Institutt for klinisk medisin: Nye registreringer
Viser treff 1321-1340 av 1850
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Utilisation of helicopter emergency medical services in the early medical response to major incidents: A systematic literature review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-09)Objective: This systematic review identifies, describes and appraises the literature describing the utilisation of helicopter emergency medical services (HEMS) in the early medical response to major incidents. <p> Setting: Early prehospital phase of a major incident. <p>Design: Systematic literature review performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses ... -
Hepatic Steatosis detected by Hepatorenal Index in Ultrasonography as a Predictor of Insulin Resistance in Obese Subjects
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-20)BACKGROUND: The metabolic syndrome is a worldwide health issue, with non-alcoholic fatty liver disease (liver steatosis) being one of its features, particularly closely related to insulin resistance. This study aims to investigate whether quantification of hepatic steatosis by abdominal ultrasonography, using hepatorenal index, is a feasible tool for the prediction of insulin resistance, and thus ... -
Longitudinal reference ranges for maternal plasma laeverin, and its role as a potential biomarker of preeclampsia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-25)Background: Laeverin is a placenta-specific membrane-bound aminopeptidase. In this study we wanted to: 1) serially measure plasma levels of laeverin in healthy women during the second half of pregnancy and postpartum, 2) determine whether laeverin is differently expressed at 22–24 weeks in women who later develop preeclampsia compared to controls, 3) compare laeverin protein expression in placenta ... -
Long-term integrated telerehabilitation of COPD Patients: A multicentre randomised controlled trial (iTrain)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-22)<i>Background</i>: Pulmonary rehabilitation (PR) is an effective intervention for the management of people with chronic obstructive pulmonary disease (COPD). However, available resources are often limited, and many patients bear with poor availability of programmes. Sustaining PR benefits and regular exercise over the long term is difficult without any exercise maintenance strategy. In contrast ... -
Tumor Necrosis Factor and the Tenacious α.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05) -
The distribution of hand fractures at the university hospital of north Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-06)BACKGROUND: The objective of this study was to describe the fracture pattern for hand fractures in the Arctic region of Norway. MATERIALS AND METHODS: Using the hospital's radiological information system and picture archiving and communication system all traumatic hand fractures in the year of 2010 were registered. Fractures in the carpal, metacarpal, and phalangeal bones were included in the ... -
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-22)Catastrophic antiphospholipid syndrome is associated with excessive complement activation explaining the clinical efficacy of complement inhibitory treatment. -
Acceptability, feasibility, and cost of telemedicine for nonacute headaches: A randomized study comparing video and traditional consultations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-30)<b>Backgr ound:</b> The feasibility of telemedicine in diagnosing and treating nonacute headaches, such as primary headaches (migraine and tension-type) and medication-overuse headaches has not been previously investigated. By eliminating the need of travel to specialists, telemedicine may of fer significant time and money ... -
Probable clozapine-induced parenchymal lung disease and perimyocarditis: A case report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-08)<p><i>Background:</i> Clozapine is the archetypical atypical antipsychotic, its primary indication being treatment resistant schizophrenia. Severe side effects caused by clozapine, including leukopenia, agranulocytosis, and myocarditis, are well known. A rarely described side effect is concurrent perimyocarditis and parenchymal lung disease. <p><i>Case presentation:</i> A previously physically ... -
Antibody-based targeting of alternatively spliced tissue factor: A new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016)Alternatively spliced Tissue Factor (asTF) is a secreted form of Tissue Factor (TF), the trigger of blood coagulation whose expression levels are heightened in several forms of solid cancer, including pancreatic ductal adenocarcinoma (PDAC). asTF binds to β1 integrins on PDAC cells, whereby it promotes tumor growth, metastatic spread, and monocyte recruitment to the stroma. In this study, we determined ... -
Analysis of the immune microenvironment in resected non-small cell lung cancer: The prognostic value of different T lymphocyte markers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016)The prognosis of non-small cell lung cancer (NSCLC) remains poor and heterogeneous and new biomarkers are needed. As the immune system plays a pivotal role in cancer, the study of immune-related markers may provide valuable prognostic information of NSCLC. In 122 formalin-fixed, paraffin-embedded tumor tissue samples from early-stage NSCLC, tumor and tumor-near stromal areas were microdissected and ... -
Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-31)The host is protected by pattern recognition systems, including complement and TLRs, which are closely cross-talking. If improperly activated, these systems might induce tissue damage and disease. Inhibition of single downstream proinflammatory cytokines, such as TNF, IL-1β, and IL-6, have failed in clinical sepsis trials, which might not be unexpected, given the substantial amounts of mediators ... -
Open discectomy vs microdiscectomy for lumbar disc herniation - a protocol for a pragmatic comparative effectiveness study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-02)Introduction:<br>Since the introduction of lumbar microdiscectomy in the 1970’s, many studies have attempted to compare the effectiveness of this method with that of standard open discectomy with conflicting results. This observational study is designed to compare the relative effectiveness of microdiscectomy (MD) with open discectomy (OD) for treating lumbar disc herniation, -within a large cohort, ... -
LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-15)Aims/hypothesis: Activation of inflammatory pathways is involved in the pathogenesis of type 2 diabetes mellitus. On the basis of its role in vascular inflammation and in metabolic disorders, we hypothesised that the TNF superfamily (TNFSF) member 14 (LIGHT/TNFSF14) could be involved in the pathogenesis of type 2 diabetes mellitus. <p>Methods: Plasma levels of LIGHT were measured in two cohorts of ... -
Magnetic resonance volumetry: prediction of subjective memory complaints and mild cognitive impairment, and associations with genetic and cardiovascular risk factors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-25)<i>Background/Aims</i>: Subjective memory complaints (SMC) are strong predictors of mild cognitive impairment (MCI) and subsequent Alzheimer’s disease. Our aims were to see if fully automated cerebral MR volume measurements could distinguish subjects with SMC and MCI from controls, and if probable parental late-onset Alzheimer’s disease (LOAD), apolipoprotein E ε4 genotype, total plasma homocysteine, ... -
Characterization of BRCA1 and BRCA2 variants found in a Norwegian breast or ovarian cancer cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-05)Germline mutations in BRCA1 and BRCA2 cause hereditary breast and ovarian cancer. Molecular screening of these two genes in patients with a family history of breast or ovarian cancer has revealed pathogenic variants as well as genetic variants of unknown significance (VUS). These VUS may cause a challenge in the genetic counseling process regarding clinical management of the patient and the family. ... -
A longitudinal follow-up of autoimmune polyendocrine syndrome type 1
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-02)<b>Context:</b> Autoimmune polyendocrine syndrome type 1 (APS1) is a childhood-onset monogenic disease defined by the presence of two of the three major components: hypoparathyroidism, primary adrenocortical insuffi- ciency, and chronic mucocutaneous candidiasis (CMC). Information on longitudinal follow-up of APS1 is sparse. <b>Objective:</b> To describe the phenotypes of APS1 and correlate the ... -
Survival and symptom relief after palliative radiotherapy for esophageal cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-01)<b>Purpose:</b> The aim of this study was to assess the 6-months dysphagia-free survival, improvement in swallowing function, complication rate, and overall survival in patients with incurable esophageal cancer treated with palliative radiotherapy. <b>Methods:</b> We retrospectively reviewed data from 139 patients (median age 72 years) with advanced/recurrent incurable esophageal cancer, who were ... -
Bradykinin-Induced Shock Increase Exhaled Nitric Oxide, Complement Activation and Cytokine Production in Pigs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-04)Bradykinin is an important mediator in blood pressure regulation, ischemic precondition and capillary leakage, allergy, anaphylaxis, inflammation, and nociception, at least partly via the generation of nitric oxide (NO). Macrophages are particularly abundant in the porcine lung circulation. Upon bradykinin binding macrophages release cytokines and endothelial ... -
Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-09)A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is recommended by Kidney Disease: Improving Global Outcomes guidelines in specific populations (anorectic, cirrhotic, obese, renal and non-renal transplant patients) where estimation equations are unreliable. Measured GFR is the ...