dc.contributor.author | Nieder, Carsten | |
dc.contributor.author | Aanes, Siv Gyda | |
dc.contributor.author | Stanisavljevic, Luka | |
dc.contributor.author | Mannsåker, Bård | |
dc.contributor.author | Haukland, Ellinor Christin | |
dc.date.accessioned | 2024-11-05T08:21:26Z | |
dc.date.available | 2024-11-05T08:21:26Z | |
dc.date.issued | 2024-10-01 | |
dc.description.abstract | Purpose The study’s purpose was to analyze return to work and other long-term outcomes in younger patients with newly
diagnosed brain metastases, treated before they reached legal retirement age, i.e. younger than 65 years.<p>
<p>Methods We included patients who survived greater than 2 years after their first treatment, regardless of approach (systemic
therapy, neurosurgical resection, whole-brain or stereotactic radiotherapy). The primary endpoint was the proportion of
patients who worked 2 years after their initial treatment for brain metastases. Outcomes beyond the 2-year cut-of were also
abstracted from comprehensive electronic health records, throughout the follow-up period.
<p>Results Of 455 patients who received active therapy for brain metastases, 62 (14%) survived for>2 years. Twenty-eight were
younger than 65 years. The actuarial median survival was 81 months and the 5-year survival rate 53%. For patients alive
after 5 years, the 10-year survival rate was 54%. At diagnosis, 25% of patients (7 of 28) were permanently incapacitated for
work/retired. Of the remaining 21 patients, 33% did work 2 years later. However, several of these patients went on to receive
disability pension afterwards. Eventually, 19% continued working in the longer run. Younger age, absence of extracranial
metastases, presence of a single brain metastasis, and Karnofsky performance status 90–100 were common features of
patients who worked after 2 years.
<p>Conclusion Long-term survival was achieved after vastly different therapeutic approaches, regarding both upfront and
sequential management. Many patients required three or more lines of brain-directed treatment. Few patients continued
working in the longer run. | en_US |
dc.identifier.citation | Nieder, Aanes, Stanisavljevic, Mannsåker, Haukland. Return to work in younger patients with brain metastases who survived for 2 years or more. Journal of Neuro-Oncology. 2024 | en_US |
dc.identifier.cristinID | FRIDAID 2312402 | |
dc.identifier.doi | 10.1007/s11060-024-04840-x | |
dc.identifier.issn | 0167-594X | |
dc.identifier.issn | 1573-7373 | |
dc.identifier.uri | https://hdl.handle.net/10037/35437 | |
dc.language.iso | eng | en_US |
dc.publisher | Springer Nature | en_US |
dc.relation.journal | Journal of Neuro-Oncology | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2024 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | Return to work in younger patients with brain metastases who survived for 2 years or more | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |