Now showing items 1181-1200 of 1850

    • A randomized trial of telemedicine efficacy and safety for nonacute headaches 

      Müller, Kai Ivar; Alstadhaug, Karl Bjørnar; Bekkelund, Svein Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-11)
      <p><i>Objective</i>: To evaluate long-term treatment efficacy and safety of one-time telemedicine consultations for nonacute headaches.</p> <p><i>Methods</i>: We randomized, allocated, and consulted nonacute headache patients via telemedicine (n = 200) or in a traditional manner (n = 202) in a noninferiority trial. Efficacy endpoints, assessed by questionnaires at 3 and 12 months, included change ...
    • Criteria for failure and worsening after surgery for lumbar disc herniation: a multicenter observational study based on data from the Norwegian Registry for Spine Surgery 

      Werner, David Andreas Thomas; Grotle, Margreth; Gulati, Sasha; Austevoll, Ivar M.; Lønne, Greger; Nygaard, Øystein P.; Solberg, Tore K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-14)
      PURPOSE: In clinical decision-making, it is crucial to discuss the probability of adverse outcomes with the patient. A large proportion of the outcomes are difficult to classify as either failure or success. Consequently, cutoff values in patient-reported outcome measures (PROMs) for "failure" and "worsening" are likely to be different from those of "non-success". The aim of this study was to identify ...
    • Long-term dropout from school and work and mental health in young adults in Norway: A qualitative interview-based study 

      Ramsdal, Gro Hilde; Bergvik, Svein; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)
      School dropout is related to difficult life trajectories in Western society. Developing effective preventive interventions is urgent. Nevertheless, few studies have interviewed unemployed young adults in the aftermath of school dropout to understand their experiences with influential factors. We interviewed seven former students two to five years after they had dropped out and seven same-aged students ...
    • More histologic and ultrastructural degenerative signs in the subscapularis tendon and the joint capsule in male patients with shoulder impingement 

      Farfaras, Stefanos; Ejerhed, Lars Erik; Hallström, Erling; Hultenby, Kjell; Meknas, Khaled; Movin, Tomas; Papdogiannakis, Nikos; Kartus, Jüri Toomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-02)
      <p><i>Purpose</i>: The purpose of the present study was to analyze biopsy samples from the subscapularis tendon and from the joint capsule from male patients with shoulder impingement syndrome (SAIS) and compare them with samples from male patients with post-traumatic recurrent shoulder instability. The hypothesis of the study was that patients with SAIS would have more histologic and ultrastructural ...
    • Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement 

      Hauge, Karoline Kråkmo; Dahle, Gry; Bendz, Bjørn; Halvorsen, Per Steinar; Abdelnoor, Michael; Mollnes, Tom Eirik; Fosse, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-12)
      <i>Objectives</i>. The inflammatory response to on-pump cardiac surgery is well known. Systemic inflammatory response syndrome after transcatheter valve implantation (TAVI) has been reported. The objective of this study was to study the inflammatory response during TAVI, and compare with the response during surgical aortic valve replacement. <i>Methods</i>. Eighteen patients undergoing transcatheter ...
    • First-aid training in school: amount, content and hindrances 

      Bakke, Håkon Kvåle; Bakke, Harald Kvåle; Bjørlo Schwebs, Runa (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-17)
      <p><i>Background</i>: To increase knowledge and competence about first aid in the population, first‐aid instruction is included in primary and secondary school curricula. This study aimed to establish how much time is spent on first‐aid training, which first‐aid measures are taught, and which factors prevent teachers from providing the quantity and quality of first‐aid training that they wish to ...
    • CTLA-4 expression in the non-small cell lung cancer patient tumor microenvironment: diverging prognostic impact in primary tumors and lymph node metastases 

      Paulsen, Erna-Elise; Kilvær, Thomas Karsten; Rakaee, Mehrdad; Richardsen, Elin; Hald, Sigurd; Andersen, Sigve; Busund, Lill-Tove; Bremnes, Roy M.; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-13)
      The immune checkpoint receptor CTLA-4 plays a crucial part in negatively regulating T cell activation and maintaining self-tolerance. It is frequently overexpressed in a variety of malignancies, yet its prognostic impact in non-small cell lung cancer (NSCLC) remains unclear. We constructed tissue microarrays from tumor tissue samples and evaluated the immunohistochemical expression of CTLA-4 in 536 ...
    • Adverse events in hospitalised cancer patients: a comparison to a general hospital population 

      Haukland, Ellinor Christin; von Plessen, Christian; Nieder, Carsten; Vonen, Barthold (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-05)
      <p><i>Background</i>: Patients with cancer are often treated by many healthcare providers, receive complex and potentially toxic treatments that can increase the risk for iatrogenic harm. The aim of this study is to investigate whether hospitalised cancer patients are at higher risk of adverse events (AEs) compared to a general hospital population.</p> <p><i>Material and methods</i>: A total of ...
    • Does a parent-administrated early motor intervention influence general movements and movement character at 3 months of age in infants born preterm? 

      Fjørtoft, Toril Synnøve Larsson; Ustad, Tordis; Kaaresen, Per Ivar; Øberg, Gunn Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-30)
      <p><i>Background</i>: Studies of preterm and term-born infants have shown absent fidgety movements and an abnormal movement character to be related to brain lesions and unfavourable neurological outcomes.</p> <p><i>Aims</i>: The present study examines what effect a parent-administered early intervention program applied to preterm infants in a randomised control trial (RCT) between 34 and 36 ...
    • Are severely injured trauma victims in Norway offered advanced pre-hospital care? National, retrospective, observational cohort 

      Wisborg, Torben; Ellensen, Eirin Nybø; Svege, Ida Charlott; Dehli, Trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-26)
      <p><i>Background</i>: Studies of severely injured patients suggest that advanced pre‐hospital care and/or rapid transportation provides a survival benefit. This benefit depends on the disposition of resources to patients with the greatest need. Norway has 19 Emergency Helicopters (HEMS) staffed by anaesthesiologists on duty 24/7/365. National regulations describe indications for their use, and the ...
    • Performance of Norwegian civilian EMTs and army medics in penetrating trauma: a controlled simulation-based assessment 

      Blix, Sigurd Wisborg; Melau, Jørgen; Lund-Kordahl, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-25)
      <p><i>Background</i>: Penetrating trauma kills rapidly. Thorough and efficient examination and aggressive hemorrhage control is important to save lives. The aim of this study was to assess the skills of civilian Emergency Medical Technicians (EMTs) in bleeding examination and control compared to Army Medics. Our hypothesis was that civilian pre‐hospital systems perform at a lower level compared to ...
    • The Glasgow prognostic score: Useful information when prescribing palliative radiotherapy 

      Nieder, Carsten; Mannsåker, Bård; Dalhaug, Astrid; Pawinski, Adam; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-26)
      The purpose of the present retrospective study was to investigate whether a score reflecting systemic inflammatory processes [the Glasgow Prognostic Score (GPS)] provides relevant information for radiation oncologists. GPS is a three‑tiered score [0: normal C-reactive protein (CRP) and albumin; 1: one abnormal result; 2: increased CRP and low albumin]. Correlations between disease type and extent, ...
    • The effect of high-dose vitamin D3 supplementation on bone mineral density in subjects with prediabetes 

      Larsen, Anette Uhlving; Grimnes, Guri; Jorde, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-18)
      <p><i>Summary</i> The rationale of this study was to determine the effect of high-dose vitamin D3 supplementation on bone mineral density (BMD). Prediabetic males given vitamin D had significantly less reduction in BMD at the femoral neck compared to the controls. The clinical implications of our findings require further investigation.</p> <p><i>Introduction</i> Type 2 diabetes mellitus is ...
    • Local Control and overall survival after frameless radiosurgery: A single center experience 

      Bilger, Angelika; Frenzel, Florian; Oehlke, Oliver; Wiehle, Rolf; Milanovic, Dusan; Prokic, Vesna; Nieder, Carsten; Grosu, Anca-Ligia (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-06)
      <p><i>Introduction</i> Stereotactic radiosurgery (SRS) has been increasingly advocated for 1–3 small brain metastases. The goal of this study was to evaluate the clinical results in patients with brain metastases treated with LINAC-based SRS using a thermoplastic mask (non-invasive fixation system) and Image-Guided Radiotherapy (IGRT).</p> <p><i>Material and Methods</i> In this single-institution ...
    • A Three-Variable Model Predicts Short Survival in Patients With Newly Diagnosed Metastatic Renal Cell Carcinoma 

      Syed, Mohsan Ali; Nieder, Carsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-21)
      <p><i>Background</i> Patients with metastatic renal cell carcinoma (mRCC) have variable survival outcomes. When discussing management approaches and providing information to patients and caregivers, it is important to have realistic perspectives, especially if the expected prognosis is very unfavorable. In the present study, factors predicting this endpoint were analyzed.</p> <p><i>Methods</i> Data ...
    • Calculating the 30-day survival in acute myocardial infarction: should we use the treatment chain or the hospital catchment model? 

      Norum, Jan; Hansen, Tonya Moen; Hovland, Anders; Balteskard, Lise; Haug, Bjørn; Olsen, Frank; Trovik, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-12)
      <p><i>Introduction</i> Acute myocardial infarction (AMI) is a potentially deadly disease and significant efforts have been concentrated on improving hospital performance. A 30-day survival rate has become a key quality of care indicator. In Northern Norway, some patients undergoing AMI are directly transferred to the Regional Cardiac Intervention Center at the University Hospital of North Norway ...
    • Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia 

      Siljan, William Ward; Holter, Jan Cato; Nymo, Ståle Haugset; Husebye, Einar; Ueland, Thor; Aukrust, Pål; Mollnes, Tom Eirik; Heggelund, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-24)
      Background:<br> The inflammatory response to community-acquired pneumonia (CAP) is orchestrated through activation of cytokine networks and the complement system. We examined the association of multiple cytokines and the terminal complement complex (TCC) with microbial aetiology, disease severity and shortterm outcome.<br> Materials and methods: <br>Plasma levels of 27 cytokines and TCC were ...
    • Clenched fist sydrome: a case report 

      Nissen, Trygve; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-18)
      <p><i>Background - </i>The clenched fist syndrome/psycho-flexed hand, first described in the early 1980s, has not yet entered the major psychiatric textbooks. Curiously, the phenomenon has been illuminated mainly in journals and textbooks on hand surgery. There is a need to examine, describe, and understand this syndrome from a psychiatric perspective. <p><i>Case presentation - </i>We present a ...
    • Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses 

      Nilsson, Per; Thomas, Anub Mathew; Bergseth, Grete; Gustavsen, Alice; Volokhina, Elena B.; van den Heuvel, Lambertus P.; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-10)
      The complement system has obtained renewed clinical focus due to increasing number of patients treated with eculizumab, a monoclonal antibody inhibiting cleavage of C5 into C5a and C5b. The FDA approved indications are paroxysmal nocturnal haemoglobinuria and atypical haemolytic uremic syndrome, but many other diseases are candidates for complement inhibition. It has been postulated that eculizumab ...
    • Headache patients' satisfaction with telemedicine: a 12-month follow-up randomized non-inferiority trial 

      Müller, Kai Ivar; Alstadhaug, Karl Bjørnar; Bekkelund, Svein Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-21)
      Background and purpose: We investigated non-acute headache patients’ long-term satisfaction with a telemedicine consultation and consultation preferences in northern Norway. We hypothesized that patients were not less satisfied with telemedicine than traditional consultations. We also examined the influence of gender, age and education on satisfaction. <br> <br> Methods: For 2.5 years, patients ...