Institutt for klinisk medisin: Nye registreringer

Viser treff 1161-1180 av 1802

    • Limb girdle muscular dystrophy type 2I: No correlation between clinical severity, histopathology and glycosylated α-dystroglycan levels in patients homozygous for common FKRP mutation 

      Alhamidi, Maisoon; Brox, Vigdis; Stensland, Eva; Liset, Merete; Lindal, Sigurd; Nilssen, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07)
      <p>Limb girdle muscular dystrophy type 2I (LGMD2I) is a progressive disorder caused by mutations in the FuKutin-Related Protein gene (FKRP). LGMD2I displays clinical heterogeneity with onset of severe symptoms in early childhood to mild calf and thigh hypertrophy in the second or third decade. Patients homozygous for the common FKRP mutation c.826C>A (p.Leu276Ile) show phenotypes within the milder ...

    • Visceral fat is strongly associated with post-transplant diabetes mellitus and glucose metabolism 1 year after kidney transplantation 

      Von Düring, Marit Elizabeth; Jenssen, Trond Geir; Bollerslev, Jens; Åsberg, Anders; Godang, Kristin; Hartmann, Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-16)
      Body composition after kidney transplantation is linked to glucose metabolism, and impaired glucose metabolism is associated with increased risk of cardiovascular events and death. One year after transplantation we examined 150 patients for new-onset diabetes performing OGTTs and body composition measurements including visceral adipose tissue (VAT) content from dual-energy X-ray absorptiometry ...

    • Neuropsychological functioning in a national cohort of severe traumatic brain injury: demographic and acute injury-related predictors 

      Sigurdardottir, Solrun; Andelic, Nada; Wehling, Eike; Røe, Cecilie; Anke, Audny; Skandsen, Toril; Holthe, Øyvor; Jerstad, Tone; Aslaksen, Per Matti; Schanke, Anne-Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
      Objectives: To determine the rates of cognitive impairment 1 year after severe traumatic brain injury (TBI) and to examine the influence of demographic, injury severity, rehabilitation, and subacute functional outcomes on cognitive outcomes 1 year after severe TBI.<p> Setting: National multicenter cohort study over 2 years.<p> Participants: Patients (N = 105), aged 16 years or older, with ...

    • Preserving the legacy of reirradiation: A narrative review of historical publications 

      Nieder, Carsten; Langendijk, Johannes A.; Guckenberger, Matthias; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-21)
      The purpose of this study is to illustrate the historical development of reirradiation during several decades of the 20th century, in particular between 1920 and 1960. <br> <br> Methods and materials: We chose the format of a narrative review because the historical articles are heterogeneous. No systematic extraction of baseline data, treatment details, or follow-up care was possible in many ...

    • Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function 

      Pischke, Søren Erik; Gustavsen, Alice; Orrem, Hilde Lang; Egge, Kjetil Hagene; Courivaud, Frederic A. A.; Fontenelle, Hugues; Despont, Alain; Bongoni, Anjan K.; Rieben, Robert; Tønnessen, Tor Inge; Nunn, Miles A.; Scott, Helge; Skulstad, Helge; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-03)
      Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while no benefit was found in clinical studies. Due to lack of cross-reactivity of clinically used C5 antibodies, different inhibitors were used in animal and clinical studies. Coversin (Ornithodoros moubata complement inhibitor, OmCI) blocks C5 cleavage and binds leukotriene B4 in humans and pigs. We hypothesized ...

    • A survey of national and multi-national registries and cohort studies in juvenile idiopathic arthritis: challenges and opportunities 

      Beukelman, Timothy; Anink, Janneke; Berntson, Lillemor; Duffy, Ciaran; Ellis, Justine A.; Glerup, Mia; Guzman, Jaime; Horneff, Gerd; Kearsley-Fleet, Lianne; Klein, Ariane; Klotsche, Jens; Magnusson, Bo; Minden, Kirsten; Munro, Jane E.; Niewerth, Martina; Nordal, Ellen Berit; Ruperto, Nicolino; Santos, Maria José; Schanberg, Laura E.; Thomson, Wendy; Suijlekom-Smit, Lisette van; Wulffraat, Nico; Hyrich, Kimme (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-19)
      Background: To characterize the existing national and multi-national registries and cohort studies in juvenile idiopathic arthritis (JIA) and identify differences as well as areas of potential future collaboration. <br> <br> Methods: We surveyed investigators from North America, Europe, and Australia about existing JIA cohort studies and registries. We excluded cross-sectional studies. We captured ...

    • Epidermal growth factor receptor signaling enhances the proinflammatory effects of staphylococcus aureus gamma-toxin on the mucosa 

      Gillman, Aaron N.; Breshears, Laura M.; Kistler, Charles K.; Finnegan, Patrick M.; Torres, Victor J.; Schlievert, Patrick M.; Peterson, Marnie L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-28)
      Staphylococcus aureus (S. aureus) produces many different exotoxins including the gamma-toxins, HlgAB and HlgCB. Gamma-toxins form pores in both leukocyte and erythrocyte membranes, resulting in cell lysis. The genes encoding gamma-toxins are present in most strains of S. aureus, and are commonly expressed in clinical isolates recovered from menstrual Toxic Shock Syndrome (mTSS) patients. This study ...

    • Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer 

      Kilvær, Thomas Karsten; Rakaee, Mehrdad; Hellevik, Turid; Østman, Arne; Strell, Carina; Bremnes, Roy M.; Busund, Lill-Tove; Dønnem, Tom; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-07)
      Objectives: <br> Selective targeting of cancer-associated fibroblasts (CAFs) has been proposed to synergize with immune-checkpoint inhibitors. While the roles of CAFs in cancer development are well described, their immune-regulatory properties remain incompletely understood. This study investigates correlations between CAF and immune-markers in tumor stroma from nonsmall cell lung cancer (NSCLC) ...

    • Involuntary admission in Norwegian adult psychiatric hospitals: A systematic review 

      Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)
      Background: It is an important objective of the psychiatric services to keep the use of involuntary procedures to a minimum, as the use of coercion involves clinical, ethical, and legal issues. It has been claimed that Norway has a relatively high rate of involuntary admissions. We reviewed the peer-reviewed literature on the use of involuntary admission in Norway, with the purpose of identifying ...

    • Fat in the multifidus muscles - predictive value and change following disc prosthesis surgery and multidisciplinary rehabilitation in patients with chronic low back pain and degenerative disc disease: 2 year follow-up of a randomized trial. 

      Storheim, Kjersti; Berg, Linda; Hellum, Christian; Gjertsen, Øivind; Neckelmann, Gesche; Espeland, Ansgar; Keller, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-14)
      Background: Evidence is lacking on whether fat infiltration in the multifidus muscles affects outcomes after total disc replacement (TDR) surgery and if it develops after surgery. The aims of this study were 1) to investigate whether pre-treatment multifidus muscle fat infiltration predicts outcome 2 years after treatment with TDR surgery or multidisciplinary rehabilitation, and 2) to compare changes ...

    • Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus 

      Lekva, Tove; Michelsen, Annika E.; Aukrust, Pål; Henriksen, Tore; Jens, Bollerslev; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-10)
      Background: Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life, but the mechanism remains unclear. Adipokine imbalance in the presence of metabolic dysfunction may be a key event in promoting CVD. The aim of the study was to examine the relationships between GDM, cardiovascular risk, and plasma adiponectin, leptin and the leptin/adiponectin ...

    • Responsibilities with conflicting priorities: A qualitative study of ACT providers’ experiences with community treatment orders 

      Stuen, Hanne Kilen; Landheim, Anne; Rugkåsa, Jorun; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-18)
      <p><i>Background - </i>Patients with severe mental illness may be subjected to Community Treatment Orders (CTOs) in order to secure that the patients adhere to treatment. Few studies have investigated the use of CTOs within an Assertive Community Treatment (ACT) setting, and little is known about how the tension between the patients’ autonomy and the clinicians’ responsibility to act in the patients’ ...

    • Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults 

      Bentham, James; Di Cesare, Mariachiara; Bilano, Ver; Bixby, Honor; Zhou, Bin; Stevens, Gretchen A.; Riley, Leanne M.; Taddei, Cristina; Hajifathalian, Kaveh; Lu, Yuan; Savin, Stefan; Cowan, Melanie J.; Paciorek, Christopher J.; Chirita-Emandi, Adela; Hayes, Alison J; Katz, Joanne; Kelishadi, Roya; Kengne, André Pascal; Khang, Young-Ho; Laxmaiah, Avula; Li, Yanping; Ma, Jun; Miranda, J. Jaime; Mostafa, Aya; Neovius, Martin; Padez, Cristina; Rampal, Lekhraj; Zhu, Aubrianna; Bennett, James E.; Danaei, Goodarz; Bhutta, Zulfiqar A.; Ezzati, Majid; Abarca-Gómez, Leandra; Abdeen, Ziad A.; Hamid, Zargar Abdul; Abu-Rmeileh, Niveen M.; Acosta-Cazares, Benjamin; Acuin, Cecilia; Adams, Robert J.; Aekplakorn, Wichai; Afsana, Kaosar; Aguilar-Salinas, Carlos A.; Agyemang, Charles; Ahmadvand, Alireza; Ahrens, Wolfgang; Ajlouni, Kamel; Akhtaeva, Nazgul; Al-Hazzaa, Hazzaa M.; Al-Othman, Amani Rashed; Al-Raddadi, Rajaa; AlBuhairan, Fadia S.; AlDhukair, Shahla; Ali, Mohamed M; Ali, Osman; Alkerwi, Ala'a; Alvarez-Pedrerol, Mar; Aly, Eman; Amarapurkar, Deepak N.; Amouyel, Philippe; Amuzu, Antoinette; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Andrade, Dolores S; Ängquist, Lars; Anjana, Ranjit Mohan; Aounallah-Skhiri, Hajer; Araújo, Joana; Ariansen, Inger Kristine; Aris, Tahir; Arlappa, Nimmathota; Arveiler, Dominique; Aryal, Krishna; Aspelund, Thor; Assah, Felix K.; Assunção, Maria Cecília; Aung, May Soe; Avdicová, Mária; Azevedo, Ana; Azizi, Fereidoun; Babu, Bontha V; Bahijri, Suhad; Baker, Jennifer L.; Balakrishna, Nagalla; Bamoshmoosh, Mohamed; Banach, Maciej; Bandosz, Piotr; Banegas, Jose R; Barbagallo, Carlo M.; Barcelo, Alberto; Barkat, Amina; Barros, Aluisio J.D.; Barros, Mauro V.G.; Bata, Iqbal; Biehl, Anna Månsson; Bjertness, Espen; Bjertness, Marius Bergsmark; Ekelund, Ulf; Graff-Iversen, Sidsel; Htet, Aung Soe; Janszky, Imre; Kolle, Elin; Krokstad, Steinar; Laugsand, Lars Erik; Mathiesen, Ellisiv B.; Meisfjord, Jørgen; Meyer, Haakon E.; Sen, Abhijit; Steene-Johannessen, Jostein; Vatten, Lars Johan; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-10)
      Background: <br> Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. <br>Methods: <br> ...

    • Antibiotic treatment In patients with chronic low back pain and Modic changes (the AIM study): study protocol for a randomised controlled trial. 

      Storheim, Kjersti; Espeland, Ansgar; Grøvle, Lars; Skouen, Jan Sture; Assmus, Jörg; Anke, Audny; Froholdt, Anne; Pedersen, Linda Margareth; Haugen, A. J.; Fors, Terese; Lutro, Olav; Marchand, Gunn Hege; Kadar, Thomas; Vetti, Nils; Randen, Solfrid; Nygaard, Øystein Petter; Brox, Jens Ivar; Grotle, Margreth; Zwart, John-Anker (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-15)
      Background: <br>A previous randomised controlled trial (RCT) of patients with chronic low back pain (LBP) and vertebral bone marrow (Modic) changes (MCs) on magnetic resonance imaging (MRI), reported that a 3-month, high-dose course of antibiotics had a better effect than placebo at 12 months’ follow-up. The present study examines the effects of antibiotic treatment in chronic LBP patients with ...

    • Short survival time after palliative whole brain radiotherapy: Can we predict potential overtreatment by use of a nomogram? 

      Nieder, Carsten; Norum, Jan; Hintz, Mandy; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-01)
      Background:<br> Many patients with brain metastases undergoing whole brain radiotherapy (WBRT) have very limited survival. The purpose of this study was to validate a nomogram derived from a large American database and to examine its ability to better predict short survival (cut -off 2 months) than previous models. <br>Material and Methods: <br> This retrospective study included 254 European patients ...

    • Blood pressure target achievement and antihypertensive medication use in women and men after first-ever myocardial infarction: the Tromsø Study 1994-2016 

      Hopstock, Laila Arnesdatter; Eggen, Anne Elise; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Nilsen, Amalie; Njølstad, Inger; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-03)
      Background: <br> Recurrent cardiovascular events after myocardial infarction (MI) are frequent, and gender differences in blood pressure treatment have been reported. Despite increased focus on secondary prevention, recent reports indicate that treatment targets are not achieved. There is a need for gender-specific analyses of post-MI blood pressure treatment target achievement and ...

    • Living with dead spaces: Closing complex posterior midline defects with midline-based perforator flaps 

      de Weerd, Louis; Solberg, Tore; Falch, Birgit Margrethe; Weum, Sven (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-01)

    • The marriage of sartorius and tensor fasciae latae in treating vascular prosthetic graft infections 

      Zoepke, Simone N.; de Weerd, Louis (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-20)
      Background: <br> Vascular prosthetic graft infection in the groin is associated with high morbidity and mortality. This article presents a case series on the use of 2 flaps in the treatment of this condition. <br>Methods:<br> Five patients, mean age 65 years (range, 49–74 years), with significant comorbidity were treated for an exposed and infected vascular prosthetic graft in the groin with a ...

    • Acute infection as a trigger for incident venous thromboembolism: Results from a population- based case- crossover study 

      Grimnes, Gro; Isaksen, Trond; Tichelaar, Ynse Ieuwe Gerardus Vladimir; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-21)
      Background:<br> A bidirectional relation exists between acute infection and immobilization, and both are triggers for venous thromboembolism (VTE). To what extent the association between infection and VTE‐risk is explained by immobilization is unknown. <br>Aims:<br> To investigate the impact of hospitalization with acute infection on the VTE‐risk in patients with and without concomitant ...

    • Complement in clinical medicine: Clinical trials, case reports and therapy monitoring 

      Ricklin, Daniel; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-31)
      Research during past decades made it evident that complement is involved in more tasks than fighting infections, but has important roles in other immune surveillance and housekeeping functions. If the balance between complement activation and regulation is out of tune, however, complement can quickly turn against the host and contribute to adverse processes that result in various clinical conditions. ...