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dc.contributor.authorMarin, Peter Michael
dc.contributor.authorMunyeme, Musso
dc.contributor.authorKankya, Clovice
dc.contributor.authorJubara, Ambrose Samuel
dc.contributor.authorMatovu, Enock
dc.contributor.authorWaiswa, Peter
dc.contributor.authorSanchez Romano, Javier
dc.contributor.authorMutebi, Francis
dc.contributor.authorOnafruo, David
dc.contributor.authorKitale, Estella
dc.contributor.authorBenard, Owori
dc.contributor.authorBuhler, Kayla Joy
dc.contributor.authorTryland, Morten
dc.date.accessioned2024-10-09T14:29:09Z
dc.date.available2024-10-09T14:29:09Z
dc.date.issued2024-07-15
dc.description.abstractBackground - Tuberculosis medication nonadherence is a multi-dimensional public health problem with serious consequences worldwide. There is little information available for medication nonadherence in South Sudan. This study assessed the proportion, reasons, and associated factors for nonadherence among patients with TB in Wau Municipality, South Sudan.<p> <p>Methods - A health facility based cross-sectional study was conducted among 234 tuberculosis (TB) patients receiving first line anti-TB regimen in Wau Municipality. Urine isoniazid metabolite testing (IsoScreen®) was used to determine nonadherence (visualized by negative test results) and a questionnaire was used to describe the reasons for nonadherence. Modified poisson regression with robust standard errors was performed since the proportion of nonadherence was < 10%, to identify nonadherence associated factors using the WHO Multidimensional adherence model.<p> <p>Results - Out of 234 participants, 24.8% (95% CI, 19.2 − 30.3) were nonadherent to the TB treatment regimen. At multivariate analysis, nonadherence was significantly associated with: relief of symptoms (APR 1.93, 95% CI 1.12 − 3.34, p = 0.018), alcohol use (APR 2.12, 95% CI 1.33 − 3.96, p = 0.019) and waiting time to receive drugs (APR 1.77, 95% CI 1.11 − 2.83, p = 0.017).<p> <p>Conclusion - Tuberculosis medication nonadherence was high, and it’s associated with patients’ relived of symptoms, alcohol use, and prolonged waiting time at health facility. Hence, addressing these barriers and the use of multifaceted interventions e.g. counseling, health education and improve appointments are crucial to reduce nonadherence among patients with TB in South Sudan.en_US
dc.identifier.citationMarin, Munyeme, Kankya, Jubara, Matovu, Waiswa, Sanchez Romano, Mutebi, Onafruo, Kitale, Benard, Buhler, Tryland. Medication nonadherence and associated factors in patients with tuberculosis in Wau, South Sudan: a cross- sectional study using the world health organization multidimensional adherence model. Archives of Public Health. 2024;82(1)en_US
dc.identifier.cristinIDFRIDAID 2289452
dc.identifier.doi10.1186/s13690-024-01339-9
dc.identifier.issn0778-7367
dc.identifier.issn2049-3258
dc.identifier.urihttps://hdl.handle.net/10037/35164
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalArchives of Public Health
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleMedication nonadherence and associated factors in patients with tuberculosis in Wau, South Sudan: a cross- sectional study using the world health organization multidimensional adherence modelen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)