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dc.contributor.authorJenberie, Shiferaw
dc.contributor.authorNordli, Henriette R.
dc.contributor.authorStrandskog, Guro
dc.contributor.authorGreiner-Tollersrud, Linn
dc.contributor.authorPenaranda, Ma Michelle Demogina
dc.contributor.authorJørgensen, Jorunn B
dc.contributor.authorJensen, Ingvill
dc.date.accessioned2024-10-02T10:18:48Z
dc.date.available2024-10-02T10:18:48Z
dc.date.issued2024-05-08
dc.description.abstractThe development and persistence of antibody secreting cells (ASC) after antigenic challenge remain inadequately understood in teleosts. In this study, intraperitoneal (ip) injection of Atlantic salmon (Salmo salar) with salmonid alphavirus (WtSAV3) increased the total ASC response, peaking 3–6 weeks post injection (wpi) locally in the peritoneal cavity (PerC) and in systemic lymphoid tissues, while at 13 wpi the response was only elevated in PerC. At the same time point a specific ASC response was induced by WtSAV3 in PerC and systemic tissues, with the highest frequency in PerC, suggesting a local role. Inactivated SAV (InSAV1) induced comparatively lower ASC responses in all sites, and specific serum antibodies were only induced by WtSAV3 and not by InSAV1. An InSAV1 boost did not increase these responses. Expression of immune marker genes implies a role for PerC adipose tissue in the PerC immune response. Overall, the study suggests the Atlantic salmon PerC as a secondary immune site and an ASC survival niche.en_US
dc.identifier.citationJenberie, Nordli, Strandskog, Greiner-Tollersrud, Penaranda MMD, Jørgensen, Jensen. Virus-specific antibody secreting cells reside in the peritoneal cavity and systemic immune sites of Atlantic salmon (Salmo salar) challenged intraperitoneally with salmonid alphavirus. Developmental and Comparative Immunology. 2024;157en_US
dc.identifier.cristinIDFRIDAID 2271913
dc.identifier.doi10.1016/j.dci.2024.105193
dc.identifier.issn0145-305X
dc.identifier.issn1879-0089
dc.identifier.urihttps://hdl.handle.net/10037/34966
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalDevelopmental and Comparative Immunology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleVirus-specific antibody secreting cells reside in the peritoneal cavity and systemic immune sites of Atlantic salmon (Salmo salar) challenged intraperitoneally with salmonid alphavirusen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)