Det helsevitenskapelige fakultet: Nye registreringer

Viser treff 21-40 av 10438

    • Accumulation and removal of Streptococcus mutans biofilm on enamel and root surfaces in vitro 

      Breivik, Anne; Mulic, Aida Gacic; Sehic, Amer; Valen, Håkon; Kopperud, Simen E.; Stein, Linda Maria; Khan, Qalbi (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-12)
      Objective: This study aimed to quantitatively investigate the accumulation of Streptococcus mutans biofilm on enamel and root surfaces and assess the amount of biofilm removal using (1) experimental toothpaste and (2) water, in a closed system of flow chamber.<p> <p<Methods: Eight sound premolars were embedded in epoxy resin and polished with silicon carbide grinding papers to display enamel ...

    • Raynaud’s phenomenon in the feet of Arctic open-pit miners 

      Stjernbrandt, Albin; Pettersson, Hans; Vihlborg, Per; Höper, Anje Christina; Aminoff, Anna Louise; Wahlström, Jens; Nilsson, Tohr (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-18)
      The literature on Raynaud’s phenomenon (RP) in the feet is scarce, especially in the occupational setting. The primary aim of our study was to investigate the occurrence of RP in the feet of miners. As part of the MineHealth project, written surveys and clinical examinations were completed by 260 Arctic open-pit miners working in northern Sweden and Norway (participation rate 53.6%). Data on ...

    • Interactions between commensal Enterococcus faecium and Enterococcus lactis and clinical isolates of Enterococcus faecium 

      Wagner, Theresa Maria; Pöntinen, Anna Kaarina; Fenzel, Carolin Kornelia; Engi, Daniel; Janice, Jessin; Almeida-Santos, Ana C.; Tedim, Ana P.; Freitas, Ana R.; Peixe, Luísa; van Schaik, Willem; Johannessen, Mona Susan; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-09)
      Enterococcus faecium (Efm) is a versatile pathogen, responsible for multidrug-resistant infections, especially in hospitalized immuno compromised patients. Its population structure has been characterized by diverse clades (A1, A2, and B (reclassified as E. lactis (Ela)), adapted to different environments, and distinguished by their resistomes and virulomes. These features only partially explain ...

    • A human stomach cell type transcriptome atlas 

      Struck, Eike Christopher; Odeberg, Jacob Olof; Öling, S.; Noreen-Thorsen, M.; Zwahlen, M.; von Feilitzen, K.; Pontén, F.; Lindskog, C.; Butler, Lynn; Uhlén, M.; Dusart, P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-14)
      Background The identification of cell type-specific genes and their modification under different conditions is central to our understanding of human health and disease. The stomach, a hollow organ in the upper gastrointestinal tract, provides an acidic environment that contributes to microbial defence and facilitates the activity of secreted digestive enzymes to process food and nutrients into ...

    • School children’s mental health during the COVID-19 pandemic 

      Martinsen, Kristin; Lisøy, Carina; Wentzel-Larsen, Tore; Neumer, Simon-Peter; Rasmussen, Lene-Mari Potulski; Adolfsen, Frode; Sund, Anne Mari; Ingul, Jo Magne (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-05)
      Introduction: The COVID-19 pandemic significantly impacted the daily routines of children, with social distancing and quarantine leading to reduced social interactions and potential increased conflicts within families. These factors can increase the risk for anxiety and depression while reducing overall quality of life. <p><p>Methods: Our study included 1843 school children aged 8 to 12 from 56 ...

    • Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity 

      Raju, Sajan; Molinaro, Antonio; Awoyemi, Ayodeji Olawale; Jørgensen, Silje Fjellgård; Braadland, Peder Rustøen; Nendl, Andraz; Seljeflot, Ingebjørg; Ueland, Per Magne; McCann, Adrian; Aukrust, Pål; Vestad, Beate; Mayerhofer, Christiane Caroline; Broch, Kaspar; Gullestad, Lars; Lappegård, Knut Tore; Halvorsen, Bente; Kristiansen, Karstein Berge; Hov, Johannes Espolin Roksund; Trøseid, Marius (Journal article; Tidsskriftartikkel, 2024-02-08)
      <p><i>Background</i> Interactions between the gut microbiota, diet, and host metabolism contribute to the development of cardiovascular disease, but a firm link between disease-specific gut microbiota alterations and circulating metabolites is lacking. <p><i>Methods</i> We performed shot-gun sequencing on 235 samples from 166 HF patients and 69 healthy control samples. Separate plasma samples from ...

    • Voksne søsken til barn med komplekse omsorgsbehov sine erfaringer fra grunnskolen 

      Pedersen, Michelle Kristin (Master thesis; Mastergradsoppgave, 2023-09-01)
      <p>Bakgrunn: Søsken til barn med komplekse omsorgsbehov berøres av en oppvekst med alvorlig sykdom i familien. En uforutsigbar hverdag, preget av mange omsorgsoppgaver, lite tilgjengelige foreldre og emosjonelt stress, får også føringer for barnets tilpasning i skolen. I sårbare situasjoner trenger barn trygge og stabile rammer. Søsken som pårørende til en bror eller søster har en lovfestet rett til ...

    • Identifisering av pasienter med hjerneslag ved søk i diagnoseregister på sykehus. Grenseoppgang mellom diagnosen hjerneinfarkt og forbigående ischemisk attakk 

      Wang-Iversen, Rosa Elisabeth Theresia (Master thesis; Mastergradsoppgave, 2020-09-01)
      Bakgrunn: Hjerneslag defineres som en plutselig oppstått fokal eller global forstyrrelse i hjernens funksjoner som vedvarer i mer enn 24 timer og som har vaskulær årsak. Et TIA (transitorisk iskemisk anfall) er tradisjonelt definert på samme måte som et hjerneslag, men med varighet under 24 timer. Denne tidsbaserte definisjonen gjenspeiler i liten grad patofysiologien ved hjerneslag og TIA. Ved økt ...

    • Polarization of primary human renal proximal tubular epithelial cells - a pilot study 

      Lorentzen, Elias Myrvoll (Master thesis; Mastergradsoppgave, 2020-08-31)
      Introduction: Epithelial cells are specialized cells with an apicobasal polarity that allows them to exert their functions, such as acting as a barrier and controlling flow and transport of molecules across the epithelial layer. Polarized epithelial cell models have been developed for several organs and yield a more in vivo-like organization than cell monolayers. BK Polyomavirus (BKPyV) is a ...

    • Metakromatisk leukodystrofi og nye terapimetoder – med fokus på sen-infantil form 

      Færden, Maren Sølverud (Master thesis; Mastergradsoppgave, 2024-05-20)
      Metakromatisk leukodystrofi er en autosomal recessiv arvelig nevrodegenerativ sykdom, hvor myelinet rundt nervefibrene i både det sentrale og det perifere nervesystemet destrueres. Dette resulterer i progressiv motorisk, sensorisk og kognitiv svikt. Sykdommen er forårsaket av mangel på arylsulfatase A lysosomale enzym og sfingolipid aktivator protein B, som en konsekvens av bialleliske mutasjoner i ...

    • Empirically derived dietary patterns in relation to periodontitis and number of teeth among Norwegian adults 

      Petrenya, Natalia; Brustad, Magritt; Hopstok, Laila A.; Holde, Gro Eirin; Jönsson, Birgitta (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-15)
      Objectives: To explore dietary patterns in relation to periodontitis and number of teeth.<p> <p>Design: A cross-sectional study. <p>Setting: We used data from the seventh survey of the Tromsø Study in Norway, 2015–2016. Three periodontitis groups were compared: (i) no periodontitis/slow bone loss; (ii) moderate bone loss; and (iii) rapid bone loss. Number of teeth was categorised as 25–28, ...

    • Can a mock medication-taking learning activity enable pharmacy students to experience the range of barriers and facilitators to medication adherence? An analysis informed by the Theoretical Domains Framework and COM-B model 

      Mantzourani, E.; James, D.H.; Akthar, M.A.; Brown, S.L.; Yemm, R.; Lehnbom, Elin Christina; Hanrahan, J.R.; Seage, C.H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-08)
      Background: Pharmacy professionals are well-placed to provide medication adherence support to patients. The Capability, Opportunity, Motivation-Behaviour (COM–B) and Theoretical Domains Framework (TDF) are two complementary models previously applied to medication-taking behaviour. Understanding the patient-specific barriers and facilitators to adherence using psychological frameworks from the ...

    • Experiences of people living with HIV in low- and middle-income countries and their perspectives in self-management: a meta-synthesis 

      Dadi, Tegene Legese; Wiemers, Anja M. C.; Tegene, Yadessa; Medhin, Girmay; Spigt, Marcus (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-31)
      Introduction Availability of anti-retroviral treatment has changed HIV in to a manageable chronic disease, making efective self-management essential. However, only a few studies in low- and middle-income countries (LMICs) reported experiences of people living with HIV (PLWH) on self-management.<p> <p>Methods This meta-synthesis of qualitative studies investigated perspectives of PLWH in LMICs on ...

    • Whole genome sequencing of recombinant viruses obtained from co-infection and superinfection of Vero cells with modified vaccinia virus ankara vectored influenza vaccine and a naturally occurring cowpox virus 

      Diaz Canova, Diana Karina; Moens, Ugo; Brinkmann, Annika; Nitsche, Andreas; Okeke, malachy ifeanyi (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-03)
      Modified vaccinia virus Ankara (MVA) has been widely tested in clinical trials as recombinant vector vaccine against infectious diseases and cancers in humans and animals. However, one biosafety concern about the use of MVA vectored vaccine is the potential for MVA to recombine with naturally occurring orthopoxviruses in cells and hosts in which it multiplies poorly and, therefore, producing ...

    • Diagnostic flow for all patients referred with non-specific symptoms of cancer to a diagnostic centre in Denmark: A descriptive study 

      Damhus, Christina Sadolin; Brodersen, John; Nielsen, Gunnar Lauge (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-05)
      Background: Since 2012, Cancer Patient Pathways for Non-specific Symptoms and Signs of Cancer (NSSC-CPP) have been implemented in Scandinavia and UK.<p> <p>Objectives: This study aimed to describe the diagnostic flow for all patients referred from 1 January to 30 June 2020 to the NSSC-CPP in the Diagnostic Centre in Farsø (DC-F), Denmark. Methods: During the study period, we prospectively recorded ...

    • Machine Learning Models for Predicting Disability and Pain Following Lumbar Disc Herniation Surgery 

      Berg, Bjørnar; Gorosito, Martin A.; Fjeld, Olaf; Haugerud, Hårek; Storheim, Kjersti; Solberg, Tore K.; Grotle, Margreth (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-07)
      IMPORTANCE Lumber disc herniation surgery can reduce pain and disability. However, a sizable minority of individuals experience minimal benefit, necessitating the development of accurate prediction models.<p> <p>OBJECTIVE To develop and validate prediction models for disability and pain 12 months after lumbar disc herniation surgery. <p>DESIGN, SETTING, AND PARTICIPANTS A prospective, multicenter, ...

    • Thrombolytic Treatment in Wake-Up Stroke: A Propensity Score-Matched Analysis of Treatment Effectiveness in the Norwegian Stroke Registry 

      Søyland, Mary-Helen; Tveiten, Arnstein; Agnethe, Eltoft; Øygarden, Halvor; Varmdal, Torunn; Indredavik, Bent; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-31)
      BACKGROUND: Previous clinical trials found improved outcome of thrombolytic treatment in patients with ischemic wake-up stroke (WUS) selected by advanced imaging techniques. The authors assessed the effectiveness of thrombolytic treatment in patients with WUS in a nationwide stroke registry.<p> <p>METHODS AND RESULTS: Using propensity score matching, the authors assessed the effectiveness and ...

    • ‘There’s a will, but not a way’: Norwegian GPs’ experiences of collaboration with child welfare services – a grounded theory study 

      Øverhaug, Oda Martine Steinsdatter; Laue, Johanna; Vis, Svein Arild Myhra; Risør, Mette Bech (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-24)
      Background Adverse childhood experiences can have immediate effects on a child’s wellbeing and health and may also result in disorders and illness in adult life. General practitioners are in a good position to identify and support vulnerable children and parents and to collaborate with other agencies such as child welfare services. There is a need for better integration of relevant services. ...

    • Gentamicin bør fortsatt inngå i empirisk sepsisregime hos voksne 

      Grønmo, Maria Mellemstrand; Møller-Stray, Janne; Lindemann, Paul Christoffer; Fostervold, Aasmund; Knudsen, Caroline Vestby; Knudsen, Per Kristian; Lindbæk, Morten; Tonby, Kristian; Sundsfjord, Arnfinn Ståle (Journal article; Tidsskriftartikkel, 2024-02-26)
      Kombinasjonen av et smalspektret betalaktamantibiotikum og aminoglykosid bør fortsatt være førstevalg i norske retningslinjer som empirisk antibiotikabehandling av de fleste alvorlige infeksjoner.

    • Body mass index is associated with health-related quality of life and disease characteristics in young adults with juvenile idiopathic arthritis 

      Tuomi, Anna-Kaisa; Rebane, Katariina; Arnstad, Ellen Dalen; Berntson, Lillemor; Fasth, Anders; Glerup, Mia; Herlin, Troels; Kautiainen, Hannu; Nordal, Ellen Berit; Peltoniemi, Suvi; Rygg, Marite; Rypdal, Veronika Gjertsen; Zak, Marek; Aalto, Kristiina (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-02)
      Background There is a growing interest concerning the relationship between obesity and several medical conditions and inflammation. Nevertheless, there is a lack of studies regarding body mass index (BMI) among patients with juvenile idiopathic arthritis (JIA). Our aim was to investigate the impact of BMI on health-related quality of life (HRQoL) measured with a 36-Item Short Form Survey (SF-36), ...