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Altered pharmacological effects of adrenergic agonists during hypothermia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-05)Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiac dysfunction, calling for immediate pharmacologic intervention. Studies show that although cardiac pharmacologic support is applied when rewarming these patients, a lack of updated treatment recommendations exist. Mainly due to lack of clinical and experimental data, neither of the international guidelines ... -
Autologous chondrocyte implantation for hip osteochondritis functioning 15 years after operation
(Journal article; Tidsskriftartikkel, 2016-11-30)<b>Background:</b> The autologous implantation technique (ACI) was first introduced in studies on cartilage defects in knees. It has later been used for the treatment of osteochondral knee lesions. The patient presented here had a hip osteochondral defect measuring 4 cm in diameter. He was a candidate for hip prosthesis because of serious pain and reduced function. Being young and highly motivated ... -
Women with coronary heart disease – making sense of their symptoms and their experiences from interacting with their general practitioners
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-01)Cardiovascular disease and particularly coronary heart disease (CHD) is the leading cause of death among women and men worldwide. CHD in women, and their symptoms and treatment trajectory are not well understood. Studies indicate gender-related differences in symptom presentation, comorbidity, help-seeking behavior, and the quality of diagnostics and treatment of CHD. Although the incidence ... -
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-16)The inflammatory potential of 12 types of alginate-based microspheres was assessed in a human whole blood model. The inflammatory potential could be categorized from low to high based on the four main alginate microsphere types; alginate microbeads, liquefied core poly-l-ornithine (PLO)-containing microcapsules, liquefied core poly-l-lysine (PLL)-containing microcapsules, and solid core PLL-containing ... -
Glucosamine exposure reduces proteoglycan synthesis in primary human endothelial cells in vitro
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-23)<b>Purpose:</b> Glucosamine (GlcN) supplements are promoted for medical reasons, for example, for patients with arthritis and other joint-related diseases. Oral intake of GlcN is followed by uptake in the intestine, transport in the circulation and thereafter delivery to chondrocytes. Here, it is postulated to have an effect on synthesis and turnover of extracellular matrix constituents expressed ... -
Internet-based provider-patient communication in Ghana: recent findings
(Conference object; Konferansebidrag, 2016-11-15)While most people in the West have had easy access to the Internet for some time [1], with the dissemination of smart phones with Internet access this is now also rapidly becoming the case in West Africa [2]. Until recently, provider-patient communication has typically taken the form of face-toface interactions or telephone calls [3]. In Africa, the Internet and especially the social media are ... -
N-Acetyl-β-D-Glucosaminidase Does Not Enhance Prediction of Cardiovascular or All-Cause Mortality by Albuminuria in a Low-Risk Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-05)Albuminuria is a well known risk factor for cardiovascular disease and mortality, but focus on renal tubular dysfunction as a potential risk factor is growing also. The association between the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) and cardiovascular risk has been assessed mostly in cross-sectional studies. We studied the cross-sectional associations between urinary NAG and cardiovascular ... -
Ischemic Stroke and Risk of Venous Thromboembolism in the General Population: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-07)<i>Background</i> - Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population-based cohort.<p> <p><i>Methods and Results</i> - Participants (n=30 ... -
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-10)<p><i>Background - </i>Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition ... -
Relationships between learning approach, procrastination and academic achievement amongst first-year university students
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-22)Individual differences in student learning influence academic performance, and two aspects influencing the learning process are the particular learning approach the students use and procrastination behaviour. We examined the relationships between learning approaches, procrastination and academic achievement (measured 1 year later as the grade point average (GPA)) amongst 428 first-year university ... -
The Use of eHealth and Provider-Based Health Services by Patients with Diabetes Mellitus: Protocol for a Cross-Sectional Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-31)<b>Background:</b> The prevalence of diabetes and the use of electronic health (eHealth) resources are increasing. People with diabetes need frequent monitoring and follow-up of health parameters, and eHealth services can be of great significance in this regard. However, little is known about the extent to which different kinds of eHealth tools are used, and how the use of eHealth is associated ... -
Embodied health practices:The use of Traditional Healing and Conventional Medicine in a North Norwegian Community
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-11)Scandinavian welfare states like Norway represent a cultural context in which citizens who become ill are supposed to trust and receive health care within the conventional health care system that is officially subsidized and based on biomedical knowledge. Despite this officially initiated health practice, unofficial and non-commercial health practices exist in many North Norwegian communities, ... -
Plasmapheresis in severe sepsis and septic shock: a prospective, randomised, controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2002-07-23)Objective: To determine the therapeutic efficacy and safety of plasmapheresis in the treatment of patients with severe sepsis and septic shock. <br>Design: Prospective, randomised, clinical trial with a planned, midstudy, interim analysis. <br>Setting: Intensive care unit in a university hospital in Archangels, Russia. <br>Patients: Consecutive patients with severe sepsis or septic shock. <br ... -
Loss of interleukin 33 expression in colonic crypts- a potential marker for disease remission in ulcerative colitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-17)Interleukin 33 (IL-33) is a cytokine preferentially elevated in acute ulcerative colitis (UC), inferring a role in its pathogenesis. The role of IL-33 in intestinal inflammation is incompletely understood, with both pro-inflammatory and regulatory properties described. There are also conflicting reports on cellular sources and subcellular location of IL-33 in the colonic mucosa, justifying a closer ... -
Tertiary education and its association with mental health indicators and educational factors among Arctic young adults: the NAAHS cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-27)<b>Background. </b>Completed tertiary education is closely associated with employment and influences income, health and personal well-being. <br> <b>Objective. </b>The purpose of the study is to explore predictors for completed tertiary education among indigenous Sami and non-indigenous young people in relation to mental health indicators and educational factors in sociocultural rural and urban ... -
Non-completion of upper secondary school among female and male young adults in an Arctic sociocultural context; the NAAHS study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-13)<b>BACKGROUND: </b> Education is closely associated with health. Non-completion of upper secondary school influences academic achievement, employment, income and personal well-being. The purpose of the study is to explore predictors of non-completion of upper secondary school among female and male young adults in relation to mental health and educational factors in a socio-cultural, Arctic ... -
Use of social media for sexual health promotion: a scoping review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-19)<b>Background: </b> <br> In order to prevent sexually transmitted infections (STIs), the World Health Organization recommends educating people on sexual health. With more than 2 billion active users worldwide, online social media potentially represent powerful channels for health promotion, including sexual health. <br> <b>Objective: </b> <br> To review the scientific literature on the use of ... -
CD4 cell count and CD4/CD8 ratio increase during rituximab maintenance in Granulomatosis with polyangiitis patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-20)<b>Introduction</b> <br> Rituximab (RTX) is a B cell-depleting agent approved for the treatment of granulomatosis with polyangiitis (GPA). RTX reduces antibody producing precursor plasma cells and inhibits B and T cells interaction. Infections related to T cell immunodeficiency are not infrequent during RTX treatment. Our study investigated CD4 cell count and CD4/CD8 ratio in GPA patients during the ... -
Arm Crank and Wheelchair Ergometry Produce Similar Peak Oxygen Uptake but Different Work Economy Values in Individuals with Spinal Cord Injury
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-20)<i>Objective. </i> To study whether values for peak oxygen uptake (VO<sub>2peak</sub>) and work economy (WE) at a standardized workload are different when tested by arm crank ergometry (ACE) and wheelchair ergometry (WCE). <i>Methods. </i> Twelve paraplegic men with spinal cord injury (SCI) in stable neurological condition participated in this cross-sectional repeated-measures study. We determined ... -
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-13)INTRODUCTION: Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression would present with a specific and different serum and cerebrospinal fluid (CSF) cytokine profile compared to 21 patients with diffuse neurological symptoms, of whom 15 had fatigue as ...
