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dc.contributor.authorRypdal, Veronika Gjertsen
dc.contributor.authorGlerup, Mia
dc.contributor.authorRypdal, Martin Wibe
dc.contributor.authorArnstad, Ellen Dalen
dc.contributor.authorAalto, Kristiina
dc.contributor.authorBerntson, Lillemor
dc.contributor.authorFasth, Anders
dc.contributor.authorHerlin, Troels
dc.contributor.authorMyrup, Charlotte
dc.contributor.authorPeltoniemi, Suvi
dc.contributor.authorRygg, Marite
dc.contributor.authorNordal, Ellen Berit
dc.date.accessioned2024-09-23T09:10:33Z
dc.date.available2024-09-23T09:10:33Z
dc.date.issued2024-03-08
dc.description.abstractObjectives To identify long-term disease activity trajectories from childhood to adulthood by using the clinical Juvenile Arthritis Disease Activity Score (cJADAS10) in juvenile idiopathic arthritis (JIA). Second, to evaluate the contribution of the cJADAS10 components and explore characteristics associated with active disease at the 18- year follow-up.<p> <p>Methods Patients with onset of JIA in 1997–2000 were followed for 18 years in the population-based Nordic JIA cohort. We used a discrete mixture model for longitudinal clustering of the cJADAS10 and its components. We assessed factors potentially associated with higher scores on the patient’s global assessment of well-being (PaGA) by hierarchical clustering and correlation analysis. <p>Results Four disease activity trajectories were identified based on the cJADAS10 components among 427 patients. In trajectory-group 2, the PaGA and the physician’s global assessment of disease activity (PhGA) increased significantly during the course, but not the active joint count. The increase in the PaGA was significantly higher than the increases in the PhGA and the active joint count (p<0.0001). A similar pattern was found among all the patients with active disease in the total cohort. Patients with higher PaGA scores had unfavourable scores on several other patient-reported outcomes. <p>Conclusions We have identified groups of patients based on long-term disease activity trajectories. In our study the PaGA was the most important driver of disease activity into adulthood assessed by cJADAS10. We need to better understand how our patients interpret global well-being and implement strategies to achieve inactive disease perceived both by the patient and the physician.en_US
dc.identifier.citationRypdal, Glerup, Rypdal, Arnstad, Aalto, Berntson, Fasth, Herlin, Myrup, Peltoniemi, Rygg, Nordal. Disease activity trajectories from childhood to adulthood in the population-based Nordic juvenile idiopathic arthritis cohort. RMD Open. 2024;10(1)en_US
dc.identifier.cristinIDFRIDAID 2258565
dc.identifier.doi10.1136/rmdopen-2023-003759
dc.identifier.issn2056-5933
dc.identifier.urihttps://hdl.handle.net/10037/34826
dc.language.isoengen_US
dc.publisherBMJen_US
dc.relation.journalRMD Open
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.titleDisease activity trajectories from childhood to adulthood in the population-based Nordic juvenile idiopathic arthritis cohorten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)