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norskInstitutt for klinisk medisin: Recent submissions
Now showing items 1361-1380 of 1850
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Reporting Helicopter Emergency Medical Services in major incidents: A Delphi study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11)Objective:<br> Research on helicopter emergency medical services (HEMS) in major incidents is predominately based on case descriptions reported in a heterogeneous fashion. Uniform data reported with a consensus-based template could facilitate the collection, analysis, and exchange of experiences. This type of database presently exists for major incident reporting at www.majorincidentreporting.net. ... -
Joint effects of cancer and variants in the factor 5 gene on the risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09)Venous thromboembolism occurs frequently in cancer patients. Two variants in the factor 5 gene (F5), rs6025 encoding for the factor V Leiden mutation R506Q, and rs4524 encoding K858R, have been found to be associated with venous thromboembolism. We assessed the joint effect of active cancer and these two F5 variants on venous thromboembolism risk in a case-cohort study. Cases with a first venous ... -
Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: A Prospective Pilot Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-28)Introduction: Coagulation and fibrinolysis remain sparsely addressed with regards to acute respiratory distress syndrome (ARDS). We hypothesized that ARDS development might be associated with changes in plasma coagulation and fibrinolysis. Our aim was to investigate the relationships between ARDS diagnosis and plasma concentrations of tissue factor (TF), tissue plasminogen activator (t-PA), and ... -
Effects of Constant Flow vs. Constant Pressure Perfusion on Fluid Filtration in Severe Hypothermic Isolated Blood-Perfused Rat Lungs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-23)Victims of severe accidental hypothermia are prone to fluid extravasation but rarely develop lung edema. We hypothesize that combined hypothermia-induced increase in pulmonary vascular resistance (PVR) and a concomitant fall in cardiac output protect the lungs against edema development. Our aim was to explore in hypothermic- isolated blood-perfused rat lungs whether perfusion at constant ... -
Seasonal changes in vitamin D-effective UVB availability in Europe and associations with population serum 25-hydroxyvitamin D
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-30)Low vitamin D status is common in Europe. The major source of vitamin D in humans is ultraviolet B (UVB)-induced dermal synthesis of cholecalciferol, whereas food sources are believed to play a lesser role. Our objectives were to assess UVB availability (Jm−2) across several European locations ranging from 35° N to 69° N, and compare these UVB data with representative population serum 25-hydroxyvitamin ... -
Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-09)Background:<br>One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the agestandardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults ... -
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-15)Background:<br>Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defi ned as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher.<br> Methods:<br>For ... -
Usher syndrome in Denmark: mutation Spectrum and some clinical observations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-12)Background:<br> Usher syndrome (USH) is a genetically heterogeneous deafness-blindness syndrome, divided into three clinical subtypes: USH1, USH2 and USH3.<br> Methods:<br> Mutations in 21 out of 26 investigated Danish unrelated individuals with USH were identified, using a combination of molecular diagnostic methods.<br> Results:<br> Before Next Generation Sequencing (NGS) became available ... -
Rituximab-induced hypogammaglobulinemia and intravenous immunoglobulin replacement therapy do not protect against relapse in granulomatous with polyangiitis
(Journal article; Tidsskriftartikkel, 2016-08-10) -
D-Dimer Measured At First Venous Thromboembolism Is Associated With Future Risk Of Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12)D-dimer >5000 ng/ml at incident VTE is associated with a higher risk of subsequent cancer within one and two years. High D-dimer levels are also associated with more aggressive tumor biology and poor prognosis in these patients. As D-dimer is routinely measured in the assessment of suspected VTE, it may be a useful surrogate marker for the presence of an underlying malignancy. Our findings may suggest ... -
Multisite musculoskeletal pain in adolescence and later mental health disorders: a population-based registry study of Norwegian youth: the NAAHS cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-01)<b>Objectives:</b> To examine the association between multisite musculoskeletal pain in adolescence and mental health disorders in young adulthood. <br><b>Design and setting: </b>Data were obtained from a linkage between the Norwegian Patient Registry (2008 – 2012) and the Norwegian Arctic Adolescent Health Study, a school-based survey conducted among 10th grade students in North Norway (2003 – ... -
The relationship between pain and perceived stress in a population-based sample of adolescents – Is the relationship gender specific?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-01)In the current issue of the Scandinavian Journal of Pain, Berit Østerås, Hermundur Sigmundsson and Monika Haga investigates for potential gender differences in the relationship between pain and perceived stress in adolescents, and present interesting findings [1]. Females, both adolescent and adults, report more pain, psychosocial problems and mental health problems than males. On that note some ... -
The impact of partial hepatectomy on oxidative state in the liver remnant - An in vivo swine model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-24)Background Previous studies on oxidative state after partial hepatectomy (PHx) report conflicting data on levels of glutathione (GSH) and are mainly presented in rodent models by methodology less sensitive than the present technologies. The current swine model presents GSH levels and the following genetic response post-PHx, utilizing an analytical platform more sensitive and precise than earlier ... -
Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF
(Journal article; Tidsskriftartikkel, 2014-07-05)Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture. Inflammation has also become a central focus in atheroma development and endothelial cell activation is recognized as necessary for the recruitment of inflammatory cells to the ... -
CHRONIC NASAL CARRIAGE OF STAPHYLOCOCCUS AUREUS DOES NOT INCREASE THE RISK OF RELAPSE AND SEVERE INFECTIONS IN GRANULOMATOSIS WITH POLYANGIITIS PATIENTS WHEN RECEIVING RITUXIMAB MAINTENANCE TREATMENT
(Conference object; Konferansebidrag, 2014-06-10) -
Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer – a multicenter (in situ hybridization) study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-08)There is a need for better prognostication in prostate cancer (PC). “The micromanager of hypoxia”, microRNA-210 (miR-210) is directly linked to hypoxia, is overexpressed in PC and has been implied in tumor cell-fibroblast crosstalk. We investigated the prognostic impact of miR-210 in tumor cells and fibroblasts in PC. Tumor and stromal samples from a multicenter PC cohort of 535 prostatectomy patients ... -
What are diabetes patients discussing on social media?
(Conference object; Konferansebidrag, 2016-11-15)Social media channels are being used more and more by people with diabetes for exchanging health information, experiences with their chronic condition, and asking and giving advice to their peers[1]. The objective of this study is to describe the nature of the information that is shared on Norwegian diabetes social media groups, and the users’ reactions to these posts. -
Evaluation of a trauma team activation protocol revision: A prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-25)<b>Background:</b> Correct triage based on prehospital information contributes to a better outcome for potentially seriously injured patients. In 2011 we changed the trauma team activation (TTA) criteria in our center in order to improve the high over- and undertriage properties of the protocol. Five criteria that were unable to predict severe injury were removed. In the present study, we evaluated ... -
Weight Change and Risk of Venous Thromboembolism: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-20)<b>Background:</b> Obesity is a major risk factor for venous thromboembolism (VTE), but it is unknown to what extent weight change over time affects VTE risk.<br> <b>Aims:</b> To investigate the association between weight change and risk of incident VTE in a population-based cohort with repeated measurements.<br> <b>Methods:</b> Participant data were collected from the Tromsø 3 (1986–87), 4 ... -
Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)<i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using time-fixed analyses without and with correction for regression dilution and time-varying analyses.<p> <p><i>Methods:</i> ...
