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dc.contributor.authorNieder, Carsten
dc.contributor.authorAanes, Siv Gyda
dc.contributor.authorStanisavljevic, Luka
dc.contributor.authorMannsåker, Bård
dc.contributor.authorHaukland, Ellinor Christin
dc.date.accessioned2024-11-05T08:21:26Z
dc.date.available2024-11-05T08:21:26Z
dc.date.issued2024-10-01
dc.description.abstractPurpose The study’s purpose was to analyze return to work and other long-term outcomes in younger patients with newly diagnosed brain metastases, treated before they reached legal retirement age, i.e. younger than 65 years.<p> <p>Methods We included patients who survived greater than 2 years after their first treatment, regardless of approach (systemic therapy, neurosurgical resection, whole-brain or stereotactic radiotherapy). The primary endpoint was the proportion of patients who worked 2 years after their initial treatment for brain metastases. Outcomes beyond the 2-year cut-of were also abstracted from comprehensive electronic health records, throughout the follow-up period. <p>Results Of 455 patients who received active therapy for brain metastases, 62 (14%) survived for>2 years. Twenty-eight were younger than 65 years. The actuarial median survival was 81 months and the 5-year survival rate 53%. For patients alive after 5 years, the 10-year survival rate was 54%. At diagnosis, 25% of patients (7 of 28) were permanently incapacitated for work/retired. Of the remaining 21 patients, 33% did work 2 years later. However, several of these patients went on to receive disability pension afterwards. Eventually, 19% continued working in the longer run. Younger age, absence of extracranial metastases, presence of a single brain metastasis, and Karnofsky performance status 90–100 were common features of patients who worked after 2 years. <p>Conclusion Long-term survival was achieved after vastly different therapeutic approaches, regarding both upfront and sequential management. Many patients required three or more lines of brain-directed treatment. Few patients continued working in the longer run.en_US
dc.identifier.citationNieder, Aanes, Stanisavljevic, Mannsåker, Haukland. Return to work in younger patients with brain metastases who survived for 2 years or more. Journal of Neuro-Oncology. 2024en_US
dc.identifier.cristinIDFRIDAID 2312402
dc.identifier.doi10.1007/s11060-024-04840-x
dc.identifier.issn0167-594X
dc.identifier.issn1573-7373
dc.identifier.urihttps://hdl.handle.net/10037/35437
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalJournal of Neuro-Oncology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleReturn to work in younger patients with brain metastases who survived for 2 years or moreen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)