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The annual trend of suicide rates from 2010 to 2021 in patients with cannabis use disorder – a national registry study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-28)Purpose - The temporal trend of suicide in patients with cannabis use disorder (CUD) is important to investigate, considering the recent increases in THC concentration in cannabis products. This study describes the annual suicide rates in patients with CUD from 2010 to 2021. To investigate if any change in suicide rate was specific to CUD, we compared these suicide rates with corresponding data for ... -
Development of brain metastases in patients managed with non-curative thoracic radiotherapy for stage II/III non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-27)Background - This retrospective study analyzed the incidence of subsequent brain metastases after palliative radiotherapy or chemoradiation in patients with stage II/III non-small cell lung cancer (NSCLC). Risk factors for brain metastases development and survival after diagnosis were evaluated.<p> <p>Methods - Different baseline parameters including but not limited to age, stage and target volume ... -
P314 TNF gene activation used as criterion to discontinue biologic therapy – A patient series introducing the NovaPrime TNF kit
(Conference object; Konferansebidrag, 2021-05-27)<p><i>Background - </i>Severe inflammatory bowel disease can be successfully treated with biologic drugs such as anti-TNF. However, there is no consensus on if and how to stop treatment. Our group has earlier shown that normalization of TNF gene expression may be a beneficial prognostic factor when attempting to discontinue biologic therapy. We here present data from a series of patients in endoscopic ... -
Agreement between child- and parent-reported orofacial symptoms in patients with juvenile idiopathic arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-30)Objective: To assess the agreement between child- and parent-reported orofacial symptoms in the Danish version of the patient questionnaire Assessment of Orofacial Symptoms in Juvenile Idiopathic Arthritis.<p> <p>Method: This cross-sectional study was conducted at Aarhus University in March 2023. Eligible candidates were consecutive subjects with juvenile idiopathic arthritis (JIA) and ... -
Patient-reported outcomes after treatment for rectal cancer—A prospective nationwide study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-08)Aim - While modern treatment has improved rectal cancer (RC) survival, it can cause late side effects that impact health-related quality of life (HRQoL). The aim of this study was to evaluate HRQoL and late effects 1 year after diagnosis in patients who underwent major resection for Stage I–III RC.<p> <p>Method - All patients with RC registered in the Cancer Registry of Norway between 1 January ... -
Ethics in the operating room: a systematic review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-09)Background/Objective - The act of surgery involves harming vulnerable patients with the intent that the results will improve their health and, ultimately, help the patients. Such activities will inevitably entail moral decisions, yet the ethics of surgery has only recently developed as a field of medical ethics. Within this field, it is striking how few accounts there are of actions within the ... -
Transient biopsy-proven progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) in an elderly woman without known immunodeficiency: a case report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-09)Background - Progressive multifocal leukoencephalopathy (PML) is a severe opportunistic brain disease caused by lytic JC polyomavirus (JCPyV) replication in oligodendrocytes. Although JCPyV infection is common in the general population, PML almost exclusively occurs in patients immunocompromised due to untreated HIV/AIDS, haematological malignancies, primary immunodeficiencies, solid organ ... -
Massive entry of BK Polyomavirus induces transient cytoplasmic vacuolization of human renal proximal tubule epithelial cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-21)BK polyomavirus (BKPyV) is a ubiquitous human virus that establishes a persistent infection in renal tubular epithelial cells and mainly causes disease in kidney transplant recipients. The closely related simian polyomavirus SV40 is known to cause cytoplasmic vacuolization in simian kidney cells, possibly increasing progeny release and cell death. This study aimed to determine whether BKPyV causes ... -
Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-02)In clinical practice, the glomerular filtration rate (GFR), a measurement of kidney functioning, is normally calculated using equations, such as the European Kidney Function Consortium (EKFC) equation. Despite being the most general equation, EKFC, just like previously proposed approaches, can still struggle to achieve satisfactory performance, limiting its clinical applicability. As a possible ... -
Timely empirical antibiotic therapy against sepsis in a rural Norwegian ambulance service: a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-31)Background Early diagnosis and antibiotic therapy in patients with sepsis reduce morbidity and mortality, thus pre-hospital management is likely to affect patient outcomes. Pre-hospital administration may increase the risk of unnecessary use of broad-spectrum antibiotics, but identification of an infectious focus enables more targeted antibiotic therapy. The aim of this study was to investigate ... -
The patient’s voice: a cross-sectional study of physical health and disability in juvenile idiopathic arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-18)Background With increasing focus on patient-reported outcome measures (PROMs) in chronic rheumatic diseases, we aimed to evaluate the self-reported physical and psychosocial health in children with juvenile idiopathic arthritis (JIA) compared to matched population-based controls. Furthermore, we aimed to study the association of patient and physician-reported outcome measures in JIA with ... -
PFAS exposure is associated with an unfavourable metabolic profile in infants six months of age
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-01)Exposure to perfluoroalkyl substances (PFAS) are reported to have numerous negative health effects and children are especially vulnerable. The aim of this study was to investigate whether maternal and infant PFAS burden have any impact on prenatal and postnatal growth, liver and lipid parameters in infants at age six months. Data on diet and growth parameters, as well as blood samples were collected ... -
Exploring the unconventional: health professionals’ experiences into medication-free treatment for patients with severe mental illness
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-14)Background In January 2017, the Norwegian government mandated the establishment of an inpatient unit for“medication-free treatment” for patients with severe mental illness at the University Hospital of North Norway in Tromsø. This study aims to explore the employees’ experiences with this unit.<p> <p>Method Focus group interviews were conducted October 2021 – February 2022. For analysis, the ... -
Stereotactic radiotherapy for patients with bone metastases: a selected group with low rate of radiation treatment during the last month of life?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-01)Background - Complex high-precision radiotherapy, such as stereotactic body radiotherapy (SBRT), should only be offered to patients with sufficiently long survival. In the context of bone metastases radiotherapy, low rates of treatment close to the end of life, e.g. last 30 days (RT30), may serve as a quality of care indicator. While traditional, pain-relieving short-course regimens have been studied ... -
The prevalence of subdural blood products in extremely premature infants with no history of abusive head trauma, studied by magnetic resonance imaging around term-equivalent age
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-14)Background Prematurity and enlarged subarachnoid spaces are both hypothesised to represent an increased risk of subdural haemorrhages (SDHs) in infancy, both with and without a history of abuse.<p> <p>Objective To examine the prevalence of a previous haemorrhage, particularly SDHs, in infants born extremely prematurely around term-equivalent age; to examine intra- and inter-observer agreement ... -
A randomized trial on three different minimally invasive decompression techniques for lumbar spinal stenosis. Five years follow-up from the NORDSTEN-SST
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-24)Purpose The short-term clinical outcome for midline-preserving posterior decompression techniques was comparable. The aim of this study was to evaluate long-term clinical results after three different midline-preserving posterior decompression techniques.<p> <p>Material In the NORDSTEN spinal stenosis trial (NORDSTEN-SST) 437 patients were randomized to three different midline-retaining ... -
Prisforedrag - Norsk Cardiologisk Selskaps forskningspris 2023
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024)Det var en stor ære for meg å motta forskningsprisen. Jeg er takknemlig, ydmyk og stolt overfor Norsk cardiologisk selskap (NCS) og juryen. Få fra miljøet i Tromsø har mottatt prisen, og innenfor fagområdet preventiv kardiologi er det heller ikke mange prismottakere. Jeg ble veldig glad. Det var en stor begivenhet for meg å bli hyllet av mine kolleger, både fra min egen hjertemedisinske avdeling og ... -
Factors Associated With Prescription of Systemic Therapy in Real-world Patients With Metastatic Renal Cell Cancer Managed in a Rural Region
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-05-03)Background/Aim: Numerous new treatment options have been approved for metastatic renal cell carcinoma (mRCC) in the last decade. Nevertheless, not all patients receive systemic therapy. Certain patients present with very advanced disease, poor Eastern Cooperative Oncology Group performance status (ECOG PS), or severe comorbidity, i.e. factors that lead oncologists to prefer best supportive ... -
Is smokeless tobacco a healthier option in patients with AUD? A follow-up study during treatment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-20)Introduction - Smoking is negatively related to mental health, but there is a paucity of research on the relationship between the use of smokeless tobacco, such as snus, and mental health outcomes, especially in people with alcohol use disorders (AUD). The aim of the present study was to examine the development of mental distress and quality of life (QoL) among AUD patients in treatment who did or ... -
Genetics of hip dysplasia - a systematic literature review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-01)Background - Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2–3% of all newborns. DDH increases the risk of osteoarthritis and is the cause of 30% of all total hip arthroplasties in adults < 40 years of age. We aim to explore the genetic background of DDH in order to improve diagnosis and personalize treatment.<p> <p>Methods - We conducted a structured literature ...
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