The p38 MAPK is a signaling pathway important for cells to respond to environmental and intracellular stress. Upon activation, the p38 kinase phosphorylates downstream effectors, which control the inflammatory response and coordinate fundamental cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of this signaling pathway has been linked to inflammatory diseases ...

Medikamentell behandling av epilepsi er oftest både livsviktig og livslang, derfor er god etterlevelse av behandlingen viktig for god sykdomskontroll. På bakgrunn av dette kan man dermed anta at dårlig etterlevelse er en vanlig årsak til anfallsgjennombrudd ved epilepsi, som igjen kan ha sammenheng med informasjonen pasienter får om sine legemidler Den overordnede hensikten med studien var å utvikle ...

Background: As antibiotic resistance creates a signifcant global health threat, we need not only to accelerate the development of novel antibiotics but also to develop better treatment strategies using existing drugs to improve their efcacy and prevent the selection of further resistance. We require new tools to rationally design dosing regimens from data collected in early phases of antibiotic ...

The beginning of the 21st century saw numerous protein and peptide therapeuticals both on the market and entering the final stages of clinical studies. They represent a new category of biologically originated drugs termed biologics or biologicals. Their main advantages over conventional drugs can be summarized by their high selectivity and potent therapeutic efficacy coupled with limited side ...

Background and Aims: Low-dose naltrexone [LDN] is a controversial off-label treatment used by many Crohn’s disease [CD] and ulcerative colitis [UC] patients. A small number of preliminary studies indicate that LDN might be beneficial in CD, but evidence is too scarce to demonstrate efficacy. We sought to examine whether initiation of LDN therapy by patients with inflammatory bowel disease [IBD] ...

Dehydrochloromethyltestosterone (DHCMT) is one of the most detected illicit used anabolic–androgenic steroids in professional sports. Therefore, a fast and accurate analysis of this substance is of great importance for a constructive fight against doping abuse. The conventional method for the analysis of this drug, GC-MSMS, is very sensitive and selective but also very time- and resource-consuming. ...

<b><p>Background</b> Antibiotic self-medication is common in low- and middle-income countries. This study aimed to evaluate the Sri Lankan public’s knowledge about and attitudes toward antibiotic use and self-medication, and factors associated with self-medication. <b><p>Methods</b> A national cross-sectional, interviewer-administered, survey of a random household sample (N = 1100) was ...

<p><i>Hensikt: </i>Å kartlegge apotekkunders erfaring med og vilje til å ta influensavaksine, samt utvalgte faktorers sammenheng med ­vaksineringsvilje, inkludert sannsynlighet for å ta covid-19-vaksine. <p><i>Materiale og metode: </i>Masterstudenter i apotekpraksis intervjuet apotekkunder ved hjelp av spørreskjema. Spørsmålene omfattet erfaring med influensavaksine, risikogruppestatus, vaksineringsvilje, ...

Introduction: The ‘emergency department (ED) pharmacist’ is an integrated part of the ED interdisciplinary team in many countries, which have shown to improve medication safety and reduce costs related to hospitalisations. In Norway, few EDs are equipped with ED pharmacists, and research describing effects on patients has not been conducted. The aim of this study is to investigate the impact ...

It is widely accepted that both comedications and genetic factors may contribute to variation of drug response. Clinical decision support systems increasingly consider recommendations on drug– drug interactions (DDIs) during electronic prescribing, and some guidelines on drug–gene-interactions (DGI) have been implemented in drug labels. Potentially synergistically or antagonistically ...