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norskDet helsevitenskapelige fakultet: Recent submissions
Now showing items 1701-1720 of 10439
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The severe impact of the COVID-19 pandemic on bullying victimization, mental health indicators and quality of life
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-31)Children and adolescents have been severely affected by the COVID-19 pandemic. The aim of this study was to explore the prevalence of traditional and digital bullying and mental health problems a year into the pandemic. Further, how anxiety level, loneliness, and self-perceived school functioning have influenced the quality of life. A comprehensive questionnaire was administered (N = 1239) in the ... -
Experiences and management strategies of Norwegian GPs during the COVID-19 pandemic: a longitudinal interview study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-09)Objective: When the COVID-19 pandemic reached Norway, primary health care had to reorganize to ensure safe patient treatment and maintain infection control. General practitioners (GPs) are key health care providers in the municipalities. Our aim was to explore the experiences and management strategies of Norwegian GPs during the COVID-19 pandemic - over time, and in the context of a sudden ... -
The severe impact of the COVID-19 pandemic on bullying victimization, mental health indicators and quality of life
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-31)Children and adolescents have been severely affected by the COVID-19 pandemic. The aim of this study was to explore the prevalence of traditional and digital bullying and mental health problems a year into the pandemic. Further, how anxiety level, loneliness, and self-perceived school functioning have influenced the quality of life. A comprehensive questionnaire was administered (N = 1239) in the ... -
Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-16)Background: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses.<p> <p>Methods: The observational analyses included 286,415 ... -
Ten-year tenure as a physician CEO at a Nordic university hospital: Five lessons learnt
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-21)Background - I was a 42-year-old neurosurgeon with experience as department head when I took chair as chief executive officer (CEO) at the University Hospital of North Norway to lead a comprehensive organisational and financial restructuring. This article aims to develop lessons learnt during my 10-year tenure.<p> <p>Methods - I restructured the organisation and hired a new executive team. We ... -
Corrigendum to “Clinical reasoning in traditional medicine exemplified by the clinical encounter of Korean medicine” [Integr Med Res 2021: 10; 100641]
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-22)The authors regret that the funding number was incorrectly published in the above article. It is now reproduced correctly below. The authors would like to apologize for any inconvenience caused. -
Kjønnsstratifiserte analyser i norske behandlingsstudier: en systematisk kartleggingsoversikt
(Research report; Forskningsrapport, 2022)Biologisk kjønn har betydning for kliniske utfall, og kunnskap om kjønnsforskjeller i behandlingsutfall kan bidra til sikrere og mer tilpasset behandling for pasienter. Hensikten med denne kartleggingsoversikten var å undersøke bruken av kjønnsstratifiserte analyser i studier på effekt av behandling i en norsk sammenheng.<p> <p>Vi utførte en kartleggingsoversikt. Det er en type kunnskapsoppsummering ... -
Nasjonale og regionale melde- og varselordninger for uønskede hendelser i pasientbehandlingen: systematisk oversikt
(Research report; Forskningsrapport, 2022)Alle virksomheter som yter helse- og omsorgstjenester skal arbeide systematisk for å redusere risiko for pasientskade som følge av tjenesteytelsen eller mangel på ytelse. Likevel oppstår uønskede hendelser av varierende alvorlighetsgrad. Anslagsvis rammer uønskede hendelser én av ti pasienter i norske sykehus. Norske virksomheter som yter helse- og omsorgstjenester plikter å varsle om alvorlige ... -
Utvalgt forskning om melde- og varselordninger i helse- og omsorgstje-nesten: forenklet metodevurdering – kartlegging
(Research report; Forskningsrapport, 2022-10)En nylig utført systematisk oversikt viste at det ikke finnes forskning som har undersøkt effekten av nasjonale og regionale, generelle melde- og varselordninger på alvorlige hendelser i helse- og omsorgstjenesten. Derfor var det hensiktsmessig å undersøke forskning som har sett på tilgrensende problemstillinger.<p> <p>Formålet med dette arbeidet var å kartlegge studier om mulige sammenhenger ... -
Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-22)Importance Identification of proteins and genetic factors that reduce Alzheimer disease (AD) pathology is of importance when searching for novel AD treatments. Heterozygosity of the KL-VS haplotype has been associated with reduced amyloid and tau burden. Whether this association is mediated by the Klotho protein remains unclear. Objectives To assess concentrations of Klotho in cerebrospinal ... -
Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-04)Background: Tobacco exposure causes 8 of 10 lung cancers, and identifying additional risk factors is challenging due to confounding introduced by smoking in traditional observational studies.<p> <p>Materials and Methods: We used Mendelian randomization (MR) to screen 207 metabolites for their role in lung cancer predisposition using independent genome-wide association studies (GWAS) of blood ... -
Sex differences in arterial hypertension
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-22)There is strong evidence that sex chromosomes and sex hormones influence blood pressure (BP) regulation, distribution of cardiovascular (CV) risk factors and co-morbidities differentially in females and males with essential arterial hypertension. The risk for CV disease increases at a lower BP level in females than in males, suggesting that sex-specific thresholds for diagnosis of hypertension may ... -
Towards interprofessional patient care: Health profession students exploring interprofessional collaboration in group meetings in joint clinical placement
(Doctoral thesis; Doktorgradsavhandling, 2023-01-20)The aim of this study is to develop knowledge about how health profession students learn interprofessional collaboration in group meetings during a joint voluntary period of practice. It is an observational study. Interprofessional student groups were followed throughout a two-week practice period. The groups had a mandate to independently develop interprofessional collaboration in the healthcare ... -
The seventh survey of the Tromsø Study (Tromsø7) 2015–2016: study design, data collection, attendance, and prevalence of risk factors and disease in a multipurpose population-based health survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-04)Aims: The Tromsø Study is an ongoing population-based health study in Tromsø, Norway, initiated in 1974. The purpose of the seventh survey (Tromsø7) 2015–2016 was to advance the population risk factor surveillance and to collect new types of data. We present the study design, data collection, attendance, and prevalence of risk factors and disease. Methods: All inhabitants in Tromsø municipality, ... -
Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-12)Background: Rhabdomyosarcoma (RMS) is a paediatric cancer driven either by fusion proteins (e.g., PAX3-FOXO1) or by mutations in key signalling molecules (e.g., RAS or FGFR4). Despite the latter providing opportunities for precision medicine approaches in RMS, there are currently no such treatments implemented in the clinic.<p> <p>Methods: We evaluated biologic properties and targeting strategies ... -
A study of occupational health among mine workers in Murmansk Oblast, Russia
(Doctoral thesis; Doktorgradsavhandling, 2014-05-27)The mining industry is growing in the north, with the largest mining communities located in North Russia. Increased knowledge about the health and work conditions of the employees is important in order to enhance safety and prevention of ill health. The aim of the study was to describe how the health of mine workers in Murmansk oblast is assessed, determine the prevalence of low back pain (LBP) as ... -
Hjertepasienters opplevelse av fysisk aktivitet og trening: En kvalitativ metasyntese
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-27)Bakgrunn: Treningsbasert hjerterehabilitering kan øke livskvalitet, bedre arbeidskapasitet og redusere risikofaktorer for reinnleggelse og kardiovaskulær død. Likevel klarer mange pasienter ikke fortsette med trening etter et rehabiliteringsopphold, og kun halvparten klarer å opprettholde det anbefalte nivået for fysisk aktivitet. Derfor er det viktig å undersøke hvilke erfaringer pasientene har med ... -
SLE classification criteria: Science-based icons or algorithmic distractions – an intellectually demanding dilemma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-28)It is, so to say, not a prerogative authority assigned to SLE classification criteria that allow them to declare something definitively important about SLE. This is particularly true as criteria-based classification processes overrule the highly needed evolution of concise diagnostic criteria. It is classification criteria that allocate SLE patients into cohorts intended to describe the nature of ... -
Discovering the structure and organization of a free Cantonese emotion-label word association graph to understand mental lexicons of emotions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-15)Emotions are not necessarily universal across different languages and cultures. Mental lexicons of emotions depend strongly on contextual factors, such as language and culture. The Chinese language has unique linguistic properties that are different from other languages. As a main variant of Chinese, Cantonese has some emotional expressions that are only used by Cantonese speakers. Previous work on ... -
Comparative analysis of Vibrio cholerae isolates from Ghana reveals variations in genome architecture and adaptation of outbreak and environmental strains
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-13)Recurrent epidemics of cholera denote robust adaptive mechanisms of Vibrio cholerae for ecological shifting and persistence despite variable stress conditions. Tracking the evolution of pathobiological traits requires comparative genomic studies of isolates from endemic areas. Here, we investigated the genetic differentiation among V. cholerae clinical and environmental isolates by highlighting the ...
