Viser treff 1461-1480 av 10439

    • All roads lead to the lysosome: exploring the degradation of TNIP1 by selective autophagy 

      Rasmussen, Nikoline Lander (Doctoral thesis; Doktorgradsavhandling, 2023-04-21)
      Selective autophagy is important for maintaining cellular homeostasis. Generally, autophagy is considered cytoprotective and anti-inflammatory, acting to limit infection and accumulation of deleterious material. Key to this function is the ability to select cargo to be degraded, and here, selective autophagy receptors play a central role. In this thesis, we show that the anti-inflammatory and ...
    • Natural Language Processing and Psychosis: On the Need for Comprehensive Psychometric Evaluation 

      Cohen, Alex S.; Rodriguez, Zachary; Warren, Kiara K.; Cowan, Tovah; Masucci, Michael D.; Edvard Granrud, Ole; Holmlund, Terje Bektesevic; Chandler, Chelsea; Foltz, Peter W.; Strauss, Gregory P. (Journal article; Tidsskriftartikkel, 2022-06-23)
      <p><i>Background and Hypothesis:</i> Despite decades of “proof of concept” findings supporting the use of Natural Language Processing (NLP) in psychosis research, clinical implementation has been slow. One obstacle reflects the lack of comprehensive psychometric evaluation of these measures. There is overwhelming evidence that criterion and content validity can be achieved for many purposes, ...
    • Making wise decisions for completion thyroidectomies 

      Brun, Vegard Heimly; Brauckhoff, Katrin (Journal article; Tidsskriftartikkel, 2022-11-25)
      <p>Unilateral differentiated thyroid cancer (DTC) <4 cm can be treated with thyroid lobectomy or total thyroidectomy (TT), depending on the presence of high-risk features. Information about some of these features, such as micrometastasis in lymph nodes or microscopic extrathyroidal extension (ETE), are usually incidental findings that only become available after histological assessment from the first ...
    • Changes in management preference of deep carious lesions and exposed pulps: questionnaire studies with a 10-year interval among dentists in Lithuania 

      Stangvaltaite-Mouhat, Lina; Stankeviciene, Indre; Brukiene, Vilma; Puriene, Alina; Drachev, Sergei Nikolaevich (Journal article; Tidsskriftartikkel, 2022-02)
      We aimed to investigate changes in management preferences for deep carious lesions and pulps exposed during carious tissue removal that occurred during the last 10 years and identify associated dentists’ background factors. The data were collected among dentists registered with the Lithuanian Dental Chamber at two time points using a similar questionnaire. In 2011, 400 randomly selected dentists ...
    • Trening med mening - En kvalitativ studie av klatrende ungdom 

      Jensen, Ove Røe (Master thesis; Mastergradsoppgave, 2023-01-13)
      Studien undersøker betydninger klatring har for ungdom som klatrer innendørs. Forskningsspørsmålene som stilles er: Hvordan framtrer sosiale samhandlingsmønstre? Hvilke forhold gir status på feltet? Hvilke betydninger tillegger klatrere sosiale fellesskap? Studiens empiri tar utgangspunkt i kvalitative intervju med ungdom i alderen 19-35 år som er organisert i ulike klubber i Finnmark. Sportifisering ...
    • European student wellness, stress, coping, support and perceptions about remote dental training during COVID-19 

      Aleksejuniene, Jolanta; Hysi, Dorjan; Nikolovovska, Julijana; Stangvaltaite-Mouhat, Lina; Chałas, Renata; Oancea, Roxana; Richardas, Kubilius; Lipski, Mariusz; Sarna-Boś, Katarzyna; Puriene, Alina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-06)
      <p><i>Objectives:</i> The aim of this study was to compare wellness, stress, ability to cope, social support and perceptions about remote training amongst European dental students during COVID-19. <p><i>Methods:</i> 1795 undergraduate dental students from six countries and eight dental schools participated. The anonymous survey collected data about different aspects in each of the following domains: ...
    • Hazardous Alcohol Use and Insomnia in women and men: Insights from the population-based Tromsø Study 2015-2016. 

      Husberg, Vendela (Mastergradsoppgave; Master thesis, 2021-03-23)
      Background and aims: Hazardous alcohol use is known to be comorbid with insomnia. The aim of this study was to estimate the prevalence of co-occurring hazardous alcohol use and insomnia symptoms, and the odds of insomnia among women and men with a hazardous alcohol use, using logistic regression and covariate-adjusted moderation analysis. Design setting: Cross-sectional data from the seventh survey ...
    • Effects of instagram sports posts on the athletic motivation of female elite athletes: Do they inspire or backfire? 

      Weber, Silvana; Olsen, Marte; Martiny, Sarah E. (Journal article; Tidsskriftartikkel, 2021-10-08)
      The social networking site Instagram provides users with an abundance of photos and information in many domains including sports. The posts are often intended to inspire and motivate users. We argue that the display of success and failure of professional athletes may influence elite athletes’ own sports ambitions. Research has shown that exposure to positive ingroup stereotypes and exposure to ...
    • The Risk of Venous Thromboembolism Attributed to Established Prothrombotic Genotypes 

      Holtet Evensen, Line; Arnesen, Carl-Arne; Rosendaal, Frits Richard; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hveem, Kristian; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel, 2022-01-17)
      <p><i>Background -</i> The proportion of venous thromboembolism (VTE) events that can be attributed to established prothrombotic genotypes has been scarcely investigated in the general population. We aimed to estimate the proportion of VTEs in the population that could be attributed to established prothrombotic genotypes using a population-based case-cohort. <p><i>Methods -</i> Cases with incident ...
    • Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy 

      Javary, Joaquim; Goupil, Eugénie; Soulez, Mathilde; Kanshin, Evgeny; Bouchard, Antoine; Seternes, Ole Morten; Thibault, Pierre; Labbé, Jean-Claude; Meloche, Sylvain (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-28)
      Extracellular signal-regulated kinase 3 (ERK3) is a poorly characterized member of the mitogen-activated protein (MAP) kinase family. Functional analysis of the ERK3 signaling pathway has been hampered by a lack of knowledge about the substrates and downstream effectors of the kinase. Here, we used large-scale quantitative phosphoproteomics and targeted gene silencing to identify direct ERK3 substrates ...
    • No Effect of Calanus Oil on Maximal Oxygen Uptake in Healthy Participants: A Randomized Controlled Study 

      Tauschek, Lucas Christian; Røsbjørgen, Ragnhild; Dalen, Håvard; Larsen, Terje; Karlsen, Trine (Journal article; Tidsskriftartikkel, 2022-08-23)
      We aimed to investigate the long-term effect of daily Calanus oil supplementation on maximal oxygen uptake (VO<sub>2</sub>max) in healthy 30- to 50-year-old participants. The study was motivated by preclinical studies reporting increased VO<sub>2</sub>max and metabolic health with omega-3 rich Calanus oil. In a double-blinded study, 71 participants were randomized to receive 2 g/day of Calanus or ...
    • Timed Up and Go in People with Subjective Cognitive Decline Is Associated with Faster Cognitive Deterioration and Cortical Thickness 

      Borda, Miguel Germán; Ferreira, Daniel; Selnes, Per; Tovar-Rios, Diego Alejandro; Jaramillo-Jiménez, Alberto; Kirsebom, Bjørn-Eivind; Garcia-Cifuentes, Elkin; Dalaker, Turi Olene; Oppedal, Ketil; Sønnesyn, Hogne; Fladby, Tormod; Aarsland, Dag (Journal article; Tidsskriftartikkel, 2022-04)
      <p><i>Introduction:</i> Early markers of neurodegeneration provide an opportunity to detect, monitor, and initiate interventions in individuals who have an increased risk of developing dementia. Here, we investigated whether the Timed Up and Go (TUG) test is associated with early brain neurodegeneration and whether the TUG test could be a marker of cognitive decline in people with subjective cognitive ...
    • High prevalence of Merkel cell polyomavirus is associated with dysregulation in transcript levels of TLR9 and type I IFNs in a large cohort of CF patients from the Italian (Lazio) reference center for cystic fibrosis 

      Bitossi, Camilla; Viscido, Agnese; Prezioso, Carla; Brazzini, Gabriele; Trancassini, Maria; Borrazzo, Cristian; Passerini, Sara; Frasca, Federica; Scordio, Mirko; Sorrentino, Leonardo; Oliveto, Giuseppe; Fracella, Matteo; D'Auria, Alessandra; Selvaggi, Carla; Cimino, Giuseppe; Midulla, Fabio; Pierangeli, Alessandra; Antonelli, Guido; Moens, Ugo Lionel; Pietropaolo, Valeria; Scagnolari, Carolina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-13)
      Merkel cell polyomavirus (MCPyV) has been detected in respiratory specimens including those from Cystic Fibrosis (CF) patients, raising questions about its immunological and clinical relevance in the respiratory tract. MCPyV might promote an inappropriate antiviral response contributing to a chronic inflammatory response and resulting in detrimental effects in CF. Respiratory samples (n = 1138) were ...
    • Overexpression of miR-20a-5p in Tumor Epithelium Is an Independent Negative Prognostic Indicator in Prostate Cancer — A Multi-Institutional Study 

      Stoen, Maria J.; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona I.; Ingebriktsen, Lise M.; Donnem, Tom; Lombardi, Ana P. G.; Kilvaer, Thomas K.; Busund, Lill-Tove R.; Richardsen, Elin (Master thesis; Mastergradsoppgave; Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-26)
      <p><i>Background:</i> MicroRNAs (miRs) have critical regulatory roles in cell functions, and are involved in prostate cancer tumorigenesis. miR-20a-5p is a member of the oncogenic miR-17-92 cluster. Overexpressed miR-20a-5p has been shown to increase both cell proliferation and cell migration in cancers. The aim of our cohort study was to evaluate the prognostic role of miR-20a-5p in prostate cancer. ...
    • Mobile app as a tool to collect health data: a survey on vaccination against COVID-19 

      Krieger, E.A.; Kudryavtsev, Alexander V; Samodova, O.V.; Bashkirev, D.S.; Mitkin, N.A.; Kontsevaya, A.V.; Postoev, V.A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022)
      Objective. To evaluate the feasibility of using a mobile app to collect health-related data and the impact of this data collection method on the results obtained, using the COVID-19 vaccination attitude assessment as an example. Material and methods. A survey was conducted on attitudes towards COVID-19 vaccination using the «Know Your Heart» mobile app. A total of 1,770 Arkhangelsk region residents ...
    • Regression-based norms for the FAS phonemic fluency test for ages 40–84 based on a Norwegian sample 

      Lorentzen, Ingrid Myrvoll; Espenes, Jacob; Hessen, Erik; Waterloo, Knut; Bråthen, Geir; Timón, Santiago; Aarsland, Dag; Fladby, Tormod; Bjørn-Eivind, Kirsebom (Mastergradsoppgave; Master thesis, 2023-01-06)
      The FAS phonemic fluency test is a commonly used neuropsychological test of executive function and processing speed. Although Norwegian discrete norms have been developed for the FAS test, American regression-based norms are frequently used by clinicians in Norway. However, language and cultural differences impact performance on the FAS test, and using foreign norms may not be appropriate. Moreover, ...
    • Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors 

      Thibord, Florian; Klarin, Derek; Brody, Jennifer A.; Chen, Ming-Huei; Levin, Michael G.; Chasman, Daniel I.; Goode, Ellen L.; Hveem, Kristian; Teder-Laving, Maris; Martinez-Perez, Angel; Aïssi, Dylan; Daian-Bacq, Delphine; Ito, Kaoru; Natarajan, Pradeep; Lutsey, Pamela L.; Nadkarni, Girish N.; de Vries, Paul S.; Cuellar-Partida, Gabriel; Wolford, Brooke N.; Pattee, Jack W.; Kooperberg, Charles; Brækkan, Sigrid Kufaas; Li-Gao, Ruifang; Saut, Noemie; Sept, Corriene; Germain, Marine; Judy, Renae L.; Wiggins, Kerri L.; Ko, Darae; O'Donnell, Christopher J.; Taylor, Kent D.; Giulianini, Franco; De Andrade, Mariza; Nøst, Therese Haugdahl; Boland, Anne; Empana, Jean-Philippe; Koyama, Satoshi; Gilliland, Thomas; Do, Ron; Huffman, Jennifer E.; Wang, Xin; Zhou, Wei; Manuel Soria, Jose; Carlos Souto, Juan; Pankratz, Nathan; Haessler, Jeffery; Hindberg, Kristian Dalsbø; Rosendaal, Frits R; Turman, Constance; Olaso, Robert; Kember, Rachel L.; Bartz, Traci M.; Lynch, Julie A.; Heckbert, Susan R.; Armasu, Sebastian M.; Brumpton, Ben Michael; Smadja, David M.; Jouven, Xavier; Komuro, Issei; Clapham, Katharine R.; Loos, Ruth J F; Willer, Cristen J.; Sabater-Lleal, Maria; Pankow, James S.; Reiner, Alexander P.; Morelli, Vania Maris; Ridker, Paul M.; Vlieg, Astrid van Hylckama; Deleuze, Jean-François; Kraft, Peter; Rader, Daniel J.; Psaty, Bruce M.; Skogholt, Anne Heidi; Emmerich, Joseph; Suchon, Pierre; Rich, Stephen S.; Vy, Ha My T; Tang, Weihong; Jackson, Rebecca D.; Hansen, John Bjarne; Morange, Pierre-Emmanuel; Kabrhel, Christopher; Trégouët, David-Alexandre; Damrauer, Scott M.; Johnson, Andrew D.; Smith, Nicholas L. (Journal article; Tidsskriftartikkel, 2022)
      <p><i>Background:</i> Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases and identified up to 40 genetic loci associated with VTE risk, including loci not previously suspected to play a role in hemostasis. The aim of our research was to expand ...
    • Factors associated with treatment satisfaction in patients with hidradenitis suppurativa: results from the Global VOICE project 

      Midgette, Bria; Strunk, Andrew; Akilov, Oleg; Alavi, Afsaneh; Ardon, Christine; Bechara, Falk G.; Cohen, Arnon D.; Cohen, Steven; Daveluy, Steven; del Marmol, Véronique; Delage, Maïa; Esmann, Solveig; Fisher, Shani; Giamarellos-Bourboulis, Evangelos J.; Glowaczewska, Amelia; Goldfarb, Noah; Brant, Elena Gonzalez; Grimstad, Øystein; Guilbault, Sandra; Hamzavi, Iltefat; Hughes, Rosalind; Ingram, John R.; Jemec, Gregor B.E.; Ju, Qiang; Kappe, Naomi; Kirby, Brian; Kirby, Joslyn S.; Lowes, Michelle A.; Matusiak, Lukasz; Micha, Stella; Micheletti, Robert; Miller, Angela P.; Moseng, Dagfinn; Naik, Haley; Nassif, Aude; Nikolakis, Georgios; Paek, So Yeon; Pascual, Jose Carlos; Prens, Errol; Resnik, Barry; Riad, Hassan; Sayed, Christopher; Smith, Saxon D.; Soliman, Yssra; Szepietowski, Jacek C.; Tan, Jerry; Thorlacius, Linnea; Tzellos, Thrasyvoulos; van der Zee, Hessel H.; Villumsen, Bente; Wang, Lanqi; Zouboulis, Christos; Garg, Amit (Journal article; Tidsskriftartikkel, 2022-12-01)
      <p><i>Background</i> Nearly half of patients with hidradenitis suppurativa (HS) report dissatisfaction with their treatment. However, factors related to treatment satisfaction have not been explored. <p><i>Objectives</i> To measure associations between treatment satisfaction and clinical and treatment‐related characteristics among patients with HS. <p><i>Methods</i> Treatment satisfaction was ...
    • Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: A meta-analysis in Europeans 

      Mauschitz, Matthias M.; Verzijden, Timo; Schuster, Alexander K.; Elbaz, Hisham; Pfeiffer, Norbert; Khawaja, Anthony; Luben, Robert N.; Foster, Paul J.; Rauscher, Franziska G.; Wirkner, Kerstin; Kirsten, Toralf; Jonas, Jost B.; Bikbov, Mukharram M.; Hogg, Ruth; Peto, Tunde; Cougnard-Grégoire, Audrey; Bertelsen, Geir; Erke, Maja Gran; Topouzis, Fotis; Giannoulis, Dimitrios A.; Brandl, Caroline; Heid, Iris M.; Creuzot-Garcher, Catherine P.; Gabrielle, Pierre-Henry; Hense, Hans-Werner; Pauleikhoff, Daniel; Barreto, Patricia; Coimbra, Rita; Piermarocchi, Stefano; Daien, Vincent; Holz, Frank G.; Delcourt, Cecile; Finger, Robert P. (Journal article; Tidsskriftartikkel, 2022-11-07)
      <p><i>Background/aims</i> To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. <p><i>Methods</i> We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent ...
    • Note to first-year university students: Just do it! In the end, the fact that you study may be more important than how you study. 

      Sæle, Rannveig Grøm; Dahl, Tove I.; Sørlie, Tore; Friborg, Oddgeir (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-20)
      Education is important to society, yet many students do not complete the educations they start. In the present study of 426 students at a Norwegian university, we examined the predictive value of study-related variables with regard to student status one and five years after initial enrollment (stayers versus dropouts). The logistic regression analyses indicated that older students and students who ...