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norskInstitutt for klinisk medisin: Nye registreringer
Viser treff 1221-1240 av 1850
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Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-10)Background: <br> Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. <br>Methods: <br> ... -
Antibiotic treatment In patients with chronic low back pain and Modic changes (the AIM study): study protocol for a randomised controlled trial.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-15)Background: <br>A previous randomised controlled trial (RCT) of patients with chronic low back pain (LBP) and vertebral bone marrow (Modic) changes (MCs) on magnetic resonance imaging (MRI), reported that a 3-month, high-dose course of antibiotics had a better effect than placebo at 12 months’ follow-up. The present study examines the effects of antibiotic treatment in chronic LBP patients with ... -
Short survival time after palliative whole brain radiotherapy: Can we predict potential overtreatment by use of a nomogram?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-01)Background:<br> Many patients with brain metastases undergoing whole brain radiotherapy (WBRT) have very limited survival. The purpose of this study was to validate a nomogram derived from a large American database and to examine its ability to better predict short survival (cut -off 2 months) than previous models. <br>Material and Methods: <br> This retrospective study included 254 European patients ... -
Blood pressure target achievement and antihypertensive medication use in women and men after first-ever myocardial infarction: the Tromsø Study 1994-2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-03)Background: <br> Recurrent cardiovascular events after myocardial infarction (MI) are frequent, and gender differences in blood pressure treatment have been reported. Despite increased focus on secondary prevention, recent reports indicate that treatment targets are not achieved. There is a need for gender-specific analyses of post-MI blood pressure treatment target achievement and ... -
Living with dead spaces: Closing complex posterior midline defects with midline-based perforator flaps
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-01) -
The marriage of sartorius and tensor fasciae latae in treating vascular prosthetic graft infections
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-20)Background: <br> Vascular prosthetic graft infection in the groin is associated with high morbidity and mortality. This article presents a case series on the use of 2 flaps in the treatment of this condition. <br>Methods:<br> Five patients, mean age 65 years (range, 49–74 years), with significant comorbidity were treated for an exposed and infected vascular prosthetic graft in the groin with a ... -
Acute infection as a trigger for incident venous thromboembolism: Results from a population- based case- crossover study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-21)Background:<br> A bidirectional relation exists between acute infection and immobilization, and both are triggers for venous thromboembolism (VTE). To what extent the association between infection and VTE‐risk is explained by immobilization is unknown. <br>Aims:<br> To investigate the impact of hospitalization with acute infection on the VTE‐risk in patients with and without concomitant ... -
Complement in clinical medicine: Clinical trials, case reports and therapy monitoring
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-31)Research during past decades made it evident that complement is involved in more tasks than fighting infections, but has important roles in other immune surveillance and housekeeping functions. If the balance between complement activation and regulation is out of tune, however, complement can quickly turn against the host and contribute to adverse processes that result in various clinical conditions. ... -
Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-25)Background: <br> Obesity is a global pandemic leading to increased mortality and increased risk of cardiovascular disease. Bariatric surgery is an established treatment of obesity leading to weight loss and reduction of mortality. To further elucidate how bariatric surgery improves metabolic control, we explored the fatty acid (FA) profiles in morbidly obese subjects treated with lifestyle ... -
Concurrent adversities and deliberate self-harm among indigenous Sami and majority Norwegian adolescents: the Norwegian Arctic Adolescent Health Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-13)Background: <br> Few studies have investigated proximal relationships between deliberate self-harm (DSH) and concurrent adversities.<br> Objective:<br> We aimed to investigate these relationships in a community population of 4881 indigenous Sami and majority Norwegian adolescents, 15 to 16 years old, and related to ethnicity and gender. <br>Methods: <br>Youth with and without self-reports of DSH ... -
Influence of a New “Call-Out Algorithm” for Management of Postoperative Pain and Its Side Effects on Length of Stay in Hospital: A Two-Centre Prospective Randomized Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-10)Background. We recently introduced the efficacy safety score (ESS) as a new “call-out algorithm” for management of postoperative pain and side effects. In this study, we report the influence of ESS recorded hourly during the first 8 hours after surgery on the mobility degree, postoperative nonsurgical complications, and length of hospital stay (LOS). Methods. We randomized 1152 surgical patients ... -
Preventing and treating medication overuse headache
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-01)The concept that headache treatment per se may be the cause of chronification of headache is not new,3 but our understanding of this concept, and the terminology defining it, have changed throughout the years. The criteria for MOH are based on expert consensus rather than formal evidence. According to the current definition in the latest (2013) International Classification of Headache Disorders–3 ... -
Comorbidity and outcomes of concurrent chemo- and radiotherapy in limited disease small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-23)<b>Background:</b> Many patients with limited disease small cell lung cancer (LD SCLC) suffer from comorbidity. Not all patients with comorbidity are offered standard treatment, though there is little evidence for such a policy. The aim of this study was to investigate whether patients with comorbidity had inferior outcomes in a LD SCLC cohort. <br><b>Material and methods:</b> We analyzed patients ... -
High number of kinome-mutations in non-small cell lung cancers associated with reduced immune response and poor relapse-free survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-07)Lung cancer is the leading cause of cancer related death, and the past years’ improved insight into underlying molecular events has significantly improved outcome for specific subsets of patients. In particular, several new therapies that target protein kinases have been implemented, and many more are becoming available. We have investigated lung cancer specimens for somatic mutations in a targeted ... -
Negotiating the boundaries of psychosis: A qualitative study of the service provider perspective on treatment delay in community mental health
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-23)Aim: <br>Evidence shows that many patients are detected and treated late in their course of illness, and that substantial delay occurs even after entry to mental health services. Although several studies have examined the service user and carer perspectives on treatment delay, few have explored the issue from the service provider perspective. The aim of this study was to broaden our understanding ... -
Early versus late-applied constraint-induced movement therapy: A multisite, randomized controlled trial with a 12-month follow-up
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-07)Background and Purpose: <p> A direct comparison between the effects of constraint‐induced movement therapy (CIMT) applied early after stroke and that of CIMT applied in the chronic phase has not been conducted. This study aimed to compare the long‐term effects of CIMT applied 6 months after stroke with the results of CIMT applied within 28 days post‐stroke. <br>Methods: <p> This study was a ... -
Muscle mass and association to quality of life in non-small cell lung cancer patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-10)Background<br> Cancer wasting is characterized by muscle loss and may contribute to fatigue and poor quality of life (QoL). Our aim was to investigate associations between skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD) and selected QoL outcomes in advanced non‐small cell lung cancer (NSCLC) at diagnosis.<p> Methods<br> Baseline data from patients with stage IIIB/IV NSCLC and ... -
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Alginate microbeads and microcapsules are presently under evaluation for future cell-based therapy. Defining their inflammatory properties with regard to humans is therefore essential. A lepirudine-based human whole blood model was used as an inflammation predictor by measuring complement and leukocyte stimulation. Alginate microbeads were complement-compatible since they did not activate complement ... -
Psoriasis and associated variables in classification and outcome of juvenile idiopathic arthritis - an eight-year follow-up study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-22)Background<br> To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA).<p> Methods<br> In all, 440 children with JIA were followed for a median of 8 years in a prospective Nordic population-based cohort study. Data for remission was available for 427 of these ... -
Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-01)Rationale:Antiphospholipid syndrome (APS) in pregnancy may trigger the lifethreatening catastrophic antiphospholipid syndrome (CAPS). Complement activation is implicated in the pathogenesis, and inhibition of complement factor C5 is suggested as an additional treatment option.<p> Patient concerns, diagnosis and interventions: We present a pregnant patient treated with the C5-inhibitor eculizumab ...
