Viser treff 1081-1100 av 1850

    • Comparative exoproteome profiling of an invasive and a commensal Staphylococcus haemolyticus isolate 

      Cavanagh, Jorunn Pauline; Pain, Maria Charlene Ronessen; Askarian, Fatemeh; Bruun, Jack-Ansgar; Urbarova, Ilona; Wai, Sun Nyunt; Schmidt, Frank; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-22)
      <p><i>Staphylococcus haemolyticus</i> is a skin commensal emerging as an opportunistic pathogen. Nosocomial isolates of <i>S. haemolyticus</i> are the most antibiotic resistant members of the coagulase negative staphylococci (CoNS), but information about other <i>S. haemolyticus</i> virulence factors is scarce. Bacterial membrane vesicles (MVs) are one mediator of virulence by enabling secretion and ...
    • Life after conflict-related amputation trauma: A clinical study from the Gaza Strip 

      Heszlein-Lossius, Hanne Edøy; Al-Borno, Yahya; Shaqqoura, Samar; Skaik, Nashwa; Melvær, Giil Lasse; Gilbert, Mads (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-31)
      <i>Background</i>: More than 17.000 Palestinians were injured during different Israeli military incursions on the Gaza Strip from 2006 to 2014. Many suffered traumatic extremity amputations. We describe the injuries, complications, living conditions and health among a selection of traumatic amputees in the Gaza Strip.<p> <p><i>Methods</i>: We included 254 civilian Palestinians who had survived, ...
    • Hypocomplementemia as a Risk Factor for Organ Damage Accrual in Patients with Systemic Lupus Erythematosus 

      Raymond, Warren David; Eilertsen, Gro Østli; Nossent, Johannes (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-30)
      While it is a common practice to monitor complement levels in patients with systemic lupus erythematosus to aid in flare prediction and detection, it is unclear if this strategy is helpful in preventing subsequent organ damage. We studied longitudinal complement levels in 102 SLE patients during a median follow-up of 13.8 years (IQR 7.0, 23.1). Low complement was defined as C3 < 0.84 g/L and/or ...
    • Factors Determining the Success and Failure of eHealth Interventions: Systematic Review of the Literature 

      Granja, Conceição; Janssen, Wouter; Johansen, Monika Alise (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-01)
      <p><i>Background</i>: eHealth has an enormous potential to improve healthcare cost, effectiveness, and quality of care. However, there seems to be a gap between the foreseen benefits of research and clinical reality.</p> <p><i>Objective</i>: Our objective was to systematically review the factors influencing the outcome of eHealth interventions in terms of success and failure.</p> <p><i>Methods</i>: ...
    • Local control and possibility of tailored salvage after hypofractionated stereotactic radiotherapy of the cavity after brain metastases resection 

      Bilger, Angelika; Bretzinger, Eva; Fennell, Jamina; Nieder, Carsten; Lorenz, Hannah; Oehlke, Oliver; Grosu, Anca-Ligia; Specht, Hanno M.; Combs, Stephanie E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-09)
      In patients undergoing surgical resection of brain metastases, the risk of local recurrence remains high. Adjuvant whole brain radiation therapy (WBRT) can reduce the risk of local relapse but fails to improve overall survival. At two tertiary care centers in Germany, a retrospective study was performed to evaluate the role of hypofractionated stereotactic radiotherapy (HFSRT) in patients with brain ...
    • Benchmarking of aggregated length of stay after open and laparoscopic surgery for cancers of the digestive system 

      Lassen, Kristoffer; Nymo, Linn Såve; Olsen, Frank; Søreide, Kjetil (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-23)
      <i>Background</i>: Length of hospital stay (LOS) may serve as a surrogate measure of healthcare quality and resource use, particularly when transfers of care and readmissions are accounted for. This study aimed to benchmark true hospital stay by measuring index, transfer and readmission stays across the range of digestive cancer surgery.<p> <p><i>Methods</i>: A cohort study of all patients ...
    • Culture-negative early-onset neonatal sepsis - at the crossroad between efficient sepsis care and antimicrobial stewardship 

      Klingenberg, Claus; Kornelisse, Rene F.; Buonocore, Giuseppe; Maier, Rolf F.; Stocker, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-09)
      Sepsis is a leading cause of mortality and morbidity in neonates. Presenting clinical symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of symptoms are suboptimal. Clinical suspicion therefore frequently leads to empirical antibiotic therapy in uninfected infants. The incidence of culture confirmed early-onset sepsis is rather low, around 0.4–0.8/1000 term ...
    • Sex differences in umbilical artery Doppler indices: A longitudinal study 

      Widnes, Christian; Flo, Kari; Wilsgaard, Tom; Kiserud, Torvid; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-18)
      <p><i>Background</i>: Sexual dimorphism in placental size and function has been described. Whether this influences the clinically important umbilical artery (UA) waveform remains controversial, although a few cross-sectional studies have shown sex differences in UA pulsatility index (PI). Therefore, we tested whether fetal sex influences the UA Doppler indices during the entire second half of pregnancy ...
    • Vitamin D supplementation does not improve CVD risk factors in vitamin D-insufficient subjects 

      Kubiak, Julia Magdalena; Thorsby, Per Medbøe; Kamycheva, Elena; Jorde, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06)
      <p><i>Objective</i>: Low serum 25(OH)D levels are associated with cardiovascular disease (CVD) and some of its risk factors. However, in interventional studies, the effects of vitamin D supplementation have been uncertain, possibly due to inclusion of vitamin D-sufficient subjects. Our aim was therefore to examine effects of vitamin D supplementation on CVD risk factors in vitamin D-insufficient ...
    • Clinical videoconferencing as ehealth: A critical-realist review and qualitative meta-synthesis 

      Ekeland, Anne G.; Hansen, Anne Helen; Bergmo, Trine Strand (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-25)
      <p><i>Background</i>: Earlier work has described videoconferencing technologies, peripheral equipment, organizational models, human relations, purposes, goals and roles as versatile, multifaceted, and those used differently in different clinical practices. Knowledge about benefits and challenges connected to specific characteristics of services are lacking. A 2005 systematic review of published ...
    • Health-related quality of life on tele-monitoring for users with pacemakers 6 months after implant: the NORDLAND study, a randomized trial 

      Lopez-Villegas, Antonio; Catalán-Matamoros, Daniel; Lopez-Liria, Remedios; Enebakk, Terje; Thunhaug, Hilde; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2018)
      <i>Background</i>: With an ageing population and widening indications for pacemakers implantation, the number of persons carrying an implant is steadily increasing. The routine follow-up is thus a heavy burden for the respective NHS as well as for the patients and their relatives. Most of them of the studies have been performed in densely populated areas and nearby to the hospital. It is thus ...
    • Large-scale secretome analyses unveil the superior immunosuppresive phenotype of umbilical cord stromal cells as compared to other adult mesenchymal stromal cells 

      Islam, Md Ashraful; Urbarova, Ilona; Bruun, Jack-Ansgar; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-20)
      Mesenchymal stromal cells (MSCs), given their regenerative potential, are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express several bioactive molecules which act in a paracrine fashion to modulate the tissue microenvironment. Yet, little is known about the divergence of these signalling molecules in different MSC populations. The present study investigated ...
    • Effects of Probiotic Supplementation on the Gut Microbiota and Antibiotic Resistome Development in Preterm Infants 

      Esaiassen, Eirin; Hjerde, Erik; Cavanagh, Jorunn Pauline; Pedersen, Tanja; Andresen, Jannicke Hanne; Rettedal, Siren; Støen, Ragnhild; Nakstad, Britt; Willassen, Nils Peder; Klingenberg, Claus (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-16)
      <i>Objectives</i>: In 2014 probiotic supplementation (<i>Lactobacillus acidophilus and Bifidobacterium longum subspecies infantis;</i> Infloran®) was introduced as standard of care to prevent necrotizing enterocolitis (NEC) in extremely preterm infants in Norway. We aimed to evaluate the influence of probiotics and antibiotic therapy on the developing gut microbiota and antibiotic resistome in ...
    • Population distribution of traditional and the emerging cardiovascular risk factors carotid plaque and IMT: The REFINE-Reykjavik study with comparison with the Tromsø study 

      Thorsson, Bolli; Eiríksdóttir, Gudny; Sigurdsson, Sigurdur; Gudmundsson, Elias Freyr; Bots, Michiel L.; Aspelund, Thor; Arntzen, Kjell Arne; Mathiesen, Ellisiv B.; Gudnason, Vilmundur (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-31)
      <p><i>Objectives</i>: Population statistics for carotid plaque and cardiovascular risk factors reported in scientific journals are usually presented as averages for the population or age and sex adjusted, rather than sex and age groups. Important population differences about atherosclerosis and cardiovascular risk factors may thus be missed. We compare the distribution of cardiovascular risk factors, ...
    • Wrist malpractice claims in Northern Norway 2005–2014. Lessons to be learned 

      Norum, Jan; Balteskard, Lise; Thomsen, Mette Willumstad; Kvernmo, Hebe Desiree (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-18)
      Rough weather conditions in the subarctic areas of Norway may influence on the risk of wrist fracture. We implemented data from the Norwegian System of Patient Injury Compensation (NPE). All claims due to wrist surgery, performed at the public hospitals in Northern Norway, during 2005-2014 were analyzed. We employed the ICD-10 classification codes S52.5 (fracture of distal end of radius) and S52.6 ...
    • No improvement in depressive symptoms by vitamin D supplementation: results from a randomised controlled trial 

      Jorde, Rolf; Kubiak, Julia Magdalena (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-22)
      In observational studies, vitamin D deficiency is associated with depressive symptoms. However, randomised controlled trials (RCT) with vitamin D supplementation have not been conclusive. In the present study 206 subjects were randomised to vitamin D (100 000 IU (2500 µg) as a bolus dose followed by 20 000 IU (500 µg) per week) and 202 to placebo. The Beck Depression Inventory-II (BDI-II) was filled ...
    • Comparative exoproteome profiling of an invasive and a commensal Staphylococcus haemolyticus isolate 

      Cavanagh, Jorunn Pauline; Pain, Maria Charlene Ronessen; Askarian, Fatemeh; Bruun, Jack-Ansgar; Urbarova, Ilona; Wai, Sun Nyunt; Schmidt, Frank; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-22)
      Staphylococcus haemolyticus is a skin commensal emerging as an opportunistic pathogen. Nosocomial isolates of S. haemolyticus are the most antibiotic resistant members of the coagulase negative staphylococci (CoNS), but information about other S. haemolyticus virulence factors is scarce. Bacterial membrane vesicles (MVs) are one mediator of virulence by enabling secretion and long distance delivery ...
    • Dietary intake of marine n-3 polyunsaturated fatty acids and future risk of venous thromboembolism 

      Isaksen, Trond; Evensen, Line Holtet; Johnsen, Stein Harald; Jacobsen, Bjarne K.; Hindberg, Kristian; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
      <p><i>Background</i>: Studies on the association between long‐chained n‐3 polyunsaturated fatty acids (n‐3 PUFAs) and risk of venous thromboembolism (VTE) are conflicting, potentially due to challenges related to assessment of n‐3 PUFA intake and changes in diet during follow‐up.</p> <p><i>Objectives</i>: To investigate whether dietary intake of marine n‐3 PUFAs was associated with risk of incident ...
    • Repeated measurements of carotid atherosclerosis and future risk of venous thromboembolism: the Tromsø Study 

      Småbrekke, Birgit; Rinde, Ludvig Balteskard; Mathisen Hald, Erin; Njølstad, Inger; Mathiesen, Ellisiv B.; Johnsen, Stein Harald; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas; Lijfering, Willem M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-05)
      <p><i>Background</i>: Whether a relationship between atherosclerosis and subsequent venous thromboembolism (VTE) exists is controversial.</p> <p><i>Objective</i>: To investigate the association between carotid atherosclerosis and VTE by using repeated measurements of intima media thickness (IMT) and total plaque area (TPA) in participants recruited from the general population.</p> <p><i>Methods</i>: ...
    • Brief Report: The Genetic Profile of Rheumatoid Factor–Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis 

      Hinks, Anne; Marion, Miranda C.; Cobb, Joanna; Comeau, Mary E.; Sudman, Marc; Ainsworth, Hannah C.; Bowes, John; Becker, Mara L.; Bohnsack, John F.; Haas, Johannes-Peter; Lovell, Daniel J.; Mellins, Elizabeth D.; Nelson, J. Lee; Nordal, Ellen Berit; Punaro, Marilynn; Reed, Ann M.; Rose, Carlos D.; Rosenberg, Alan M.; Rygg, Marite; Smith, Samantha L.; Stevens, Anne M.; Videm, Vibeke; Wallace, Carol A.; Wedderburn, Lucy R.; Yarwood, Annie; Yeung, Rae S.M.; Langefeld, Carl D.; Thompson, Susan D.; Thomson, Wendy; Prahalad, Sampath (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-09)
      <i><p>Objective</i>: Juvenile idiopathic arthritis (JIA) comprises 7 heterogeneous categories of chronic childhood arthritides. Approximately 5% of children with JIA have rheumatoid factor (RF)–positive arthritis, which phenotypically resembles adult rheumatoid arthritis (RA). Our objective was to compare and contrast the genetics of RF‐positive polyarticular JIA with those of RA and selected other ...