Background: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with ...

Background<p> <p>Pulmonary hypertension (PH) is a devastating potential complication of pulmonary embolism, a manifestation of venous thromboembolism (VTE). The incidence of and risk factors for PH in those with prior VTE are poorly characterized. <p>Methods and Results <p>International Classification of Diseases (ICD) codes from inpatient and outpatient medical claims from MarketScan administrative ...

Introduction Depression is a common mental disorder and the (global) leading cause of all non-fatal burden of disease worldwide. Currently, supported treatment for depression is antidepressant medication and different psychotherapeutic interventions. Many patients experience, however, adverse effects of antidepressant medication, while at the same time the access to psychotherapeutic interventions ...

Underlying patterns and factors behind suicides of patients in treatment are still unclear and there is a pressing need for more studies to address this knowledge gap. We analysed 278 cases of suicide reported to The Norwegian System of Patient Injury Compensation, drawing on anonymised data, i.e., age group, gender, diagnostic category, type of treatment provided, inpatient vs. outpatient status, ...

A high proportion of people with severe mental illness (SMI) want to work, consider it essential for recovery, yet employment rates are low. Many employees in public employment services (PES) work according to traditional attitudes that people with SMI are unable to work and if they do, risk harm from work-related stress. These attitudes conflict with principles in evidence based vocational ...

Til tross for en god fødselsomsorg i Norge skjer det uønskede hendelser med alvorlig utfall for mor og/eller barn. I media kan man jevnlig lese om alvorlige hendelser i forbindelse med fødsel, der tema ofte er dødsfall eller skade som følge av manglende eller feil helsehjelp. Disse historiene gjør inntrykk.<p> <p>Det er ikke bare den berørte familien som blir hardt rammet, det er også de involverte ...

Introduction<p> <p>Liver sinusoidal endothelial cells (LSECs) are specialized fenestrated scavenger endothelial cells involved in the elimination of modified plasma proteins and tissue turnover waste macromolecules from blood. LSECs also participate in liver immune responses. A challenge when studying LSEC biology is the rapid loss of the in vivo phenotype in culture. In this study, we have ...

Background: Patients with wake-up ischemic stroke are frequently excluded from thrombolytic treatment due to unknown symptom onset time and limited availability of advanced imaging modalities. The Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST) is a randomized controlled trial of intravenous tenecteplase 0.25 mg/kg and standard care versus standard care alone (no thrombolysis) in patients ...

Background Although several studies from Europe and the US have shown promising screening results favoring digital breast tomosynthesis compared with standard digital mammography (DM), both costs and efects of implementing tomosynthesis in routine screening programs remain uncertain. The cost efectiveness of using tomosynthesis in routine screening is debated in the literature, and model inputs ...

Research has demonstrated that inflammation is a central part of several psychiatric disorders, of which depression in the most researched condition. Most studies have, however, been conducted on younger adults, and studies on elderly are scarce. This thesis explores the possible association between systemic markers of inflammation and characteristics of older psychiatric patients. In study I, ...