Institutt for klinisk medisin: Recent submissions

Now showing items 41-60 of 1907

    • Health-Related Quality of Life in FKRP-Related Limb-Girdle Muscular Dystrophy R9 

      Jensen, Synnøve M; Friborg, Oddgeir; Mellgren, Svein Ivar; Müller, Kai Ivar; Bergvik, Svein Hugo; Arntzen, Kjell Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-02)
      Background: Limb-girdle muscular dystrophy R9 (LGMDR9) is a chronic progressive hereditary muscle disease, related to the Fukutin Related Protein (FKRP) gene, that may cause major disabilities, cardiomyopathy, and ventilatory failure. Knowledge of how LGMDR9 affects health-related quality of life (HRQoL) is relevant in treatment and care.<p> <p>Objective: To investigate HRQoL in the Norwegian ...

    • Functional outcome and associations with prehospital time and urban-remote disparities in trauma: A Norwegian national population-based study 

      Nilsbakken, Inger Marie Waal; Wisborg, Torben; Sollid, Stephen J. M.; Jeppesen, Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-05)
      Background - There is a lack of knowledge regarding the functional outcomes of patients after trauma. Remote areas in Norway has been associated with an increased risk of trauma-related mortality. However, it is unknown how this might influence trauma-related morbidity. The aim of this study was to assess the functional outcomes of patients in the Norwegian trauma population and the relationship ...

    • Initial surveillance in men with marker negative clinical stage IIA non-seminomatous germ cell tumours 

      Gerdtsson, Axel; Negaard, Helene Francisca Stigter; Almås, Bjarte; Bergdahl, Anna Grenabo; Cohn-Cedermark, Gabriella; Glimelius, Ingrid; Halvorsen, Dag; Haugnes, Hege Sagstuen; Hedlund, Annika; Hellström, Martin; Holmberg, Göran; Karlsdottir, Åsa; Kjellman, Anders; Larsen, Signe Melsen; Thor, Anna; Wahlqvist, Rolf; Ståhl, Olof; Tandstad, Torgrim (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-31)
      Objectives - To assess whether extended surveillance with repeated computed tomography (CT) scans for patients with clinical stage IIA (CS IIA; <2 cm abdominal node involvement) and negative markers (Mk−) non-seminomatous germ cell tumours (NSGCTs) can identify those with true CS I. To assess the rate of benign lymph nodes, teratoma, and viable cancer in retroperitoneal lymph node dissection (RPLND) ...

    • Escalated complement activation during hospitalization is associated with higher risk of 60-day mortality in SARS-CoV-2-infected patients 

      Barratt-Due, Andreas; Pettersen, Kristin; Dahl, Tuva Børresdatter; Holter, Jan Cato; Grønli, Renathe Henriksen; Dyrhol-Riise, Anne Ma; Lerum, Tøri Vigeland; Holten, Aleksander Rygh; Tonby, Kristian; Trøseid, Marius; Skjønsberg, Ole Henning; Granerud, Beathe Kiland; Heggelund, Lars; Kildal, Anders Benjamin; Schjalm, Camilla; Aaløkken, Trond Mogens; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Halvorsen, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-27)
      Background. The complement system, an upstream recognition system of innate immunity, is activated upon SARS-CoV-2 infection. To gain a deeper understanding of the extent and duration of this activation, we investigated complement activation profiles during the acute phase of COVID-19, its persistence post-recovery and dynamic changes in relation to disease severity.<p> <p>Methods. Serial ...

    • Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants 

      Glaser, Kirsten; Härtel, Christoph; Klingenberg, Claus Andreas; Herting, Egbert; Fortmann, Mats I.; Speer, Christian P.; Stensvold, Hans Jørgen; Huncikova, Zuzana; Rønnestad, Arild Erland; Nentwich, Martin M.; Stahl, Andreas; Dammann, Olaf; Göpel, Wolfgang (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-25)
      Importance - Retinopathy of prematurity (ROP) is a major morbidity of preterm infants causing visual impairment, including blindness, for which timely treatment is vital and prevention is key. Increasing evidence suggests that exposure to neonatal sepsis contributes to ROP development.<p> <p>Objective - To investigate the association between neonatal sepsis and ROP in 2 large-scale cohorts of ...

    • One-stage implant in sacral neuromodulation for faecal incontinence – short-term outcome from a prospective study 

      Duelund-Jakobsen, Jakob; Buntzen, Steen; Lundby, Lilli; Laurberg, Søren; Sørensen, Michael; Rydningen, Mona Birgitte (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-11)
      Aim: Sacral neuromodulation (SNM) is approved for the treatment of faecal incontinence (FI) in a two-stage technique. With standardized implantation, approximately 90% of pa tients undergo successful Stage I operation and proceed to a permanent implant (Stage II). The aim of this work was to explore the feasibility of SNM as a one-stage procedure and report the 24-week efficacy.<p> <p>Method: ...

    • Upper gastrointestinal endoscopy in the surgically altered patient 

      Bhat, Purnima; Kaffes, Arthur John; Lassen, Kristoffer; Aabakken, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-01)
      As management of upper gastrointestinal malignancies improves, and with popularization of bariatric surgery, endoscopists are likely to meet patients with altered upper gastrointestinal anatomy. Short-term, the surgery can cause complications like bleeding, leaks, and fistulas, and longer-term problems such as intestinal or biliary anastomotic strictures or biliary stones can arise, all ...

    • PALLiative care in ONcology (PALLiON): A cluster-randomised trial investigating the effect of palliative care on the use of anticancer treatment at the end of life 

      Hjermstad, Marianne Jensen; Pirnat, Aleksandra; Aass, Nina Kathrine; Andersen, Sigve; Astrup, Guro Lindviksmoen; Dajani, Olav; Garresori, Herish; Guldhav, Kristin Vassbotn; Hamre, Hanne Mari; Haukland, Ellinor Christin; Jordal, Frode; Lundeby, Tonje; Løhre, Erik Torbjørn; Mjåland, Svein; Paulsen, Ørnulf; Semb, Karin; Staff, Erik Schistad; Wester, Torunn Elin; Kaasa, Stein (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-09)
      Background: Effects on anticancer therapy following the integration of palliative care and oncology are rarely investigated. Thus, its potential effect is unknown.<p> <p>Aim: To investigate the effects of the complex intervention PALLiON versus usual care on end-of-life anticancer therapy.<p> <p>Design: Cluster-randomised controlled trial (RCT), registered at ClinicalTrials.gov (No. NCT01362816). ...

    • Stable glioma incidence and increased patient survival over the past two decades in Norway: a nationwide registry-based cohort study 

      Skaga, Erlend; Trewin-Nybråten, Cassia Bree; Niehusmann, Pitt; Johannessen, Tom Børge; Marienhagen, Kirsten; Oltedal, Leif; Schipmann, Stephanie; Skjulsvik, Anne Jarstein; Solheim, Ole Skeidsvoll; Solheim, Tora S; Sundstrøm, Terje; Vik-Mo, Einar Osland; Brandal, Petter; Ingebrigtsen, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-19)
      Background: Surveillance of incidence and survival of central nervous system tumors is essential to monitor disease burden and epidemiological changes, and to allocate health care resources. Here, we describe glioma incidence and survival trends by histopathology group, age, and sex in the Norwegian population.<p> <p>Material and methods: We included patients with a histologically verified glioma ...

    • Excess weight, weight gain, and prostate cancer risk and prognosis: the PROCA-life study 

      Støyten, Martin; Knutsen, Tore; Stikbakke, Einar; Agledahl, Ingvild; Wilsgaard, Tom; Eggen, Anne Elise; Richardsen, Elin Helmine; Giovannucci, Edward; Thune, Inger; Haugnes, Hege Sagstuen (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-09)
      Background: Studies of excess weight and weight changes throughout adult life for prostate cancer (PCa) risk and prognosis have shown inconsistent results.<p> <p>Methods: In a population-based cohort, the Prostate Cancer Study throughout life (PROCA-life), 16,960 healthy men from the prospective cohort Tromsø Study (1994–2016) were included. Body mass index (BMI) and weight were measured at all ...

    • Male patients with inflammatory joint diseases are less likely than controls to be childless: Results from a Norwegian population-based cohort study of 10 865 patients 

      Sigmo, Gudrun David; Hauge, Solveig; Hufthammer, Karl Ove; Wallenius, Marianne; Salvesen, Kjell Åsmund Blix; Daltveit, Anne Kjersti Nesje; Bakland, Gunnstein; Fevang, Bjørg Tilde Svanes (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-12)
      Objectives To investigate the number of children per man and the proportion of childless men as a proxy of fertility in a national cohort of men with inflammatory joint diseases (IJDs), compared with matched controls from the general population.<p> <p>Methods This is a nationwide, population-based retrospective cohort study. Male patients with IJDs (n = 10 865) in the Norwegian Arthritis ...

    • Histomolecular Validation of [18F]-FACBC in Gliomas Using Image-Localized Biopsies 

      Vindstad, Benedikte Emilie; Skjulsvik, Anne Jarstein; Pedersen, Lars Kjelsberg; Berntsen, Erik Magnus; Solheim, Ole Skeidsvoll; Ingebrigtsen, Tor; Reinertsen, Ingerid; Johansen, Håkon; Eikenes, Live; Karlberg, Anna Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-18)
      Background: Gliomas have a heterogeneous nature, and identifying the most aggressive parts of the tumor and defining tumor borders are important for histomolecular diagnosis, surgical resection, and radiation therapy planning. This study evaluated [<sup>18</sup>F]-FACBC PET for glioma tissue classification. Methods: Pre-surgical [<sup>18</sup>F]-FACBC PET/MR images were used during surgery ...

    • Lung cancer reirradiation: Exploring modifications to utilization, treatment modalities and factors associated with outcomes 

      Gullhaug, Anna; Haakensen, Vilde Drageset; De Ruysscher, Dirk; Simone, Charles B.; Hotca-Cho, Alexandra E.; Chhabra, Arpit M.; Hellebust, Taran Annette Paulsen; Paulsen, Erna-Elise; Dimopoulos, Maria P.; Johansen, Safora (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-29)
      Background: Patients treated for lung cancer (LC) often experience locoregional failure after initial treatment. Due to technological advances, thoracic reirradiation (re-RT) has become a viable treatment option. We sought to investigate the use of thoracic re-RT in LC patients over a time period characterized by technological advances in a large, multi-center cohort.<p> <p>Methods and materials: ...

    • Umbilical Cord pH Levels and Neonatal Morbidity and Mortality 

      Andersson, Charlotte Brix; Klingenberg, Claus Andreas; Thellesen, Line; Johnsen, Søren Paaske; Kesmodel, Ulrik Schiøler; Petersen, Jesper Padkaer (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-14)
      Importance Umbilical cord pH (UC-pH) level is an important objective indicator of intrapartum fetal hypoxia and is used to predict neonatal morbidity and mortality. A UC-pH value of less than 7.00 is often defined as a threshold for severe acidosis, but existing evidence is divergent and largely based on UC-pH measurements from selected populations; consequently, the results are challenging to ...

    • Extracellular vesicles from activated platelets possess a phospholipid-rich biomolecular profile and enhance prothrombinase activity 

      Mazagao Guerreiro, Eduarda; Kruglik, Sergei G.; Swamy, Samantha; Latysheva, Nadezhda; Østerud, Bjarne; Guigner, Jean-Michel; Sureau, Franck; Bonneau, Stephanie; Kuzmin, Andrey N.; Prasad, Paras N.; Hansen, John Bjarne; Hellesø, Olav Gaute; Snir, Omri (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-22)
      Background: Extracellular vesicles (EVs), in particular those derived from activated platelets, are associated with a risk of future venous thromboembolism. Objectives: To study the biomolecular profile and function characteristics of EVs from control (unstimulated) and activated platelets.<p> <p>Methods: Biomolecular profiling of single or very few (1-4) platelet-EVs (control/ stimulated) was ...

    • Performance of an Artificial Intelligence System for Breast Cancer Detection on Screening Mammograms from BreastScreen Norway 

      Larsen, Marthe; Olstad, Camilla Flåt; Lee, Christoph I.; Hovda, Tone; Hoff, Solveig Kristin Roth; Martiniussen, Marit Almenning; Mikalsen, Karl Øyvind; Lund-Hanssen, Håkon; Solli, Helene; Silberhorn, Marko; Sulheim, Åse Ø.; Auensen, Steinar Gøytil; Nygård, Jan Franz; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-10)
      A commercially available artificial intelligence system showed high performance in detecting breast cancers within 2 years of screening mammography and may help triage low-risk mammograms to reduce radiologist workload.<p> <p>Purpose - To explore the stand-alone breast cancer detection performance, at different risk score thresholds, of a commercially available artificial intelligence (AI) ...

    • Neutrophil Extracellular Traps in ST-Segment Elevation Myocardial Infarction: Reduced by Tocilizumab and Associated With Infarct Size 

      Kindberg, Kristine Mørk; Broch, Kaspar; Andersen, Geir Øystein; Anstensrud, Anne Kristine; Åkra, Sissel; Woxholt, Sindre; Tøllefsen, Ingvild Maria; Ueland, Thor; Amundsen, Brage H.; Kløw, Nils-Einar; Halvorsen, Bente; Dahl, Tuva Børresdatter; Huse, Camilla; Murphy, Sarah Louise Mikalsen; Damås, Jan Kristian; Opdahl, Anders; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål; Santos-Gallego, Carlos; Seljeflot, Ingebjørg; Stokke, Mathis Korseberg; Helseth, Ragnhild Merckoll (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-15)
      Background - Interleukin-6-receptor inhibition with tocilizumab improves myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI). Reduced levels of neutrophil extracellular traps (NETs), which consist of nuclear material studded with proteins released upon neutrophil activation, might contribute to this effect.<p> <p>Objectives - The purpose of this study was to ...

    • Patient-reported symptoms before adjuvant locoregional radiotherapy for breast cancer: triple-negative histology impacts the symptom burden 

      Nieder, Carsten; Johnsen, Silje Kristine; Winther, Annette M.; Mannsåker, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-26)
      Background Multimodal breast cancer treatment may cause side effects reflected in patient-reported outcomes and/or symptom scores at the time of treatment planning for adjuvant radiotherapy. In our department, all patients have been assessed with the Edmonton Symptom Assessment System (ESAS; a questionnaire addressing 11 major symptoms and wellbeing on a numeric scale of 0–10) at the time of ...

    • Effect of a low-carbohydrate diet on pain and quality of life in female patients with lipedema: a randomized controlled trial 

      Lundanes, Julianne; Sandnes, Frida Huhta; Gjeilo, Kari Hanne; Salater, Sissel; Alho Letra Martins, Catia Patricia; Nymo, Siren; Hanson, Patrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-16)
      Objective: The primary objective of this study was to evaluate the effect of a low-carbohydrate diet (LCD) compared with a control diet on pain in female patients with lipedema. The secondary objectives were to compare the impact of the two diets on quality of life (QoL) and investigate potential associations of changes in pain with changes in body weight, body composition, and ketosis.<p> <p>Methods: ...

    • Tumor versus Tumor Cell Targeting in Metal-Based Nanoparticles for Cancer Theranostics 

      Urbano-Gámez, Jesús David; Guzzi, Cinzia; Bernal, Manuel; Solivera, Juan; Martinez, Inigo Zubiavrre; Caro, Carlos; García-Martín, María Luisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-10)
      The application of metal-based nanoparticles (mNPs) in cancer therapy and diagnostics (theranostics) has been a hot research topic since the early days of nanotechnology, becoming even more relevant in recent years. However, the clinical translation of this technology has been notably poor, with one of the main reasons being a lack of understanding of the disease and conceptual errors in the design ...