Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed by the non-enzymatic reaction between amino acids and reducing sugars, or dicarbonyls as intermediate compounds. Experimental studies suggest that AGEs may promote colorectal cancer, but prospective epidemiologic studies are inconclusive. We conducted a case–control study nested within a large European cohort. Plasma ...

Kapittelet beskriver risiko for hjerte- og karsykdommer blant samer og ikke-samer i Nord-Norge og bygger i hovedsak på tre artikler som er inkludert i doktorgradsavhandlingen til Susanna Ragnhild Andersdatter Siri. Datagrunnlaget er informasjon fra spørreskjema, kliniske undersøkelser og blodprøver som ble samlet inn ved helse- og levekårsundersøkelsene SAMINOR 1 og 2, som ble utført i henholdsvis ...

Background: NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention with drug-eluting stents (DES) or bare-metal stents (BMS) with a 5-year follow-up. Among the patients, 5,512 had measured either fasting glucose level or percent glycated hemoglobin (HbA1c) at the index procedure. That cohort constitutes the present study population analyzing mortality and evaluating treatment ...

Background. Despite considerable efforts, health disparities between people with high and low socioeconomic status (SES) have not changed over the past decades in The Netherlands. To create a culture of health and an environment in which all people can flourish, a shift in focus is needed from disease management towards health promotion. The Bolk model for Positive Health and Living Environment ...

Introduction: Major life changing events such as the COVID-19 pandemic may have major impact on one’s health and general well-being. This study aimed to determine the prevalence and predictive factors, including gender specifc diferences, of Complementary Medicine (CM) use (including CM consultations, self-care management and self-help techniques) during the frst wave of the COVID-19 pandemic in ...

In western industrialised societies, asymptomatic individuals are increasingly labelled as at-risk of future illness and targeted for public health interventions. These at-risk people are identified through health checks, population studies and national screening programs. The main purpose of communicating such risk to individuals is to motivate them to make lifestyle changes. Many of these risk-labels ...

Background: A healthy diet throughout the life course improves health and reduces the risk of disease. There is a need for new knowledge of the relation between diet and health, but existing methods to collect information on food and nutrient intake have their limitations. Evaluations of new tools to assess dietary intake are needed, especially in old people, where the introduction of new technology ...

Following the COVID-19 pandemic, Denmark introduced repeated lockdowns of society, including outreach services and visits from social workers for people living with mental illnesses. Based on ethnographic fieldwork, in this article we explore how people with mental illness react to and manage their lives amid COVID-19 mitigations, focusing on how they experience and negotiate vulnerability at ...

Background and objective: Andrographis paniculata (AP) is a traditionally used herbaceous plant, whose main active constituent is andrographolide. Andrographolide derivative medications and herbal preparations of AP are often used to treat respiratory tract infections. This study aims to systematically evaluate the safety of andrographolide derivative medications and herbal preparations of AP ...

Hjerteinfarkt og atrieflimmer er ledende årsaker til mortalitet og morbiditet globalt (1). Det norske dødsårsaksregisteret viser imidlertid at risiko for å dø av hjerte- og kar- sykdommer er mer enn halvert fra år 2000 til 2016 (2). Mannsverk et al. viste i 2012 at nedgangen i mortalitet av koronarsykdom i Tromsø skyldes en nedgang i insidens (3). Senere ble det vist at 66 % av nedgangen ...