Det helsevitenskapelige fakultet: Recent submissions

Now showing items 1821-1840 of 10439

    • Adherence and persistence to pharmacotherapy in patients with heart failure: a nationwide cohort study, 2014–2020 

      Ødegaard, Kristina Malene; Lirhus, Sandre Svatun; Melberg, Hans Olav; Hallen, Jonas; Halvorsen, Sigrun (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-20)
      Aims - We aimed to study initiation, adherence, and long-term persistence to beta-blockers (BB), renin–angiotensin system inhibitors (RASi), and mineralocorticoid receptor antagonists (MRA) in a nationwide cohort of patients with heart failure (HF).<p> <p>Methods - Patients aged 18–80 years in Norway with a first diagnosis of HF from 2014 until 2020 that survived ≥30 days were identified from the ...

    • Transitioning patients with juvenile idiopathic arthritis to adult care: the Nordic experience 

      Mikola, Katriina; Rebane, Katariina; Arnstad, Ellen Dalen; Berntson, Lillemor; Fasth, Anders; Glerup, Mia; Herlin, Troels; Kautiainen, Hannu; Nielsen, Susan; Nordal, Ellen Berit; Peltoniemi, Suvi; Rygg, Marite; Rypdal, Veronika; Zak, Marek; Aalto, Kristiina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-01)
      Background: With juvenile idiopathic arthritis (JIA), there are several protocols and practices used worldwide for the transition from paediatric to adult care. In this study, we examined the transferral rates and disease activity after transition, as well as the disease- and health-related outcomes. We also introduce the transition practices employed in the Nordic countries.<p> <p>Methods: The ...

    • Early surfactant and non-invasive ventilation versus intubation and surfactant: a propensity score-matched national study 

      Reigstad, Hallvard; Hufthammer, Karl Ove; Rønnestad, Arild Erland; Klingenberg, Claus Andreas; Stensvold, Hans Jørgen; Markestad, Trond Jacob (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-27)
      <p><b> Objective</b> To compare outcome after less invasive surfactant administration (LISA) and primary endotracheal intubation (non-LISA) in infants born before gestational age (GA) 28 weeks. <p><b> Setting</b> All neonatal intensive care units (NICUs) in Norway during 2012–2018. <p><b> Methods</b> Defined population-based data were prospectively entered into a national registry. We ...

    • Active commuting and work ability: A cross-sectional study of chicken meat industry workers in Thailand 

      Phanprasit, Wantanee; Chotiphan, Chotirot; Konthonbut, Pajaree; Laohaudomchok, Wisanti; Ikäheimo, Tiina; Jaakkola, Jouni J.K.; Näyhä, Simo (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-11)
      There is ample evidence regarding positive health effects of cycling or walking to work (active commuting [AC]). However, little is known about the effects of AC on work ability. Therefore, we examined 422 Thai chicken meat industry workers who assessed their current work ability (CWA) compared to their lifetime best by assigning scores ranging from 0 to 10. The CWA was compared between active ...

    • Using storytelling in undergraduate dental education: Students' experiences of emotional competence training 

      Johnsen, Jan-Are Kolset; Borit, Melania; Stangvaltaite-Mouhat, Lina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-03)
      Aim: The aim of the study was to explore the use of storytelling as a teaching method for emotional competence interventions within undergraduate dental curriculum (dental and dental hygiene students).<p> <p>Materials and Methods: Students participated in five sessions related to emotional competence: one theoretical and four practical. During the latter, divided in small groups, students told ...

    • Lokalbehandling av utbrudd ved Hidrosadenitt 

      Lien, Ludvik Hovda (Master thesis; Mastergradsoppgave, 2020-11-13)
      <p>Bakgrunn: Hidrosadenitt (HS) er en kronisk inflammatorisk hudsykdom som kjennetegnes av et svingende forløp med hyppige residiv av smertefulle lesjoner. Tilstanden er en klinisk utfordring, spesielt da informasjon om best tilgjengelig behandling av disse utbruddene er vanskelig tilgjengelig for klinikere. Formålet med oppgaven er å undersøke dokumentasjonen bak disse behandlingsformene, også med ...

    • Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells 

      Vilaplana-Lopera, Nuria; Cuminetti, Vincent; Almaghrabi, Ruba; Papatzikas, Grigorios; Rout, Ashok Kumar; Jeeves, Mark; González, Elena; Alyahyawi, Yara; Cunningham, Alan; Erdem, Ayşegül; Schnütgen, Frank; Raghavan, Manoj; Potluri, Sandeep; Cazier, Jean-Baptiste; Schuringa, Jan Jacob; Reed, Michelle AC; Arranz, Lorena; Günther, Ulrich L; Garcia, Paloma (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-02)
      Acute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been shown to support AML survival and progression through various mechanisms. Nonetheless, whether AML cells could establish beneficial metabolic interactions with stromal cells is underexplored. By using a combination of human AML cell lines and AML ...

    • ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform 

      Klec, Christiane; Knutsen, Erik; Schwarzenbacher, Daniela; Jonas, Katharina; Pasculli, Barbara; Heitzer, Ellen; Rinner, Beate; Krajina, Katarina; Prinz, Felix; Gottschalk, Benjamin; Ulz, Peter; Deutsch, Alexander; Prokesch, Andreas; Jahn, Stephan W.; Lellahi, Seyed Mohammad; Perander, Maria; Barbano, Raffaela; Graier, Wolfgang F.; Parrella, Paola; Calin, George Adrian; Pichler, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-01)
      The RNA-binding protein ALYREF (THOC4) is involved in transcriptional regulation and nuclear mRNA export, though its role and molecular mode of action in breast carcinogenesis are completely unknown. Here, we identifed high ALYREF expression as a factor for poor survival in breast cancer patients. ALYREF signifcantly infuenced cellular growth, apoptosis and mitochondrial energy metabolism in ...

    • Total Oxidizable Precursors Assay for PFAS in Human Serum 

      Cioni, Lara; Nikiforov, Vladimir; Miranda Fernandes Coelho, Ana Carolina; Sandanger, Torkjel M; Herzke, Dorte (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-23)
      Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals including over 4700 substances. As a limited number of PFAS is routinely analyzed in human serum, complementary analytical methods are required to characterize the overlooked fraction. A promising tool is the total oxidizable precursors (TOP) assay to look for precursors by oxidation to perfluoroalkyl acids (PFAA). The TOP assay was ...

    • Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study 

      Fortuin-de Smidt, Melony C.; Sewe, Maquins Odhiambo; Lassale, Camille; Weiderpass, Elisabete; Andersson, Jonas; Huerta, José María; Ekelund, Ulf; Aleksandrova, Krasimira; Tong, Tammy Yn; Dahm, Christina C.; Tjønneland, Anne; Kyrø, Cecilie; Steindorf, Karen; Schulze, Matthias B.; Katzke, Verena; Sacerdote, Carlotta; Agnoli, Claudia; Masala, Giovanna; Tumino, Rosario; Panico, Salvatore; Boer, Jolanda Ma; Onland-Moret, N Charlotte; Wendel-Vos, Gc Wanda; van der Schouw, Yvonne T.; Borch, Kristin Benjaminsen; Agudo, Antonio; Petrova, Dafina; Chirlaque, María Dolores; Conchi, Moreno Iribas; Amiano, Pilar; Melander, Olle; Heath, Alicia K.; Aune, Dagfinn; Forouhi, Nita G.; Langenberg, Claudia; Brage, Soren; Riboli, Elio; Wareham, Nicholas J.; Danesh, John; Butterworth, Adam S.; Wennberg, Patrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-11)

    • Two-year motor outcomes associated with the dose of NICU based physical therapy: The Noppi RCT 

      Øberg, Gunn Kristin; Handegård, Bjørn Helge; Campbell, Suzann K.; Ustad, Tordis; Fjørtoft, Toril Larsson; Kaaresen, Per Ivar; Girolami, Gay L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-25)
      Background - Interventions involving both the parent and the preterm infant have demonstrated lasting effects on cognitive outcomes, but motor effects are less salient. It remains unclear when to commence early intervention and if dosages have impact on motor outcomes.<p> <p>Aims - To examine the effect on motor performance at 24-months corrected age following a parent-administered intervention ...

    • A four-month home-based tDCS study on patients with Alzheimer’s disease 

      Grønli, Ole Kristian; Rasmussen, Ingrid Daae; Aslaksen, Per M; Bystad, Martin Kragnes (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-19)
      In the present open-label study, our first aim was to study the tolerability and feasibility of long-term treatment with transcranial direct current stimulation (tDCS) and the second aim was to measure whether the treatment led to cognitive improvement. Participants with AD used a tDCS home-treatment kit inducing a low current (2 mA) via two scalp electrodes 30 minutes daily for 4 months. A total ...

    • Reduction in manual asymmetry and decline in fine manual dexterity in right-handed older adults with mild cognitive impairment 

      Vasylenko, Olena; Gorecka, Marta Maria; Waterloo, Knut; Rodríguez-Aranda, Claudia (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-16)
      Research in Parkinson’s or Alzheimer’s disease suggests that hand function is affected by neurodegenerative diseases. However, little is known about the relationship between hand function and mild cognitive impairment (MCI). Therefore, we conducted a kinematic analysis of unimanual hand movements in MCI patients to answer whether manual asymmetries and manual dexterity are affected or preserved ...

    • Cervical spine surgery in the Northern Norway Regional Health Authority area in 2014-18 

      Ingebrigtsen, Tor; Guldhaugen, Kristel Ailin; Kristiansen, Jon-André; Kloster, Roar; Grotle, Margreth; Solberg, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-24)
      <p>BAKGRUNN - Kunnskap om variasjon i behandlingsrater er nødvendig for å vurdere om tilgangen til helsetjenester er likeverdig. Formålet med denne studien var å undersøke rater for kirurgisk behandling av degenerative nakkelidelser i Norge og Helse Nord, samt egendekningen i Helse Nord, og å vurdere aktiviteten i regionen. <p>MATERIALE OG METODE - Vi inkluderte operasjoner registrert i Norsk ...

    • The effect of transcranial direct current stimulation on the interplay between executive control, behavioral variability and mind wandering: A registered report 

      Alexandersen, Andreas; Mittner, Matthias; Csifcsak, Gabor; Groot, Josephine Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-11)
      Mind wandering (MW) is a mental phenomenon humans experience daily. Yet, we lack a complete understanding of the neural basis of this pervasive mental state. Over the past decade there has been an increase in publications using transcranial direct current stimulation (tDCS) to modulate the propensity to mind wander, but findings are diverse, and a satisfactory conclusion is missing. Recently, Boayue ...

    • Health professionals' experience of treatment of patients whose community treatment order was revoked under new capacity-based mental health legislation in Norway: qualitative study 

      Wergeland, Nina Camilla; Fause, Åshild; Fause, Anett Beatrix Osnes; Riley, Henriette; Weber, Astrid Karine (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-11)
      <p><b> Background</b> Norway introduced capacity-based legislation in mental healthcare on 1 September 2017 with the aim of increasing patient autonomy and legal protection and reducing the use of coercion. The new legislation was expected to be particularly important for patients under community treatment orders (CTOs). <p><b> Aims</b> To explore health professionals’ experiences of how ...

    • Healthcare Professionals' Experiences with Rehabilitation Practices for Patients with Cognitive Impairment after Stroke in North Norway: A Qualitative Study 

      Bogstrand, Anniken; Gramstad, Astrid; Anke, Audny Gabriele Wagner; Stabel, Henriette Holm; Arntzen, Cathrine (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-12)
      <i>Background and Aim.</i> Cognitive impairment is a common consequence following stroke. Previous research shows differences in rehabilitation services supporting physical, cognitive, and psychosocial needs. The aim of the current study was to explore health professionals’ experiences with service provision for patients with mild and moderate cognitive impairment after stroke in a North Norwegian ...

    • Possible strategies for use of artificial intelligence in screen-reading of mammograms, based on retrospective data from 122,969 screening examinations 

      Larsen, Marthe; Aglen, Camilla Flåt; Hoff, Solveig Roth; Lund-Hanssen, Håkon; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-15)
      Objectives Artificial intelligence (AI) has shown promising results when used on retrospective data from mammographic screening. However, few studies have explored the possible consequences of different strategies for combining AI and radiologists in screen-reading.<p> <p>Methods A total of 122,969 digital screening examinations performed between 2009 and 2018 in BreastScreen Norway were retrospectively ...

    • A novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hip 

      Tanturri De Horatio, Laura; Shelmerdine, Susan C.; d’Angelo, Paola; Di Paolo, Pier Luigi; Magni-Manzoni, Silvia; Malattia, Clara; Damasio, Maria Beatrice; Tomà, Paolo; Avenarius, Derk Frederik Matthaus; Rosendahl, Karen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-23)
      Abstract Background Hip involvement predicts severe disease in juvenile idiopathic arthritis (JIA) and is accurately assessed by MRI. However, a child-specifc hip MRI scoring system has not been validated.<p> <p>Objective To test the intra- and interobserver agreement of several MRI markers for active and chronic hip changes in children and young adults with JIA and to examine the precision of ...

    • Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains 

      Sørum, Vidar; Øynes, Emma Lu; Sollied Møller, Anna; Harms, Klaus; Samuelsen, Ørjan; Podnecky, Nicole L.; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-07)
      ABSTRACT Collateral sensitivity and resistance occur when resistance development toward one antimicrobial either potentiates or deteriorates the effect of others. Previous reports on collateral effects on susceptibility focus on newly acquired resistance determinants and propose that novel treatment guidelines informed by collateral networks may reduce the evolution, selection, and spread of ...