Viser treff 2141-2160 av 10439

    • Prothrombotic Single Nucleotide Polymorphisms and Risk of Myocardial Infarction: A Narrative Review of the Literature 

      Sejrup, Joakim Knutsen (Master thesis; Mastergradsoppgave, 2020-08-24)
      Background: Environmental risk factors for myocardial infarction (MI) have been extensively investigated. In addition, family history of MI is an important risk factor for the disease. Several prothrombotic genotypes are well-established risk factors for venous thrombosis. However, the role of prothrombotic genotypes as risk factors for arterial thrombosis is less emphasized. Aim: To create a ...
    • Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals 

      Howe, Anita Y.M.; Rodrigo, Chaturaka; Cunningham, Evan B.; Douglas, Mark W.; Dietz, Julia; Grebely, Jason; Popping, Stephanie; Sfalcin, Javier Alejandro; Parczewski, Milosz; Sarrazin, Christoph; de Salazar, Adolfo; Fuentes, Ana; Sayan, Murat; Quer, Josep; Kjellin, Midori; Kileng, Hege; Mor, Orna; Lennerstrand, Johan; Fourati, Slim; Di Maio, Velia Chiara; Chulanov, Vladimir; Pawlotsky, Jean-Michel; Harrigan, P. Richard; Ceccherini-Silberstein, Francesca; Garcia, Federico (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-24)
      Background & Aims: Direct-acting antiviral (DAA) regimens provide a cure in >95% of patients with chronic HCV infection. However, in some patients in whom therapy fails, resistance-associated substitutions (RASs) can develop, limiting retreatment options and risking onward resistant virus transmission. In this study, we evaluated RAS prevalence and distribution, including novel NS5A RASs and ...
    • Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway 

      Cook, Sarah; Solbu, Marit Dahl; Eggen, Anne Elise; Iakunchykova, Olena; Averina, Maria; Hopstock, Laila Arnesdatter; Kholmatova, Kamila Kahramonzhonovna; Kudryavtsev, Alexander V; Leon, David A.; Malyutina, Sofia; Ryabikov, Andrew; Williamson, Elizabeth; Nitsch, Dorothea (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-14)
      Background - Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD.<p> <p>Methods - We compared age- and sex-standardised prevalence of ...
    • Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients 

      Soløy-Nilsen, Hedda; Nygård-Odeh, Kristin; Kristiansen, Magnhild Gangsøy; Brekke, Ole Lars; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Øiesvold, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-03)
      Background - There is evidence that brain-derived neurotropic factor (BDNF) plays a protective role in the brain. Peripheral levels of BDNF correlate with its concentration in the brain. Previous studies have revealed lower serum BDNF levels in patients with mental illnesses. In most studies serum BDNF correlates negatively with psychiatric disorders and disease severity. Most studies in this field ...
    • Epidemiology of comorbid hazardous alcohol use and insomnia in 19 185 women and men attending the population-based Tromsø Study 2015–2016 

      Husberg, Vendela; Hopstock, Laila Arnesdatter; Friborg, Oddgeir; Rosenvinge, Jan H; Bergvik, Svein; Rognmo, Kamilla (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-27)
      Background - Hazardous alcohol use is known to be comorbid with insomnia problems. The present study examined the prevalence of insomnia and if the odds of insomnia differed between women and men with a hazardous alcohol use.<p> <p>Methods - Cross-sectional data from the seventh survey of the Norwegian population-based Tromsø Study 2015–2016 (participation 65%). The sample included 19 185 women ...
    • Complementary and alternative medicine modalities used to treat adverse effects of anti‑cancer treatment among children and young adults: a systematic review and meta‑analysis of randomized controlled trials 

      Mora, Dana Catalina; Overvåg, Grete; Jong, Miek; Kristoffersen, Agnete Egilsdatter; Stavleu, Debbie C.; Liu, J Ping; Stub, Trine (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-02)
      Background - Dealing with the symptom burden of cancer diagnosis and treatment has led parents to seek different self-management strategies including Alternative and Complementary Medicine (CAM). The aim of this study was to perform a systematic review and meta-analysis about the use and effect of CAM modalities to treat adverse effects of conventional cancer treatment among children and young ...
    • Talking together in rural palliative care: a qualitative study of interprofessional collaboration in Norway 

      Johansen, May-Lill; Ervik, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-07)
      Background - Caring for people with palliative care needs in their homes requires close collaboration within and between primary and hospital care. However, such close collaboration is often lacking. Transitions of care are potentially unsafe and distressing points in a patient trajectory. Few studies have explored the experiences of healthcare professionals in the community who receive patients ...
    • Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis 

      Bouras, Emmanouil; Karhunen, Ville; Gill, Dipender; Huang, Jian; Haycock, Philip C.; Gunter, Marc J.; Johansson, Mattias; Brennan, Paul; Key, Tim; Lewis, Sarah J.; Martin, Richard M.; Murphy, Neil; Platz, Elizabeth A.; Travis, Ruth; Yarmolinsky, James; Zuber, Verena; Martin, Paul; Katsoulis, Michail; Freisling, Heinz; Nøst, Therese Haugdahl; Schulze, Matthias B.; Dossus, Laure; Hung, Rayjean J.; Amos, Christopher I.; Ahola-Olli, Ari; Palaniswamy, Saranya; Männikkö, Minna; Auvinen, Juha; Herzig, Karl-Heinz; Keinänen-Kiukaanniemi, Sirkka; Lehtimäki, Terho; Salomaa, Veikko; Raitakari, Olli; Salmi, Marko; Jalkanen, Sirpa; Jarvelin, Marjo-Riitta; Dehghan, Abbas; Tsilidis, Konstantinos K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-11)
      Background - Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomisation (MR) ...
    • Socioeconomic inequalities in physiological risk biomarkers and the role of lifestyles among Russians aged 35-69 years 

      Trias-Llimós, Sergi; Cook, Sarah; Eggen, Anne Elise; Kudryavtsev, Alexander V; Malyutina, Sofia; Shkolnikov, Vladimir M.; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-15)
      Background: Socioeconomic inequalities in cardiovascular (CVD) health outcomes are well documented. While Russia has one of the highest levels of CVD mortality in the world, the literature on contemporary socio-economic inequalities in biomarker CVD risk factors is sparse. This paper aims to assess the extent and the direction of SEP inequalities in established physiological CVD risk biomarkers, ...
    • Risk factors of anemia among preschool children in Ethiopia: a Bayesian geo-statistical model 

      Endris, Bilal Shikur; Dinant, Geert-Jan; Hagos, Seifu; Spigt, Marcus (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-07)
      Background - The etiology and risk factors of anemia are multifactorial and varies across context. Due to the geospatial clustering of anemia, identifying risk factors for anemia should account for the geographic variability. Failure to adjust for spatial dependence whilst identifying risk factors of anemia could give spurious association. We aimed to identify risk factors of anemia using a Bayesian ...
    • Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study 

      Linkas, Jonas; Ahmed, Luai A.; Csifcsak, Gabor; Emaus, Nina; Furberg, Anne-Sofie; Grimnes, Guri; Pettersen, Gunn; Rognmo, Kamilla; Christoffersen, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-15)
      Background - Inflammatory markers have been associated with depression and anxiety disorder in adolescents. Less is known about the association between inflammation and subclinical symptoms in the form of psychological distress. We investigated prevalence of psychological distress and examined the associations between common pro-inflammatory markers and psychological distress in an adolescent ...
    • Is amalgam removal in patients with medically unexplained physical symptoms cost-effective? A prospective cohort and modelling study in Norway 

      Lamu, Admassu Nadew; Björkman, Lars; Hamre, Harald Johan; Alræk, Terje; Musial, Frauke; Robberstad, Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-29)
      There are many patients in general practice with health complaints that cannot be medically explained. Some of these patients attribute their health complaints to dental amalgam restorations. This study examined the cost-effectiveness of the removal of amalgam restorations in patients with medically unexplained physical symptoms (MUPS) attributed to amalgam fillings compared to usual care, based ...
    • Association between cannabis use and physical health problems in Norwegian adolescents: a cross-sectional study from the youth survey Ungdata 

      Mæland, Ragnhild; Lien, Lars; Leonhardt, Marja (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-06)
      Background - Cannabis use is increasing among young Norwegians and several studies show a high incidence of common physical health problems. An association has previously been found between cannabis use and mental health problems. Since physical and mental health problems often co-occur, the aim of this study is to explore the relationship between cannabis use and physical health problems.<p> <p>Methods ...
    • From fixed-dried to wet-fixed to live-comparative super-resolution microscopy of liver sinusoidal endothelial cell fenestrations 

      Szafranska, Karolina; Neuman, Tanja; Baster, Zbigniew; Rajfur, Zenon; Szelest, Oskar; Holte, Christopher Florian; Kubisiak, Agata; Kus, Edyta; Wolfson, Deanna; Chlopicki, Stefan; Ahluwalia, Balpreet Singh; Lekka, Malgorzata; Szymonski, Marek; McCourt, Peter Anthony; Zapotoczny, Barlomiej (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-20)
      Fenestrations in liver sinusoidal endothelial cells (LSEC) are transcellular nanopores of 50–350 nm diameter that facilitate bidirectional transport of solutes and macromolecules between the bloodstream and the parenchyma of the liver. Liver diseases, ageing, and various substances such as nicotine or ethanol can negatively influence LSECs fenestrations and lead to defenestration. Over the years, ...
    • Norwegian Open Fracture Management System: Outcomes after 10 Years Working in Low-Resource Settings in Cambodian Hospitals 

      Tajsic, Nenad; Sørbye, Sigrunn Holbek; Nguon, Sophy; Sokh, Vannara; Lim, Aymeric (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-13)
      Introduction: The treatment of open lower limb fractures represents a major challenge for any trauma surgeon, and this even more so in resource-limited areas. The aim of the study is to describe the intervention, report the treatment plan, and observe the effectiveness of the Norwegian Open Fracture Management System in saving lower limbs in rural settings.<p> <p>Materials and Methods: A ...
    • Disassembly and Mislocalization of AQP4 in Incipient Scar Formation after Experimental Stroke 

      Banitalebi, Shervin; Skauli, Nadia; Geiseler, Samuel; Ottersen, Ole Petter; Amiry-Moghaddam, Mahmood (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-20)
      There is an urgent need to better understand the mechanisms involved in scar formation in the brain. It is well known that astrocytes are critically engaged in this process. Here, we analyze incipient scar formation one week after a discrete ischemic insult to the cerebral cortex. We show that the infarct border zone is characterized by pronounced changes in the organization and subcellular ...
    • AXL inhibition improves BRAF-targeted treatment in melanoma 

      Nyakas, Marta Sølvi; Fleten, Karianne Giller; Haugen, Mads Haugland; Engedal, Nikolai; Sveen, Christina; Farstad, Inger Nina; Flørenes, Vivi Ann; Prasmickaite, Lina; Mælandsmo, Gunhild Mari; Vasiliauskaite, Kotryna (Journal article; Tidsskriftartikkel; Peer reviewed, 2022)
      More than half of metastatic melanoma patients receiving standard therapy fail to achieve a long-term survival due to primary and/or acquired resistance. Tumor cell ability to switch from epithelial to a more aggressive mesenchymal phenotype, attributed with AXL<sup>high</sup> molecular profle in melanoma, has been recently linked to such event, limiting treatment efcacy. In the current study, ...
    • Conventional health care service utilization among cancer survivors that visit traditional and complementary providers in the Tromsø study: a cross-sectional study 

      Nakandi, Kiwumulo; Mora, Dana Catalina; Stub, Trine; Kristoffersen, Agnete Egilsdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-11)
      Background: Traditional and complementary medicine (T&CM) is commonly used among cancer patients worldwide. Cancer patients in Norway mainly visit T&CM providers in addition to conventional health care services. It is not known how their utilization of T&CM providers influences their use of conventional health care services. The aim of this study was to investigate the difference between the ...
    • Perceptions of the academic learning environment among occupational therapy students – changes across a three-year undergraduate study program 

      Stigen, Linda; Mørk, Gry; Carstensen, Tove; Magne, Trine A; Gramstad, Astrid; Johnson, Susanne Grødem; Småstuen, Milada Cvancarova; Bonsaksen, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-25)
      Introduction: Although the learning environment influences students’ motivation, learning outcomes, and satisfaction with the study program, less is known about how these factors change as the students’ progress through the study program.<p> <p>Aim: The aim of this study was to examine changes in occupational therapy students’ perceptions of the academic learning environment during their three-year ...
    • Self-reported mental health status of pregnant women in Sweden during the COVID-19 pandemic: a cross-sectional survey 

      Ho-Fung, Chung; Andersson, Ewa; Hsuan-Ying, Huang; Acharya, Ganesh; Schwank, Simone (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-28)
      Background: The COVID-19 pandemic has contributed to unprecedented worries and challenges for pregnant women due to social restrictions and changes in maternity care provision. We aimed to investigate the mental health impact of COVID-19 pandemic on pregnant women in Sweden and explore factors associated with poor perinatal mental health in this specifc context.<p> <p>Method: This was a nation-wide ...