Many of the anticancer compounds discovered through synthesis or bioprospecting activities are found to be equally toxic to healthy cells and tumors. Consequently, these compounds are not considered as promising drug candidates worthy of further study. This project seeks to develop a novel chemical toolkit that can be utilized to increase the therapeutic value of such toxic compounds by decreasing ...

Helse- og sosialarbeidere, i private og offentlige arbeids- og velferdstjenester, har daglig kontakt med mennesker som har traumeerfaringer og sammensatte behov. Kommunikasjonen kan være følelsesmessig utfordrende og mange fagpersoner opplever dårlig tid, utrygghet og stress i arbeidet. Utrygghet og stress øker konfliktnivået og har en negativ effekt på fagpersoners velvære, holdninger til tjenestebrukere ...

The rapid increase in antibiotic resistance is one of the leading global health issues at present time. Bacteria’s resistance to antibiotic agents can be a thousand times higher when they are embedded in an extracellular biopolymer matrix, defined as biofilm. The biofilm state is a major driver of persistent infections, offering a challenge in providing adequate treatment. Biofilm producing E. coli ...

Ischemic injury worsens upon return of blood and innate immunity including the complement system play a central role in ischemia-reperfusion injury (IRI) as in thoracic aortic surgery. Complement component1 inhibitor (C1-INH) has been shown to reduce IRI and is a broad-acting plasma cascade inhibitor. We established a new porcine model of IRI by cross-clamping the thoracic aorta and evaluated the ...

In 2006, VKM published “A comprehensive assessment of fish and other seafood in the Norwegian diet”. The assessment supported the recommendation from Norwegian Health authorities to eat more fish both for dinner and on sandwiches. In an update of the assessment in 2014 VKM concluded that “the benefits from fish consumption clearly outweigh the negligible risk presented by current levels of ...

Large-scale electronic health record (EHR) suites are expected to cover a broad range of use scenarios for healthcare workers in hospitals, nursing homes, home-care services, and general practitioner (GP) clinics. However, preparation for the implementation of EHR suites requires years of detailed planning and consumes considerable financial and human resources. A key problem, then, is that there ...

<p><i>Introduction - </i>Riociguat is a soluble guanylate cyclase stimulator approved for the treatment of pulmonary hypertension. Its effect on cardiometabolic efficiency is unknown. A potential cardiac energy sparing effect of this drug could imply a positive prognostic effect, particularly in patients with right heart failure from pulmonary hypertension. <p><i>Method - </i>We infused Riociguat ...

Why do students leave universities? The current study addresses the problem of academic attrition from the perspective of students’ intentions. Specifically, we focus on the roles of academic self-efficacy and procrastination in exploring their relationships with attrition intentions. Based on existing research, we expected a negative relationship between academic self-efficacy and attrition ...

Background: Venous thromboembolism (VTE) is associated with increased risk of disability pension. How socioeconomic status (SES) impacts the risk of disability pension after a VTE is unknown. The aim of this nationwide population based cohort study to investigate the interaction between SES and incident VTE on the risk of subsequent disability pension.<p> <p>Methods: Using Danish national medical ...

<p>Despite immense progress in the prevention, diagnosis and treatment of coronary heart disease, several challenges remain. In more than half of patients referred to coronary angiography for stable and unstable angina, no obstructive coronary artery disease (CAD) is found. At the same time, some patients present for the first time with already extensive CAD. Further, the management of unstable ...