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dc.contributor.authorHovda, Tone
dc.contributor.authorSagstad, Silje
dc.contributor.authorLarsen, Marthe
dc.contributor.authorChen, Yan
dc.contributor.authorHofvind, Solveig Sand-Hanssen
dc.date.accessioned2024-02-19T10:20:36Z
dc.date.available2024-02-19T10:20:36Z
dc.date.issued2023-05-28
dc.description.abstractBackground - Double reading of screening mammograms is associated with a higher rate of screen-detected cancer than single reading, but different strategies exist regarding reader pairing and blinding. Knowledge about these aspects is important when considering strategies for future use of artificial intelligence in mammographic screening.<p> <p>Purpose - To investigate screening outcome, histopathological tumor characteristics, and mammographic features stratified by the first and the second reader in a population based screening program for breast cancer.<p> <p>Material and Methods - The study sample consisted of data from 3,499,048 screening examinations from 834,691 women performed during 1996–2018 in BreastScreen Norway. All examinations were interpreted independently by two radiologists, 272 in total. We analyzed interpretation score, recall, and cancer detection, as well as histopathological tumor characteristics and mammographic features of the cancers, stratified by the first and second readers.<p> <p>Results - For Reader 1, the rate of positive interpretations was 4.8%, recall 2.3%, and cancer detection 0.5%. The corresponding percentages for Reader 2 were 4.9%, 2.5%, and 0.5% (P < 0.05 compared with Reader 1). No statistical difference was observed for histopathological tumor characteristics or mammographic features when stratified by Readers 1 and 2. Recall and cancer detection were statistically higher and histopathological tumor characteristics less favorable for cases detected after concordant positive compared with discordant interpretations.<p> <p>Conclusion - Despite reaching statistical significance, mainly due to the large study sample, we consider the differences in interpretation scores, recall, and cancer detection between the first and second readers to be clinically negligible. For practical and clinical purposes, double reading in BreastScreen Norway is independent.en_US
dc.identifier.citationHovda, Sagstad, Larsen, Chen, Hofvind. Screening outcome for interpretation by the first and second reader in a population-based mammographic screening program with independent double reading. Acta Radiologica. 2023en_US
dc.identifier.cristinIDFRIDAID 2161677
dc.identifier.doi10.1177/02841851231176272
dc.identifier.issn0284-1851
dc.identifier.issn1600-0455
dc.identifier.urihttps://hdl.handle.net/10037/32975
dc.language.isoengen_US
dc.publisherSAGE Publicationsen_US
dc.relation.journalActa Radiologica
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.titleScreening outcome for interpretation by the first and second reader in a population-based mammographic screening program with independent double readingen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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