Legumain is known to be regulated in atherosclerotic disease and may have both pro- and anti-atherogenic properties. The study aimed to explore legumain in individuals with familial hypercholesterolemia (FH), a population with increased cardiovascular risk. Plasma legumain was measured in 251 subjects with mostly genetically verified FH, of which 166 were adults (≥18 years) and 85 were children and ...

Background - Maintaining quality of life (QoL) and identifying contributing factors is an important aspect of treatment for glioma patients. Little is known about to what extent language function and psychological distress impact QoL before surgery.<p> <p>Aims - The aim of the present study was to investigate the impact of subjective and objective language function, as well as psychological ...

Between the sixth and ffteenth c. CE, a vast expanse of central and southern Sudan belonged to the kingdom of Alwa, ruled from the urban metropolis of Soba. Renewed investigation of the city unearthed a small cemetery in the northern part of the site. The heterogeneity of burial practices raised some questions as to the cultural and religious afnities of the deceased and suggested potential ...

Introduction Cardiac organ damage like left ventricular (LV) hypertrophy and left atrial (LA) enlargement is more prevalent in women than men with hypertension, but the mechanisms underlying this gender difference remain unclear.<p> <p>Methods We tested the association of drug nonadherence with the presence of LV hypertrophy and LA enlargement by echocardiography in 186 women and 337 men with ...

BACKGROUND - Drug concentration in blood or urine is an acknowledged method to detect nonadherence. Observational studies suggest that informing patients about low or absent serum drug levels improves blood pressure (BP). We performed a multicenter randomized clinical trial to test the hypothesis that therapeutic drug monitoring (TDM) could improve drug adherence and BP in patients with uncontrolled ...

Background: Approximately 15 million children are born each year prematurely, representing more than 10 percent of all childbirths worldwide. Prematurity is an acute event and the leading cause of death among newborns and children under five. Sixty percent of these premature deaths occur in Sub-Saharan Africa and Southeast Asia.<p> <p>Objective: The current study aimed to explore and understand ...

Today, issues related to people’s mental health and well-being have been described as a challenge for society, globally as well as in Sweden. This calls for new approaches to mental health promotion. The aim was to evaluate the adequacy of its content and structure, describing experiences of study circles as a means of supporting participants’ self-care and self-compassion. The overall design is a ...

After the sudden and violent death of a loved one, many bereaved experience symptoms of prolonged grief (PG) and posttraumatic stress (PTS). The present study investigated the cross-sectional and longitudinal associations of grief-related rumination with PG and PTS symptoms among bereaved parents and siblings after the Utøya terror attack in Norway on 22 July 2011 (N = 110, M_age = 43.2 years, ...

Several studies have noted that the International Seabed Authority (ISA) scores low on public participation. However, none have studied the efforts of non-governmental organizations to exert influence on the ISA’s rulemaking processes. I examine how environmental NGOs and private mining contractors attempt to sway one narrow, but existential, part of the ISA’s draft exploitation regulations between ...

Purpose Group B streptococcus (GBS) colonizes the gastrointestinal and vaginal mucosa in healthy adults, but has also become an increasing cause of invasive infection. The aims of this study were to describe the incidence and factors associated with the occurrence of invasive GBS disease in adults in Norway. Methods We performed a nationwide retrospective case–control study of invasive GBS infections ...