsuke 11 - 13, vil tidlig ultralyd avdekke flere fostre med risiko for kromosomavvik.</p> <p>Helseeffekter</p> <ul><li>Vi fant ingen dokumentasjon for helsemessig gevinst av ...

    • Preferences and interests of diabetes social media users regarding a health promotion intervention 

      Gabarron, Elia; Dorronzoro, Enrique; Bradway, Meghan; Rivera-Romero, Octavio; Wynn, Rolf; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-23)
      <p><i>Background</i>: Nowadays, rapid and accessible participatory research on diabetes can be carried out using social media platforms. The objective of this study was to identify preferences and interests of diabetic social media users regarding a health-promotion intervention targeting them.</p> <p><i>Methods</i>: Social media followers of the Norwegian Diabetes Association were invited to ...

    • A nutrition problem solved by a two-step endoscopic removal of a non-adjustable gastric band 

      Johansen, Christer; Norum, Jan; Engebretsen, Bernt E.; Agledahl, Uwe (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-01)
      Bariatric surgery is an effective approach for weight loss and short-term improvement in metabolic disorders. Stenosis is a common complication of gastric banding. Balloon dilatation or gastrotomy has been employed in this setting. Few studies have indicated endoscopic removal of the band a feasible procedure. We present a 60-year-old female who underwent gastric banding in 1985 and suffered from ...

    • Lindring av smerter hos kreftpasienter 

      Kongsgaard, Ulf; Kaasa, Stein; Dale, Ola; Ottesen, Stig; Nordøy, Tone; Hessling, Sten Erik; von Hofacker, Sebastian; Bruland, Øyvind; Lyngstadaas, Anita (Research report; Forskningsrapport, 2005)
      Denne rapporten er en bestilling fra tidligere Sosial-og helsedepartementet om å vurdere kunnskapsgrunnlaget om effekt av palliativ smertebehandling ved kreft, dvs. Effekt av ulike behandlingsmetoder for å lindre smerter hos pasienter med uhelbredelig (ikke-kurabel) kreftsykdom.

    • Immediate response in markers of inflammation and angiogenesis during exercise: a randomised cross-over study in heart transplant recipients 

      Yardley, Marianne; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Bjørkelund, Elisabeth; Gullestad, Lars; Nytrøen, Kari (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-28)
      <p><i>Background</i>: The present study explored and compared the immediate responses in markers of inflammation and angiogenesis in maintenance heart transplant (HTx) recipients before, during and after sessions of high-intensity interval training (HIT) versus moderate-intensity continuous training (MICT). The study aimed to explain some of the trigger mechanisms behind HIT in HTx recipients.</p> ...

    • Effekt av fysioterapi ved kneleddsartrose, begrenset til elektroterapi og øvelsesbehandling 

      Bjordal, Jan Magnus; Johansen, Oddmund; Holm, Inger; Zapffe, Knut; Nilsen, Ellen M; Kristiansen, Ivar Sønbø; Linnestad, Kristin Kamilla; Hofmann, Bjørn (Research report; Forskningsrapport, 2004)
      De viktigste symptomene ved kneleddsartrose er leddsmerter, nedsatt bevegelighet og muskelstyrke som etter hvert gir nedsatt funksjon og evne til å utføre dagliglivets aktiviteter. Mange av personene som rammes av kneleddsartrose er også overvektige som igjen kan føre til andre helseplager som kardiovaskulære lidelser og høyt blodtrykk. Fysioterapi, i form av øvelsesbehandling og elektroterapi, ...

    • Attenuated Notch signaling in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-23)
      The Notch signaling pathway plays a crucial role in neurodevelopment and in adult brain homeostasis. We aimed to further investigate Notch pathway activity in bipolar disorder (BD) and schizophrenia (SCZ) by conducting a pathway analysis. We measured plasma levels of Notch ligands (DLL1 and DLK1) using enzyme immunoassays in a large sample of patients (SCZ n = 551, BD n = 246) and healthy controls ...

    • Team talk and team decision processes: a qualitative discourse analytical approach to 10 real-life medical emergency team encounters 

      Gundrosen, Stine; Thomassen, Gøril; Wisborg, Torben; Aadahl, Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-03)
      <p><i>Objectives</i>: Explore the function of three specific modes of talk (discourse types) in decision-making processes.</p> <p><i>Design</i>: Ten real-life admissions of patients with critical illness were audio/video recorded and transcribed. Activity-type analysis (a qualitative discourse analytical method) was applied.</p> <p><i>Setting</i>: Interdisciplinary emergency teams admitting ...