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dc.contributor.authorMørkved, Nina
dc.contributor.authorJohnsen, Erik
dc.contributor.authorKroken, Rune Andreas
dc.contributor.authorJoa, Inge
dc.contributor.authorKjelby, Eirik
dc.contributor.authorRettenbacher, M.A.
dc.contributor.authorBartz-Johannessen, Christoffer
dc.contributor.authorLøberg, Else-Marie
dc.date.accessioned2024-11-05T14:15:09Z
dc.date.available2024-11-05T14:15:09Z
dc.date.issued2024-08-31
dc.description.abstractTreatment with antipsychotics (APs) for schizophrenia spectrum disorders (SSDs) is generally effective, however, a significant proportion does not respond favorably. Childhood trauma (CT) subtypes (physical, sexual, and emotional abuse, physical and emotional neglect) could influence treatment effectiveness; however, research is scarce. Heterogeneity in AP response could be explained by differentiating by CT subtype. The present study was based on the Bergen-Stavanger-Trondheim-Innsbruck (BeSt InTro) study. CTQ-SF assessed CT subtypes in SSDs (n = 98). CT subtypes were examined in relation to psychosis symptoms measured by PANSS during one year of treatment with APs, by means of linear mixed effects (LME) models. Results were significant for CT subtypes, where increased levels of sexual abuse and physical neglect were associated with increased mean levels of psychosis symptoms throughout the course of treatment from baseline to 52 weeks. AP effectiveness may thus be influenced by CT subtype in SSDs. The results support clinical guidelines recommending a focus on assessment and treatment of trauma in SSDs.en_US
dc.identifier.citationMørkved, Johnsen, Kroken, Joa, Kjelby, Rettenbacher, Bartz-Johannessen, Løberg. Childhood trauma types in relation to antipsychotic effectiveness in schizophrenia spectrum disorders: A prospective, pragmatic, randomized controlled study. Psychiatry Research. 2024;341en_US
dc.identifier.cristinIDFRIDAID 2307647
dc.identifier.doi10.1016/j.psychres.2024.116169
dc.identifier.issn0165-1781
dc.identifier.issn1872-7123
dc.identifier.urihttps://hdl.handle.net/10037/35454
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalPsychiatry Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleChildhood trauma types in relation to antipsychotic effectiveness in schizophrenia spectrum disorders: A prospective, pragmatic, randomized controlled studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)