Det helsevitenskapelige fakultet: Recent submissions
Now showing items 3421-3440 of 10469
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TPS-grupper i praksis (Tverrprofesjonell samarbeidslæring i praksisstudier) Delprosjekt 1b i OPERASJON BACHELORPRAKSIS, FHS
(Research report; Forskningsrapport, 2021)I denne rapporten presenteres modeller for tverrprofesjonell praksis-læring som benyttes både i primærhelsetjenester (TVEPS) og i spesialisthelsetjenesten (TPS i sykehuspraksis). I tillegg presenteres en mal for informasjonsskriv til ledere og veiledere i helseforetak og kommuner, der det oppfordres til å legge til rette for tverrprofesjonelt studentsamarbeid når studenter fra flere profesjons ... -
Organizing work in local service implementation: an ethnographic study of nurses’ contributions and competencies in implementing a municipal acute ward
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-19)<i>Background</i> - The increased prevalence of chronic diseases and an ageing population challenge healthcare delivery, particularly hospital-based care. To address this issue, health policy aims to decentralize healthcare by transferring responsibility and introducing new services in primary healthcare. In-depth knowledge of associated implementation processes is crucial for health care managers, ... -
Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-17)Clinical data on the transfer of triptans into human breast milk remain scarce. In a lactation study including 19 breastfeeding women with migraine, we examined the excretion of six different triptans into milk. Following intake of a single dose, each participant collected seven breast milk samples at predefined intervals up to 24 hours after dose. Triptan concentrations in milk were measured using ... -
Proteomic analyses identify major vault protein as a prognostic biomarker for fatal prostate cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-20)The demographic shift toward an older population will increase the number of prostate cancer cases. A challenge in the treatment of prostate cancer is to avoid undertreatment of patients at high risk of progression following curative treatment. These men can benefit from early salvage treatment. An explorative cohort consisting of tissue from 16 patients who underwent radical prostatectomy, and were ... -
The cardiac impact of cisplatin-based chemotherapy in survivors of testicular cancer: A 30-year follow-up
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-05)Aims - Cisplatin-based chemotherapy (CBCT) is essential in the treatment of metastatic testicular cancer (TC) but has been associated with long-term risk of cardiovascular morbidity and mortality. Furthermore, cisplatin can be detected in the body decades after treatment. We aimed to evaluate the long-term impact of CBCT on cardiac function and morphology in TC survivors 30 years after treatment.< ... -
Individualized dietary counseling on nutritional status in head and neck cancer patients undergoing radiotherapy: A systematic review
(Master thesis; Mastergradsoppgave, 2021-07-08)Individualized dietary counseling given with or without oral nutritional supplements, on the outcome of nutritional status, in head and neck cancer patients undergoing radiotherapy, compared to standard routine clinical care, with or without other nutritional interventions: A systematic review. Background: Malnutrition and unintentional weight loss is common in patients with head and neck cancer. ... -
Vegen til toppfotballen. Ein studie av spelarutvikling på norske toppfotballspelarar
(Master thesis; Mastergradsoppgave, 2021-05-14)I denne masteroppgåva har eg sitt på kva delar av miljøet rundt den norske toppfotballspelaren som har vore viktig for å ha nådd norsk toppfotball for menn og kvinner. Eg har brukt ein holistisk økologisk tilnærming. Ei slik tilnærming gjer at det er mogleg å sjå etter og finne komponentar som enten påverkar toppfotballspelaren eller miljømessige suksessfaktorar. Talentutviklingsmiljø-modellen og ... -
Explaining subjective social status in two countries: The relative importance of education, occupation, income and childhood circumstances
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-03)In the literature on social inequalities in health, subjective socioeconomic position (SEP) is increasingly applied as a determinant of health, motivated by the hypothesis that having a high subjective SEP is health-enhancing. However, the relative importance of determinants of subjective SEP is not well understood. Objective SEP indicators, such as education, occupation and income, are assumed to ... -
Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-27)We report a series of synthetic cationic amphipathic barbiturates inspired by the pharmacophore model of small antimicrobial peptides (AMPs) and the marine antimicrobials eusynstyelamides. These N,N′-dialkylated-5,5-disubstituted barbiturates consist of an achiral barbiturate scaffold with two cationic groups and two lipophilic side chains. Minimum inhibitory concentrations of 2–8 μg/mL were achieved ... -
Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-28)Background - The gut microbiota represents a potential treatment target in heart failure (HF) through microbial metabolites such as trimethylamine N-oxide (TMAO) and systemic inflammation. Treatment with the probiotic yeast Saccharomyces boulardii have been suggested to improve left ventricular ejection fraction (LVEF).<p> <p>Methods - In a multicentre, prospective randomized open label, blinded ... -
Concentrations and geographical patterns of persistent organic pollutants (POPs) in meat from semi-domesticated reindeer (Rangifer tarandus tarandus L.) in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-29)The study aimed at investigating the concentrations and geographical patterns of 11 polychlorinated biphenyls (PCBs) and 15 organochlorine pesticides (OCPs) in reindeer muscle samples (n = 100) collected from 10 grazing districts in Norway, 2009. Concentrations were examined for patterns related to geographical region as well as age and sex of animals. Concentrations measured for PCBs and OCPs in ... -
GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-11)Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on AAD, which identifies nine independent risk loci (P < 5 × 10−8). In addition to loci implicated in lymphocyte function and development shared with other ... -
Organization and orchestration of male rat sexual behavior
(Doctoral thesis; Doktorgradsavhandling, 2021-09-07)Sexual behavior is innately motivated and rewarding. The underlying neurobiological mechanisms of sexual motivation, copulation, and sexual reward have not been completely unraveled. This thesis gives insight in the structure, organization, and neurobiological orchestration of male rat sexual behavior. The research presented in this thesis demonstrates that a more extensive behavioral annotation ... -
Family involvement in the intensive care unit in four Nordic countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-17)Background - Relevance to clinical practice The findings from the study highlighting family involvement, high-quality communication and flexible visiting policy as central aspects of family care may inspire clinicians to identify aspects of everyday family care in their ICUs calling for further improvement.<p> <p>Aims and objectives - To describe family involvement, communication practices and ... -
“No Evidence of Disease Activity” (NEDA) hos pasienter med multippel sklerose ved Nordlandssykehuset
(Master thesis; Mastergradsoppgave, 2019-08-19)Bakgrunn: Multippel sklerose er en kronisk demyeliniserende sykdom som man i dag ikke har en kurativ behandling for. Med moderne MS-behandling endres behandlingsmålene for pasienter. «No evidence of disease activity» - NEDA – betyr at pasienter ikke har tegn til sykdom ved funksjonsforverring, attakker eller nye lesjoner på MR over en viss tidsperiode. NEDA er foreslått som mål for behandling av ... -
Konsekvenser av covid-19 på barn og unges liv og helse: en hurtigoversikt
(Research report; Forskningsrapport, 2021-01)Oppdraget var å kartlegge og hente ut resultater fra studier publisert om covid-19-pandemiens og samfunnsnedstengningens følger for barn og unge. Problemstillingen var: Hva er konsekvensene av covid-19-pandemien på barn og unges liv og helse?<p> <p>Vi gjennomførte en hurtigoversikt, dvs. en systematisk oversikt utført på kortere tid og med forenklede steg. Vi vurderte ikke studienes risiko ... -
Parent satisfaction with child health centres for children 0–5 years old in Norway: A cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-10)In Norway, all children are entitled to receive regular health checks. Child health centres for children 0–5 years old (CHC) provide these check-ups and are one of many health services that Norwegian municipalities have to offer. The aim of this study was to examine parents’ satisfaction with CHCs, and to identify predictors for the overall evaluation of the service. The sample comprised 1654 parents ... -
Koronapandemien gjorde babyforskning ved UiT lettere
(Journal article; Tidsskriftartikkel, 2021-02-05)Da Norge stengte ned 12. mars trodde psykologistipendiat Solveig Flatebø at det ble kroken på lab-døra. Der tok hun feil. -
Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-29)Background - Prostate cancer tissues are inherently heterogeneous, which presents a challenge for metabolic profiling using traditional bulk analysis methods that produce an averaged profile. The aim of this study was therefore to spatially detect metabolites and lipids on prostate tissue sections by using mass spectrometry imaging (MSI), a method that facilitates molecular imaging of heterogeneous ... -
Intimate partner violence and its association with mental health problems: The importance of childhood violence – The SAMINOR 2 Questionnaire Survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-30)Aims: This study aims to estimate the prevalence of intimate partner violence (IPV) and its association with psychological distress and symptoms of post-traumatic stress (PTS) among Sami and non-Sami and to explore whether the association between IPV and mental health is modified by exposure to childhood violence (CV). These issues are scarcely studied among the Sami. Methods: This study was based ...