Now showing items 1-20 of 10438

    • Cereals and cereal products - a scoping review for nordic nutrition recommendations 2023 

      Skeie, Guri; Fadnes, Lars T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-14)
      Cereals and cereal products have traditionally been staple foods in many countries including in the Nordics and Baltics. Cereals can be consumed with their entire grain kernel and are then referred to as whole grains or can be consumed after removal of the bran or germ and are then referred to as refined grains. The terms cereals and grains are often used interchangeably. In this scoping review, ...
    • Lipidome Plasticity Enables Unusual Photosynthetic Flexibility in Arctic vs. Temperate Diatoms 

      Svenning, Jon Brage; Vasskog, Terje; Campbell, Karley Lynn; Bæverud, Agnethe Hansen; Myhre, Torbjørn Norberg; Dalheim, Lars; Forgereau, Zoé Lulu; Osanen, Janina Emilia; Hansen, Espen Holst; Bernstein, Hans Christopher (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-27)
      The diatom lipidome actively regulates photosynthesis and displays a high degree of plasticity in response to a light environment, either directly as structural modifications of thylakoid membranes and protein–pigment complexes, or indirectly via photoprotection mechanisms that dissipate excess light energy. This acclimation is crucial to maintaining primary production in marine systems, particularly ...
    • Liver sinusoidal cells eliminate blood-borne phage K1F 

      Romano, Javier Sánchez; Simon-Santamaria, Jaione; McCourt, Peter Anthony; Smedsrød, Bård Helge; Mortensen, Kim Erlend; Sagona, Antonia; Sørensen, Karen Kristine; Larsen, Anett Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-28)
      Phage treatment has regained attention due to an increase in multiresistant bacteria. For phage therapy to be successful, phages must reach their target bacteria in sufficiently high numbers. Blood-borne phages are believed to be captured by macrophages in the liver and spleen. Since liver sinusoids also consist of specialized scavenger liver sinusoidal endothelial cells (LSECs) and Kupffer ...
    • Developmental Perspectives on Transitions at Age 60: Individuals Navigating Across the Lifespan (TRAILS) – latest data collection in a longitudinal JYLS study 

      Kokko, Katja; Fadjukoff, Päivi; Reinilä, Emmi; Ahola, Johanna; Kinnunen, Marja-Liisa; Kroger, Jane; Laakkonen, Eija K.; Pitkänen, Tuuli; Pulkkinen, Lea; Staudinger, Ursula M.; Taipale, Sakari; Törmäkangas, Timo; Kekäläinen, Tiia; Saajanaho, Milla; Rantanen, Taina (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-24)
      At around age 60, people are approaching late adulthood and are typically going through or anticipating life transitions such as grandparenthood, retirement, or changes in health and functioning. The timing and perception of transitions are individual and based on current circumstances and earlier life history and may link to well-being. The TRAILS (Developmental Psychological Perspectives ...
    • Radiation-induced effects on TGF-β and PDGF receptor signaling in cancer-associated fibroblasts 

      Yang, Nannan; Hellevik, Turid; Berzaghi, Rodrigo; Martinez-Zubiaurre, Inigo (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-15)
      Background: Cancer-associated fibroblasts (CAFs) consist of heterogeneous connective tissue cells and are often constituting the most abundant cell type in the tumor stroma. Radiation effects on tumor stromal components like CAFs in the context of radiation treatment is not well-described.<p> <p>Aim: This study explores potential changes induced by ionizing radiation (IR) on platelet-derived ...
    • The Biofilm Lifestyle Shapes the Evolution of β-Lactamases 

      Lorentzen, Øyvind Myrvoll; Haukefer, Anne Sofie B.; Johnsen, Pål Jarle; Frøhlich, Christopher (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-15)
      The evolutionary relationship between the biofilm lifestyle and antibiotic resistance enzymes remains a subject of limited understanding. Here, we investigate how β-lactamases affect biofilm formation in Vibrio cholerae and how selection for a biofilm lifestyle impacts the evolution of these enzymes. Genetically diverse β-lactamases expressed in V. cholerae displayed a strong inhibitory effect on ...
    • Disruption of sleep by one night of in-home polysomnographic recording: a longitudinal actigraphy study of patients with chronic musculoskeletal pain and pain-free controls 

      Abeler, Karin Louise; Bergvik, Svein Hugo; Friborg, Oddgeir (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-25)
      Background Patients with chronic pain frequently have comorbid sleep disturbances. Since improvement of sleep may alleviate both sleep problems and to some extent pain, sleep studies in this group becomes relevant. Polysomnography (PSG) is considered the gold standard for characterizing sleep; however, it is resource-demanding and may itself disrupt sleep due to the use of inconvenient equipment in ...
    • “That Bastard Chose Me”: The Use of Metaphor in Women’s Cancer Blogs 

      Kvaale, Kaja; Synnes, Oddgeir Arne; Lian, Olaug Synnøve; Bondevik, Hilde (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-01)
      Metaphors play a significant role in how cancer is experienced and discussed. This study delves into the utilization of metaphors by women bloggers grappling with colorectal and gynecological cancers. By focusing on cancer types less represented in mainstream media, we aim to shed light on cancer cultures associated with body areas often considered taboo. Our findings reveal that widely recognized ...
    • Experiences with telemedicine-based follow-up of chronic conditions: the views of patients and health personnel enrolled in a pragmatic randomized controlled trial 

      Sten Gahmberg, Susanna; Pedersen, Kine; Harsheim, Ingrid Gaarder; Løyland, Hanna Isabel; Abelsen, Birgit (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-14)
      Background Telemedicine is often promoted as a possible solution to some of the challenges healthcare systems in many countries face, and an increasing number of studies evaluate the clinical effects. So far, the studies show varying results. Less attention has been paid to systemic factors, such as the context, implementation, and mechanisms of these interventions.<p> <p>Methods This study ...
    • Long-term cardiac effects of modern treatment for Hodgkin’s lymphoma 

      Bjerring, Anders W.; Smeland, Knut Bjøro; Stokke, Thomas Muri; Haugaa, Kristina Ingrid Helena Hermann; Holte, Espen; Rösner, Assami; Kiserud, Cecilie E.; Edvardsen, Thor; Sarvari, Sebastian (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-04)
      Background Hodgkin’s lymphoma (HL) is a hematological malignancy that affects both children and young adults. Traditional treatment is associated with a life-time prevalence of cardiac disease exceeding 50%. In the late 1990s protocols were modified to reduce cancer therapy-related adverse cardiac effects. This study aimed to assess the long-term impact of advances in treatment protocols on the ...
    • Quality, availability and suitability of antimicrobial stewardship guidance: a multinational qualitative study 

      Linde-Ozola, Zane; Classen, Annika Y.; Giske, Christian G.; Göpel, Siri; Eliakim-Raz, Noa; Semret, Makeda; Simonsen, Gunnar Skov; Vehreschild, Jörg Janne; Jørgensen, Silje Bakken; Kessel, Johanna; Kleppe, Lars Kåre Selland; Oma, Dorthea Hagen; Vehreschild, Maria J.G.T.; Vilde, Aija; Dumpis, Uga (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-14)
      Background: Antimicrobial stewardship (AMS) programmes are established across the world to treat infections efficiently, prioritize patient safety, and reduce the emergence of antimicrobial resistance. One of the core elements of AMS programmes is guidance to support and direct physicians in making efficient, safe and optimal decisions when prescribing antibiotics. To optimize and tailor AMS, we ...
    • Efficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial 

      Shang, Ya-xi; Wei, Shu-feng; Yang, Ke-peng; Liu, Yuan; Wei, Su; Dong, Xia; Wang, Xin-chang; Xie, Zhi-min; Fang, Ru-lu; Liang, Li-na; Li, Xiu-feng; Xu, Lei; Chen, Mu-zhi; Zhang, Kai-xian; Huang, Ji-yong; Wang, Le; Yang, You-guo; Liao, Hong-li; Xing, Gui-e; Zheng, Yu-ping; Li, Xiao-fen; Lin, Jing-lian; Shi, Cheng-qian; Zeng, Yong-ping; Mo, Li-dan; Sun, Fan; Li, Xiao-peng; Zhang, Zhuo; Chen, Kai; He, Zhao-chun; Liu, Jianping (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-04)
      Background This study aims to assess the efficacy and safety of Qingpeng ointment (QPO), a Tibetan medicine for alleviating symptoms in individuals with acute gouty arthritis (AGA).<p> <p>Methods This study was a randomized, double-blind, placebo-controlled trial that involved individuals with AGA whose joint pain, as measured on a visual analog scale (VAS) from 0 to 10, was equal to or greater ...
    • Quality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints series 

      Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Coats, Andrew J.S.; Dajani, Olav; Dolan, Ross D.; Fallon, Marie T.; Greil, Christine; Grzyb, Alexandra; Kaasa, Stein; Koteng, Lisa Heide; May, Anne M.; McDonald, James; Ottestad, Inger; Philips, Iain; Roeland, Eric J.; Sayers, Judith; Simpson, Melanie Rae; Skipworth, Richard J.E.; Solheim, Tora S; Sousa, Mariana S.; Vagnildhaug, Ola Magne; Laird, Barry J.A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-29)
      The use of patient-reported outcomes (PROMs) of quality of life (QOL) is common in cachexia trials. Patients' self-report on health, functioning, wellbeing, and perceptions of care, represent important measures of efficacy. This review describes the frequency, variety, and reporting of QOL endpoints used in cancer cachexia clinical trials. Electronic literature searches were performed in Medline, ...
    • Nordic diet and mortality: The Norwegian Women and Cancer study 

      Jensen, Torill (Doctoral thesis; Doktorgradsavhandling, 2024-10-10)
      <p><i>Background:</i> Noncommunicable diseases (NCDs) such as cancer and cardiovascular diseases (CVDs) are predominant causes of mortality in Norwegian women. With a national goal to reduce premature mortality from NCDs by 33% by 2030, Norway is also committed to achieving Sustainable Development Goals, including those related to climate change. The Food and Agriculture Organization (FAO) emphasizes ...
    • The role of lifestyle factors in the association between education and self-reported fibromyalgia: a mediation analysis 

      Benebo, Faith Owunari; Lukic, Marko; Jakobsen, Monika Dybdahl; Braaten, Tonje Bjørndal (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-17)
      Background Socioeconomic status as measured by education, income, or occupation, has been associated with fibromyalgia but the underlying mechanism and the role of lifestyle factors are unclear. Thus, we examine the role of modifiable lifestyle factors (body mass index, physical activity, alcohol consumption and smoking) in the association between education and self-reported fibromyalgia.<p> ...
    • Diverse methodological approaches to a Circumpolar multi-site case study which upholds and responds to local and Indigenous community research processes in the Arctic 

      Healey Akearok, Gwen K.; Chaliak, Ay’aqulluk Jim; Cueva, Katie; Cook, David; Larsen, Christina VL; Jóhannsdóttir, Lára; Nilsson, Lena Maria; San Sebastián, Miguel; Peterson, Malory; Timlin, Ulla; Broderstad, Ann Ragnhild; Dagsvold, Inger Johanne; Siri, Susanna Ragnhild Andersdatter; Olesen, Ingelise; Stoor, Jon Petter Anders; Rautio, Arja; Rink, Elizabeth; Lavoie, Josée G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-04)
      This paper outlines the methodological approaches to a multi-site Circumpolar case study exploring the impacts of COVID-19 on Indigenous and remote communities in 7 of 8 Arctic countries. Researchers involved with the project implemented a three-phase multi-site case study to assess the positive and negative societal outcomes associated with the COVID-19 pandemic in Arctic communities from ...
    • Using real world data for pharmacoeconomic assessments - a case study 

      Haukaas, Jeroen Martin van Zuiden (Mastergradsoppgave; Master thesis, 2024-05-14)
      Pembrolizumab monotherapy for non-small cell lung cancer (NSCLC) was deemed not cost-effective due to limited data, high uncertainty regarding long term results and a considerable budget impact. However, due to confidential price agreements it was approved in 2017, as first-line treatment for metastatic NSCLC that expresses PD-L1 ≥ 50 %. Given potential discrepancies between clinical efficacy and ...
    • Group-based mentoring in undergraduate medical education 

      Skjevik, Elise Pauline Paulsen (Doctoral thesis; Doktorgradsavhandling, 2024-09-27)
      This thesis focuses on group mentorship for undergraduate medical students as a pivotal element in fostering a supportive and collaborative learning environment, essential for the complex field of medicine. Previous studies have mostly focused on one-on-one mentoring. Group mentorships can foster a collaborative and reflective environment in which students can benefit from the collective knowledge ...
    • Comprehensive virulence profiling and evolutionary analysis of specificity determinants in Staphylococcus aureus two-component systems 

      Ahator, Stephen Dela; Wenzl, Karoline; Hegstad, Kristin; Lentz, Christian Stephan; Johannessen, Mona Susan (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-12)
      n the Staphylococcus aureus genome, a set of highly conserved two-component systems (TCSs) composed of histidine kinases (HKs) and their cognate response regulators (RRs) sense and respond to environmental stimuli, which drive the adaptation of the bacteria. This study investigates the complex interplay between TCSs in S. aureus USA300, a predominant methicillin-resistant S. aureus strain, revealing ...
    • Self-reported exposure to dust and diesel exhaust, respiratory symptoms, and use of respiratory protective equipment among Arctic miners 

      Peyre Costa, David; Stjernbrandt, Albin; Wahlström, Jens; Ikäheimo, Tiina Maria Anneli; Höper, Anje Christina (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-16)
      Arctic miners face significant risks from diesel exhaust and dust exposure, potentially leading to adverse respiratory health. Employers must limit harmful exposures, using personal protective equipment (PPE) as a last line of defense. This study explored the association between reported respiratory exposure and symptoms, and PPE training and usage. Data from the MineHealth study (2012–2014) ...