Androgen receptors and sociosexual behaviors in mammals: The limits of generalization
Permanent lenke
https://hdl.handle.net/10037/35117Dato
2024-01-03Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Ågmo, Anders jSammendrag
Circulating testosterone is easily aromatized to estradiol and reduced to dihydrotestosterone in target tissues and
elsewhere in the body. Thus, the actions of testosterone can be mediated either by the estrogen receptors, the
androgen receptor or by simultaneous action at both receptors. To determine the role of androgens acting at the
androgen receptor, we need to eliminate actions at the estrogen receptors. Alternatively, actions at the androgen
receptor itself can be eliminated. In the present review, I will analyze the specific role of androgen receptors in
male and female sexual behavior as well as in aggression. Some comments about androgen receptors and social
recognition are also made. It will be shown that there are important differences between species, even between
strains within a species, concerning the actions of the androgen receptor on the behaviors mentioned. This fact
makes generalizations from one species to another or from one strain to another very risky. The existence of
important species differences is often ignored, leading to many misunderstandings and much confusion.
Forlag
ElsevierSitering
Ågmo. Androgen receptors and sociosexual behaviors in mammals: The limits of generalization. Neuroscience and Biobehavioral Reviews. 2024;157Metadata
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