BACKGROUND Oral Squamous Cell Carcinoma (OSCC) is the most common type of head and neck cancer and persists a leading cause of cancer associated mortality and morbidity universally. Survival rate is still poor at less than 50% urging the need for biomarkers to allow better diagnosis, prognosis and therapeutic strategies. In this study we focus on E2F4, a repressor of cell cycle, and further propose ...

Aim - To systematically review human metabolomic studies investigating metabolic responses in septic neonates.<p> <p>Methods - A systematic literature search was performed in the databases MEDLINE, EMBASE and Cochrane library up to the 1st of January 2021. We included studies that assessed neonatal sepsis and the following outcomes; (1) change in the metabolism compared to healthy neonates and/or ...

The assessment of sexual behavior in male rats with the aim of unraveling underlying neurobiological mechanisms has in the recent decades been reduced to the annotation of mounts, intromissions and ejaculations. To provide a better understanding of the structure and patterns of copulation, it is necessary to extend and tailor the analysis to the natural organization of male rat copulation. This will ...

Successful treatment of skin infections requires eradication of biofilms found in up to 90 % of all chronic wounds, causing delayed healing and increased morbidity. We hypothesized that chitosan hydrogel boosts the activity of liposomally-associated membrane active antimicrobials (MAA) and could potentially improve bacterial and biofilm eradication. Therefore, liposomes (∼300 nm) bearing chlorhexidine ...

Introduction: The incidence of pancreatic cancer is increasing worldwide and characterized by a particularly low survival rate. Studies have reported weak and inconsistent evidence for associations among reproductive factors, use of exogenous hormones, and pancreatic cancer incidence in women. <p> <p>Purpose: To investigate relationships between reproductive factors, exogenous hormones, and the ...

Objective - The aim of this integrative review was to identify facilitators and barriers to patients’ well-being when being cared for in an ICU setting, from the perspective of the patients.<p> <p>Background - To become critically ill and hospitalised in an ICU is a stressful, chaotic event due to the life-threatening condition itself, as well as therapeutic treatments and the environment. A ...

Background - Vancomycin-resistant enterococci (VRE) represent several types of transferable vancomycin resistance gene clusters. The vanD type, associated with moderate to high level vancomycin resistance, has only sporadically been described in clinical isolates. The aim of this study was to perform a genetic characterization of the first VanD-type VRE strains detected in Norway.<p> <p>Methods ...

Background - In families where one of the siblings has an eating disorder (ED), research indicates that the siblings without eating disorders (EDs) experience insufficient care and negative changes in family life. The illness then takes up a great deal of space within the family. Support from the siblings without EDs is considered to be important for the recovery of the sibling with ED. A key issue ...

The aim of this study is to investigate the association between childhood sensorineural hearing loss (CSNHL) and divorce in a large, Norwegian cohort. Data from the School Hearing Investigation in Nord-Trøndelag (SHINT), Norway, are combined with registry data on marital status from Statistics Norway and matched controls from the Nord-Trøndelag Health Study (HUNT). The sample includes a total of ...

Flere faktorer bidrager til at påvirke den kliniske holdbarhed på cementerede tandrestaureringer. Fordi præparationen af tandvæv til en ekstrakoronal restaurering er irreversibel, udfoldes der stor forskningsaktivitet for at finde metoder og teknikker, der kan minimere biologisk skade, og udvikle nye biomaterialer, som kræver mindre fjernelse af tandvæv. Derfor bliver vi konstant bombarderet med nye ...