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norskInstitutt for klinisk medisin: Recent submissions
Now showing items 1-20 of 1850
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Patient-reported symptoms before adjuvant locoregional radiotherapy for breast cancer: triple-negative histology impacts the symptom burden
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-26)Background Multimodal breast cancer treatment may cause side effects reflected in patient-reported outcomes and/or symptom scores at the time of treatment planning for adjuvant radiotherapy. In our department, all patients have been assessed with the Edmonton Symptom Assessment System (ESAS; a questionnaire addressing 11 major symptoms and wellbeing on a numeric scale of 0–10) at the time of ... -
Effect of a low-carbohydrate diet on pain and quality of life in female patients with lipedema: a randomized controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-16)Objective: The primary objective of this study was to evaluate the effect of a low-carbohydrate diet (LCD) compared with a control diet on pain in female patients with lipedema. The secondary objectives were to compare the impact of the two diets on quality of life (QoL) and investigate potential associations of changes in pain with changes in body weight, body composition, and ketosis.<p> <p>Methods: ... -
Tumor versus Tumor Cell Targeting in Metal-Based Nanoparticles for Cancer Theranostics
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-10)The application of metal-based nanoparticles (mNPs) in cancer therapy and diagnostics (theranostics) has been a hot research topic since the early days of nanotechnology, becoming even more relevant in recent years. However, the clinical translation of this technology has been notably poor, with one of the main reasons being a lack of understanding of the disease and conceptual errors in the design ... -
Free Vascularized Fibula Graft as Primary Salvage Procedure for Acute Cervical Osteomyelitis Caused by Epidural Abscess
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-24)Acute cervical osteomyelitis due to an epidural abscess and pyogenic spondylodiscitis in an immunosuppressed patient with progressive myelopathy is a challenge for the reconstructive surgeon. This report presents our novel approach to treat such a condition in a 56-year-old patient in whom antibiotic treatment and decompression of the medulla by laminectomy of C4–C6 failed. Under general anesthesia, ... -
The prognostic importance of traumatic axonal injury on early MRI: the Trondheim TAI-MRI grading and quantitative models
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-19)Objectives We analysed magnetic resonance imaging (MRI) findings after traumatic brain injury (TBI) aiming to improve the grading of traumatic axonal injury (TAI) to better reflect the outcome.<p> <p>Methods Four-hundred sixty-three patients (8–70 years) with mild (n = 158), moderate (n = 129), or severe (n = 176) TBI and early MRI were prospectively included. TAI presence, numbers, and volumes ... -
Status epilepticus in POLG disease: a large multinational study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-01)We aimed to provide a detailed phenotypic description of status epilepticus (SE) in a large cohort of patients with POLG disease and identify prognostic biomarkers to improve the management of this life-threatening condition. In a multinational, retrospective study with data on patients with POLG disease from seven European countries, we identified those who had SE. The age of SE onset, accompanying ... -
Plugging of pipes by cohesive particles. Computed tomography investigation and theoretical analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-09)Flow regimes leading to clogging of pipes exist for most multiphase flows with cohesive particles. Although plugging is critical in many industrial and medical applications, there are few records describing the details of the process. To address the problem, we conduct a computed tomography (CT) study of plugging in a cohesive ice slurry. We run experiments for ice concentration of 15%, Re∼3500, ... -
Transdiagnostic Associations between Anger Hostility and Chemokine Interferon-gamma Inducible Protein 10
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-17)Objective: Many psychiatric disorders are linked to low grade systemic inflammation as measured by systemic cytokine levels. Exploration of cytokines and immune activity and their role in psychiatric symptoms may inform pathobiology and treatment opportunities. The aim of this study is to explore if there are associations between cytokines and psychiatric symptom clusters. Comparison between patients ... -
Botulinum Toxin A and B for Palmoplantar Hyperhidrosis
(Journal article; Tidsskriftartikkel, 2024-03-01)Introduction - Hyperhidrosis is characterized by unpredictable, uncontrollable and excessive sweating. It occurs at rest and is not related to temperature. Hyperhidrosis is a common disorder that has a negative impact on quality of life (QoL). The aim of this quality assurance study was to investigate how treatment of palmoplantar hyperhidrosis with botulinum toxin A (BTX-A) and botulinum toxin B ... -
Comparative Effectiveness and Persistence of SB4 and Reference Etanercept in Patients With Psoriatic Arthritis in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-10)Objective - We aim to compare drug effectiveness and persistence between the reference etanercept (ETN) and ETN biosimilar SB4 in patients with psoriatic arthritis (PsA) naive to ETN and to investigate drug effectiveness and persistence in those undergoing a mandatory nonmedical switch from ETN to SB4.<p> <p>Methods - We used a retrospective comparative database study including 1,138 patients ... -
The epidemiology of major depression among adults in Norway: an observational study on the concurrence between population surveys and registry data – a NCDNOR project
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-17)Background Mental health problems, and major depression in particular, are important public health issues. Following trends in the prevalence of major depression is difficult because of the costs and complications of diagnostic interviews and general population self-report health surveys. Scandinavian countries, however, have several central, population-based health registries. We aimed to ... -
Epidemiology and natural history of POLG disease in Norway: a nationwide cohort study
(Journal article; Tidsskriftartikkel, 2024-06-07)<p><i>Objective</i> To investigate the prevalence and natural history of POLG disease in the Norwegian population. <p><i>Methods</i> A national, population-based, retrospective study using demographic, clinical, and genetic data of patients with genetically confirmed POLG disease. The patients were diagnosed between 2002 and 2022, and were included into the Norwegian POLG Patient Registry. Patients ... -
Primary Retroperitoneal Lymph Node Dissection as Treatment for Low-volume Metastatic Seminoma in a Population-based Cohort: The Swedish Norwegian Testicular Cancer Group Experience
(Journal article; Tidsskriftartikkel, 2024-06-11)<p><i>Background and objective</i> There is an unmet need to avoid long-term morbidity associated with standard cytotoxic treatment for low-volume metastatic seminoma. Our aim was to assess the oncological efficacy and surgical safety of retroperitoneal lymph node dissection (RPLND) as treatment in a population-based cohort of metastatic seminoma patients with limited retroperitoneal lymphadenopat ... -
Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-13)Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most commonly selected measures or their potential sensitivity to detect changes resulting from the interventions being examined. The aim of this systematic review is to assess the ... -
Targeted temperature control following traumatic brain injury: ESICM/NACCS best practice consensus recommendations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-20)Aims and scope The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and require admission to the intensive care unit for intracranial pressure (ICP) management.<p> <p>Methods A group of 18 international neuro-intensive care experts in the acute ... -
Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-23)Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement of biomarkers features frequently. The aim of this systematic review was to assess the frequency and diversity of biomarker endpoints in cancer cachexia trials. A comprehensive ... -
Impact of Prosigna test on adjuvant treatment decision in lymph node-negative early breast cancer—a prospective national multicentre study (EMIT-1)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-04)Background: EMIT-1 is a national, observational, single-arm trial designed to assess the value of the Prosigna, Prediction Analysis of Microarray using the 50 gene classifier (PAM50)/Risk of Recurrence (ROR), test as a routine diagnostic tool, examining its impact on adjuvant treatment decisions, clinical outcomes, side-effects and cost-effectiveness. Here we present the impact on treatment ... -
Survival after docetaxel for metastatic castration-resistant prostate cancer in a rural health care setting
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-15)Introduction: The aim of this study was to evaluate overall survival of men who received systemic therapy with docetaxel for metastatic castrationresistant prostate cancer (MCRPC) in rural Nordland County, Norway. Prognostic factors related to treatment and other variables were evaluated.<p> <p>Material and methods: Overall, 132 pa tients were included in this retrospective study covering the ... -
Dietitians' experiences of nutrition assessment via TeleNutrition: “Video-calls are better than phone-calls, but it's probably difficult for patients to show their ankles on the screen”
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-27)Background & Aims: Nutrition assessment is integral to dietetic practice. TeleNutrition enabled dietitians to continue nutrition care provision during the COVID-19 pandemic but created challenges with undertaking nutrition assessment. The aim of the present study was to describe how dietitians in three Nordic countries perceived their nutrition assessment practice when physically distant from ... -
DNA methylation fine-tunes pro-and anti-inflammatory signalling pathways in inactive ulcerative colitis tissue biopsies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-21)DNA methylation has been implied to play a role in the immune dysfunction associated with inflammatory bowel disease (IBD) and the disease development of ulcerative colitis (UC). Changes of the DNA methylation and correlated gene expression in patient samples with inactive UC might reveal possible regulatory features important for further treatment options for UC. Targeted bisulfite sequencing ...
