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Novel Molecular Characteristics of Ulcerative Colitis
(Doctoral thesis; Doktorgradsavhandling, 2025-01-10)Ulcerative Colitis (UC) is a chronic autoimmune inflammatory disease and one type of inflammatory bowel disease (IBD). UC is characterized by a temporal course of remission and relapse. Environmental factors, immune system dysregulation, and genetic susceptibility interact intricately in the aetiology of UC. It is unclear how interactions involving non-coding RNAs (ncRNAs), epigenetic modifications, ... -
Fordeler og begrensninger med veiledning på digitale flater
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-21)På grunn av koronapandemien og økt digitalisering i samfunnet, har digital veiledning fått mer oppmerksomhet. Det er likevel begrenset forskning på fordelene og utfordringene ved å flytte veiledning til digitale plattformer. Studien undersøker veilederes erfaringer med digital veiledning gjennom en spørreundersøkelse. Fordeler ved veiledning på digitale flater var hovedsakelig knyttet til praktiske ... -
Ability of clinical data to predict readmission in Child and Adolescent Mental Health Services
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-18)This study addresses the challenge of predicting readmissions in Child and Adolescent Mental Health Services (CAMHS) by analyzing the predictability of readmissions over short, medium, and long term periods. Using health records spanning 35 years, which included 22,643 patients and 30,938 episodes of care, we focused on the episode of care as a central unit, defined as a referral-discharge cycle ... -
The annual trend of suicide rates from 2010 to 2021 in patients with cannabis use disorder – a national registry study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-28)Purpose - The temporal trend of suicide in patients with cannabis use disorder (CUD) is important to investigate, considering the recent increases in THC concentration in cannabis products. This study describes the annual suicide rates in patients with CUD from 2010 to 2021. To investigate if any change in suicide rate was specific to CUD, we compared these suicide rates with corresponding data for ... -
Development of brain metastases in patients managed with non-curative thoracic radiotherapy for stage II/III non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-27)Background - This retrospective study analyzed the incidence of subsequent brain metastases after palliative radiotherapy or chemoradiation in patients with stage II/III non-small cell lung cancer (NSCLC). Risk factors for brain metastases development and survival after diagnosis were evaluated.<p> <p>Methods - Different baseline parameters including but not limited to age, stage and target volume ... -
P314 TNF gene activation used as criterion to discontinue biologic therapy – A patient series introducing the NovaPrime TNF kit
(Conference object; Konferansebidrag, 2021-05-27)<p><i>Background - </i>Severe inflammatory bowel disease can be successfully treated with biologic drugs such as anti-TNF. However, there is no consensus on if and how to stop treatment. Our group has earlier shown that normalization of TNF gene expression may be a beneficial prognostic factor when attempting to discontinue biologic therapy. We here present data from a series of patients in endoscopic ... -
Agreement between child- and parent-reported orofacial symptoms in patients with juvenile idiopathic arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-30)Objective: To assess the agreement between child- and parent-reported orofacial symptoms in the Danish version of the patient questionnaire Assessment of Orofacial Symptoms in Juvenile Idiopathic Arthritis.<p> <p>Method: This cross-sectional study was conducted at Aarhus University in March 2023. Eligible candidates were consecutive subjects with juvenile idiopathic arthritis (JIA) and ... -
The proportion and utilisation of formal kinship and network care in Norway and Denmark: a comparative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-20)In the past decades, the implementation of regulations and legislation, which encourage the use of formal kinship and network care, has taken place in many countries. Yet, the proportion seems to vary greatly, also between countries often regarded as similar. Denmark and Norway are examples of this. In 2021, 33% of children in care lived in kinship and network care compared to 13% in ... -
Patient-reported outcomes after treatment for rectal cancer—A prospective nationwide study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-08)Aim - While modern treatment has improved rectal cancer (RC) survival, it can cause late side effects that impact health-related quality of life (HRQoL). The aim of this study was to evaluate HRQoL and late effects 1 year after diagnosis in patients who underwent major resection for Stage I–III RC.<p> <p>Method - All patients with RC registered in the Cancer Registry of Norway between 1 January ... -
Construct Validity of the Orientation to Life Questionnaire in a General Adult Population in Norway and Its Association with Self-Reported General and Oral Health
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-17)Objective - Individuals' Sense of Coherence (SOC) is measured with the Orientation to Life Questionnaire (OLQ-13). SOC reflects a person's orientation to life and ability to manage stress, which can impact health. The aim of the study was to test the reliability and construct validity of the OLQ-13, with self-reported general and oral health as criterion measures, in a Norwegian general adult ... -
Alcohol and cause-specific mortality in Russia: the Know Your Heart Study 2015–23
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-12)Background - Alcohol-related mortality in Russia exceeds the world average and presents a critical public health concern. This study assesses the impact of alcohol consumption levels on mortality and investigates mortality predictors among Russians, including people treated for alcohol-related diagnoses (narcology patients).<p> <p>Methods - We examined 2629 men and women aged 35–69 years who ... -
Periodontitis and dental quality of life predict long-term survival in head and neck cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-19)Background - Our aim was to investigate oral health in newly diagnosed head and neck squamous cell carcinoma (HNSCC) patients in relation to long-term survival. We assessed whether the level of alveolar bone loss due to periodontitis at diagnosis, measured from orthopantomogram (OPG), and reported dental health-related quality of life (HRQoL) scores obtained at diagnosis contain prognostic information ... -
Ethics in the operating room: a systematic review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-09)Background/Objective - The act of surgery involves harming vulnerable patients with the intent that the results will improve their health and, ultimately, help the patients. Such activities will inevitably entail moral decisions, yet the ethics of surgery has only recently developed as a field of medical ethics. Within this field, it is striking how few accounts there are of actions within the ... -
Transient biopsy-proven progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) in an elderly woman without known immunodeficiency: a case report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-09)Background - Progressive multifocal leukoencephalopathy (PML) is a severe opportunistic brain disease caused by lytic JC polyomavirus (JCPyV) replication in oligodendrocytes. Although JCPyV infection is common in the general population, PML almost exclusively occurs in patients immunocompromised due to untreated HIV/AIDS, haematological malignancies, primary immunodeficiencies, solid organ ... -
DNA methylation classifier to diagnose pancreatic ductal adenocarcinoma metastases from different anatomical sites
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-10)Background - We have recently constructed a DNA methylation classifier that can discriminate between pancreatic ductal adenocarcinoma (PAAD) liver metastasis and intrahepatic cholangiocarcinoma (iCCA) with high accuracy (PAAD-iCCA-Classifier). PAAD is one of the leading causes of cancer of unknown primary and diagnosis is based on exclusion of other malignancies. Therefore, our focus was to investigate ... -
Prescription of benzodiazepines and antidepressants among Sami and non-Sami — How childhood violence shapes prescription patterns: the SAMINOR 2 questionnaire survey and the Norwegian prescription database
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-07)Background - Medication for mental health problems represents a significant proportion of overall medication use and the prescription of psychotropic medicine has increased in many western countries over the last decades. Childhood violence (CV) is strongly associated with mental health problems, which in turn may increase the likelihood of being prescribed psychotropic medication. However, the ... -
Massive entry of BK Polyomavirus induces transient cytoplasmic vacuolization of human renal proximal tubule epithelial cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-21)BK polyomavirus (BKPyV) is a ubiquitous human virus that establishes a persistent infection in renal tubular epithelial cells and mainly causes disease in kidney transplant recipients. The closely related simian polyomavirus SV40 is known to cause cytoplasmic vacuolization in simian kidney cells, possibly increasing progeny release and cell death. This study aimed to determine whether BKPyV causes ... -
Care Convoys and Solitary Vessels: Navigating Family Care for Older Adults Living With Dementia in Arctic Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-09)Drawing on the metaphor of “care convoys,” this study explores the experiences and strategies of family caregivers of older adults with dementia in rural areas of Northern Norway. The study is part of a broader project that investigates how these older adults and their caregivers use or do not use municipal health and care services. We conducted qualitative in-depth interviews with 11 family caregivers ... -
Impact of B7-H3 expression on metastasis, immune exhaustion and JAK/STAT and PI3K/AKT pathways in clear cell renal cell carcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-01)Immune checkpoint inhibitors in combination with tyrosine kinase inhibitors (TKIs) are improving the response rates of advanced renal cancer patients. However, many treated patients do not respond, making novel immune checkpoint-based immunotherapies potentially clinically beneficial only for specific groups of patients. We detected high expression of the immune checkpoint protein B7-H3 in clear ... -
Challenges and Strategies in Nursing Leadership: A Qualitative Study on Leaders in Mental Health Care
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-10)Aim: To explore the challenges and strategies among new and experienced nursing leaders in mental healthcare; furthermore, to identify factors that support or hinder their leadership roles. Background: Strong nursing leadership is crucial for the quality of patient care and is associated with higher job security and better patient outcomes. Understanding what factors contribute to effective leadership ...
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