Det helsevitenskapelige fakultet: Recent submissions

Now showing items 2861-2880 of 10466

    • ” Being mutually involved in recovery”. A hermeneutic exploration of nurses’ experiences of patient participation in psychiatric care 

      Wiklund Gustin, Lena (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-26)
      Purpose: This study aims at exploring how psychiatric nurses’ experiences of patient participation could be understood from a caring science perspective.<p> Methods: The design was inspired by clinical application research., which is a hermeneutic approach developed within caring science research. . In this study data were co-created during four reflective group dialogues where five participants’ ...

    • Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study 

      Reyes, Luis Felipe; Murthy, Srinivas; Garcia-Gallo, Esteban; Irvine, Mike; Merson, Laura; Martin-Loeches, Ignacio; Rello, Jordi; Taccone, Fabio S.; Fowler, Robert A.; Docherty, Annemarie B.; Kartsonaki, Christiana; Aragao, Irene; Barrett, Peter W.; Beane, Abigail; Burrell, Aidan J.C.; Cheng, Matthew Pellan; Christian, Michael D.; Cidade, Jose Pedro; Citarella, Barbara Wanjiru; Donnelly, Christl A.; Fernandes, Susana M.; French, Craig; Haniffa, Rashan; Harrison, Ewen M.; Ho, Antonia Ying Wai; Joseph, Mark; Khan, Irfan Ahmad; Kho, Michelle E.; Kildal, Anders Benjamin; Kutsogiannis, Demetrios; Lamontagne, François; Lee, Todd C.; Bassi, Gianluigi Li; Revilla, Jose Wagner Lopez; Marquis, Catherine; Millar, Jonathan; Neto, Raul; Nichol, Alistair; Parke, Rachael; Pereira, Rui; Poli, Sergio; Povoa, Pedro; Ramanathan, Kollengode; Rewa, Oleksa; Riera, Jordi; Shrapnel, Sally; Silva, Maria Joao; Udy, Andrew; Uyeki, Timothy; Webb, Steve A.; Wils, Evert-Jan; Rojek, Amanda; Olliaro, Piero L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-14)
      Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained in critical care. The clinical characteristics and the relative impact of caring for severe COVID-19 patients outside the ICU is unknown. This was a multinational, multicentre, ...

    • Dopamine-related receptors, substance dependence, behavioral problems and personality among juvenile delinquents 

      Ruchkin, Vladislav; Koposov, Roman A; Oreland, Lars; af Klinteberg, Britt; Grigorenko, Elena L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)
      The objective was two-fold: to examine possible associations between dopamine-related genetic polymorphisms and (1) substance dependence; and (2) self-reported psychiatric disturbances, behavioral problems, and personality. Genotyping of single nucleotide polymorphisms (SNP: s) in COMT, DAT and DRD4 was conducted in 174 Russian male juvenile inmates (14–18 years of age) subdivided into having a ...

    • Integrating the clinical pharmacist into the emergency department interdisciplinary team: A study protocol for a multicentre trial applying a non-randomised stepped-wedge study design 

      Vesela, Renata; Elenjord, Renate; Lehnbom, Elin; Ofstad, Eirik Hugaas; Johnsgård, Tine; Zahl-Holmstad, Birgitte; Risør, Torsten; Wisløff, Torbjørn; Røslie, Lars; Filseth, Ole Magnus; Valle, Per Christian; Svendsen, Kristian; Frøyshov, Hanne Mathilde; Garcia, Beate Hennie (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
      Introduction: The ‘emergency department (ED) pharmacist’ is an integrated part of the ED interdisciplinary team in many countries, which have shown to improve medication safety and reduce costs related to hospitalisations. In Norway, few EDs are equipped with ED pharmacists, and research describing effects on patients has not been conducted. The aim of this study is to investigate the impact ...

    • What are we optimizing for in autism screening? Examination of algorithmic changes in the M‐CHAT 

      Schjølberg, Synnve; Shic, Frederick; Volkmar, Fred R.; Nordahl-Hansen, Anders; Stenberg, Nina; Torske, Tonje; Larsen, Kenneth; Riley, Katherine; Sukhodolsky, Denis G.; Leckman, James F.; Chawarska, Katarzyna; Øien, Roald A (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-26)
      The present study objectives were to examine the performance of the new M-CHAT-R algorithm to the original M-CHAT algorithm. The main purpose was to examine if the algorithmic changes increase identification of children later diagnosed with ASD, and to examine if there is a trade-off when changing algorithms. We included 54,463 screened cases from the Norwegian Mother and Child Cohort Study. ...

    • Support and resources to promote and sustain health among nurses and midwives in the workplace: A qualitative study 

      Thapa, Dip Raj; Ekström-Bergström, Anette; Krettek, Alexandra; Areskoug Josefsson, Kristina (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-09)
      Registered nurses and midwives are in short supply and have among the highest rates of sick leave in the global workforce. The aim of this study was therefore to explore and gain a deeper understanding of how nurses and midwives experience their everyday work, with a view toward promoting and sustaining their work-related health. Nine registered nurses and four registered midwives working in hospitals ...

    • Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations 

      Flatby, Helene Marie; Rasheed, Humaira; Ravi, Anuradha; Thomas, Laurent; Liyanarachi, Kristin Vardheim; Afset, Jan Egil; DeWan, Andrew; Brumpton, Ben Michael; Hveem, Kristian; Åsvold, Bjørn Olav; Simonsen, Gunnar Skov; Furberg, Anne-Sofie; Damås, Jan Kristian; Solligård, Erik; Rogne, Tormod (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-09)
      Objective: Lower respiratory tract infections (LRTIs) are a leading cause of morbidity and mortality worldwide. Few studies have previously investigated the genetic susceptibility and potential risk factors for LRTI. Methods: We used data from UK Biobank, HUNT, and FinnGen, to conduct a genome-wide association study (GWAS). Cases were subjects hospitalized with LRTI, and controls were subjects with ...

    • Måleegenskaper ved den norske versjonen av Marschak Interaction method (MIM) 

      Rye, Marte; Drozd, Filip (Journal article; Tidsskriftartikkel; Peer reviewed, 2021)
      Beskrivelse. Marschak Interaction Method (MIM) er en observasjonsmetode utviklet for å undersøke og vurdere samspillet mellom barn og omsorgsgiver. MIM ble utviklet av Marianne Marschak (1960) og senere tilpasset til bruk sammen med intervensjonen Theraplay. Rettighetshaver for MIM er the Theraplay Institute. MIM består av ulike oppgaver som omsorgsgiver og barnet utfører sammen. Oppgavene er utformet ...

    • Phenotypic Characteristics and Melanoma Thickness in Women. 

      Ghiasvand, Reza; Green, Adele C.; Sandanger, Torkjel M; Weiderpass, Elisabete; Robsahm, Trude Eid; Veierød, Marit Bragelien (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-21)
      Patients’ phenotypic characteristics might be associated with melanoma aggressiveness, but the evidence is scarce. This study examined the associations be­tween pigmentary characteristics, naevi and melanoma thickness. Data from the Norwegian Women and Cancer (NOWAC) study were analysed. By 2014, 1,243 women were diagnosed with a primary melanoma, and 1,140 had information on thickness. Using ordinal ...

    • Cumulative risk of a false-positive screening result: A retrospective cohort study using empirical data from 10 biennial screening rounds in BreastScreen Norway 

      Tsuruda, Kaitlyn; Larsen, Marthe; Roman, Marta; Hofvind, Solveig (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-21)
      <p><b>Background</b> False-positive screening results are an inevitable and commonly recognized disadvantage of mammographic screening. This study estimated the cumulative probability of experiencing a first false-positive screening result in women attending 10 biennial screening rounds in BreastScreen Norway, which targets women aged 50 to 69 years. <p><b>Methods</b> This retrospective ...

    • Strategies for Prevention and Treatment of COVID-19 related Symptoms. A Population Based Cross-sectional Study in Norway, Sweden and the Netherlands 

      Kristoffersen, Agnete Egilsdatter; Esther T., van der Werf; Stub, Trine; Musial, Frauke; Wider, Barbara; Jong, Miek; Danell, Jenny-Ann B.; Busch, Martine; Hoenders, H. J. Rogier; Nordberg, Johanna H.; Wode, Kathrin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-23)
      Objectives: The present study was initiated to determine consultations with health care providers and use of selfmanagement strategies for prevention or treatment of COVID-19 related symptoms in countries with a full lockdown (Norway), a partial lockdown (the Netherlands) and no lockdown (Sweden) during the first three months of the COVID-19 pandemic, and if such use correlates with worries of being ...

    • PSMA Expression in Differentiated Thyroid Cancer: Association with Radioiodine, 18FDG Uptake, and Patient Outcome 

      Ciappuccini, Renaud; Saguet-Rysanek, Virginie; Giffard, Florence; Licaj, Idlir; Dorbeau, Marine; Clarisse, Bénédicte; Poulain, Laurent; Bardet, Stéphane (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-31)
      Context: Little is known about prostate-specific membrane antigen (PSMA) expression in patients with cervical involvement of differentiated thyroid cancer (DTC).<p> Objective: We investigated PSMA expression in neck persistent/recurrent disease (PRD) using immunohistochemistry and the association with radioiodine (RAI) or 18-fluorodeoxyglucose (<sup>18</sup>FDG) uptake, and patient outcome.<p> Design, ...

    • Evaluation of protein and amino acid intake estimates from the EPIC dietary questionnaires and 24-h dietary recalls using different food composition databases 

      Iguacel, Isabel; Perez-Cornago, Aurora; Schmidt, Julie A.; Van Puyvelde, Heleen; Travis, Ruth; Casagrande, Corinne; Nicolas, Genevieve; Riboli, Elio; Weiderpass, Elisabete; Ardanaz, Eva; Barricarte, Aurelio; Bodén, Stina; Bruno, Eleonora; Ching-López, Ana; Aune, Dagfinn; Jensen, Torill; Ericson, Ulrika; Johansson, Ingergerd; Ma Huerta, José; Katzke, Verena; Kühn, Tilman; Sacerdote, Carlotta; Schulze, Matthias B.; Skeie, Guri; Ramne, Stina; Ward, Heather; Gunter, Marc J.; Huybrechts, Inge (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-20)
      Background and aims: This study aimed to expand the European Prospective Investigation into Cancer and Nutrition (EPIC) nutrient database (ENDB) by adding amino acid (AA) values, using the U.S. nutrient database (USNDB). Additionally, we aimed to evaluate these new protein and AA intake estimates from the EPIC dietary questionnaires (DQ) and 24- h dietary recalls (24-HDR) using different matching ...

    • Inflammation, hypertension, and microRNA and Prostate Cancer. The Prostate Cancer throughout life (PROCA-life) study 

      Stikbakke, Einar (Doctoral thesis; Doktorgradsavhandling, 2022-03-31)
      <p><i>Background/Aims:</i> Prostate cancer (PCa) is the most common cancer among men in Norway as well as world-wide, and a major cause of health loss and death with 1.4 million new cases and 375 000 deaths world-wide in 2020. Biological mechanisms involved in PCa development are mainly unknown, but chronic inflammation, one hallmark of cancer development, has been questioned to play a key role in ...

    • Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy 

      Nthiga, Thaddaeus Mutugi; Shrestha, Birendra Kumar; Bruun, Jack-Ansgar; Larsen, Kenneth Bowitz; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-19)
      The Golgi complex is essential for the processing, sorting, and trafficking of newly synthesized proteins and lipids. Golgi turnover is regulated to meet different cellular physiological demands. The role of autophagy in the turnover of Golgi, however, has not been clarified. Here we show that CALCOCO1 binds the Golgi-resident palmitoyltransferase ZDHHC17 to facilitate Golgi degradation by autophagy ...

    • Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer 

      Fleten, Karianne Giller; Eksteen, Johannes J.; Mauseth, Brynjar; Camilio, Ketil André; Vasskog, Terje; Sveinbjørnsson, Baldur; Rekdal, Øystein; Mælandsmo, Gunhild Mari; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-24)
      Oncolytic peptides represent a novel, promising cancer treatment strategy with activity in a broad spectrum of cancer entities, including colorectal cancer (CRC). Cancer cells are killed by immunogenic cell death, causing long-lasting anticancer immune responses, a feature of particular interest in non-immunogenic CRC. Oncolytic peptides DTT-205 and DTT-304 were administered by intratumoral injection ...

    • Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score 

      Aleksandrova, Krasimira; Reichmann, Robin; Kaaks, Rudolf; Jenab, Mazda; Bueno-de-Mesquita, Hendrik Bastiaan; Dahm, Christina C.; Eriksen, Anne Kirstine; Tjønneland, Anne; Artaud, Fanny; Boutron-Ruault, Marie-Christine; Hüsing, Anika; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Panico, Salvatore; Grioni, Sara; Sacerdote, Carlotta; Tumino, Rosario; Elias, Sjoerd G.; May, Anne M.; Sandanger, Torkjel M; Skeie, Guri; Sánchez, Maria-Jose; Huerta, José María; Sala, Núria; Gurrea, Aurelio Barricarte; Amiano, Pilar; Drake, Isabel; van Guelpen, Bethany; Key, Tim; Weiderpass, Elisabete; Aglago, Elom K.; Cross, Amanda J.; Tsilidis, Konstantinos K.; Riboli, Elio; Gunter, Marc J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-04)
      <b>Background</b> Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle information into individualized CRC risk assessment has not been implemented. Lifestyle-based risk models may aid the identification of high-risk individuals, guide referral ...

    • Protein signature predicts response to neoadjuvant treatment with chemotherapy and bevacizumab in HER2-negative breast cancers 

      Haugen, Mads Haugland; Lingjærde, Ole Christian; Hedenfalk, Ingrid; Garred, Øystein; Borgen, Elin; Loman, Niklas; Hatschek, Thomas; Børresen-Dale, Anne-Lise; Naume, Bjørn; Mills, Gordon B.; Mælandsmo, Gunhild Mari; Engebråten, Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-28)
      <p>PURPOSE: Antiangiogenic therapy using bevacizumab has proven effective for a number of cancers; however, in breast cancer (BC), there is an unmet need to identify patients who benefit from such treatment. <p>PATIENTS AND METHODS: In the NeoAva phase II clinical trial, patients (N = 132) with large (≥ 25 mm) human epidermal growth factor receptor 2 (HER2)-negative primary tumors were randomly ...

    • Covid-19 transmission in fitness centers in Norway - a randomized trial 

      Helsingen, Lise Mørkved; Løberg, Magnus; Gjøstein, Dagrun Kyte; Wieszczy, Paulina; Olsvik, Ørjan; Juul, Frederik Emil; Barua, Ishita; Jodal, Henriette C.; Herfindal, Magnhild; Mori, Yuichi; Jore, Solveig; Lund-Johansen, Fridtjof; Fretheim, Atle; Bretthauer, Michael; Kalager, Mette (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-16)
      Background: Closed fitness centers during the Covid-19 pandemic may negatively impact health and wellbeing. We assessed whether training at fitness centers increases the risk of SARS-CoV-2 virus infection.<p> <p>Methods: In a two-group parallel randomized controlled trial, fitness center members aged 18 to 64 without Covid-19-relevant comorbidities, were randomized to access to training at a ...

    • Antibiotic Resistance in Oral Streptococci: The prevalence, diversity, stability, and fitness cost of Tn916 -Tn1545 family in oral streptococcal isolates 

      Lunde, Tracy Munthali (Doctoral thesis; Doktorgradsavhandling, 2022-03-25)
      Oral streptococci are important members of the oral microbiome that are gathering more attention due to the presence of antimicrobial resistance determinants and their association with mobile genetic elements. Mobile genetic elements such as the ICE, Tn916 are abundant in bacterial populations and have been implicated in the spread of antibiotic resistance. Despite their abundance, little is known ...