Institutt for farmasi: Recent submissions

Now showing items 541-560 of 656

    • Identifisering av PAX- og MMP-uttrykk i tre prostatakreft-cellelinjer 

      Weibust, Elisabeth (Master thesis; Mastergradsoppgave, 2009-05-20)
      Invasjon og metastasering er den vanligste årsaken til død hos kreftpasienter og dermed et alvorlig klinisk problem. Det er derfor viktig å forske på dette området for å finne mekanismene bak disse prosessene. Matriks metalloproteinaser (MMPer) er overuttrykt i flere kreftformer. PAX6 er en transkripsjonsfaktor som er vist å regulere matriks metalloproteinase 2 og 9 (MMP-2 og MMP-9) i henholdsvis ...

    • Isolation and characterization of antiviral compounds from marine organisms 

      Ammari, Yashar (Master thesis; Mastergradsoppgave, 2010-06-16)
      Metridium senile, Halocynthia pyriformis and ParaParastichopus tremulus were subjected to organic and aqueous extraction. The aqueous extract was made with water, while the organic was made with dichloromethane and methanol in 1:1 ratio. The aqueous and organic extracts were fractionated on reversed-phase HPLC and tested for antiviral activity against Herpes simplex virus-1. All the three organisms ...

    • Isolation and characterization of antibacterial compounds from marine organisms 

      Thanki, Meera Satish (Master thesis; Mastergradsoppgave, 2010-06-17)
      Marine bioprospecting is a promising field of research that has gained interest worldwide for the past few decades, and can be characterised as a systematic and purpose oriented search for bioactive compounds or genetic material from marine sources. Several compounds have been isolated and some have found their way into the commercial market. The main aim of this master thesis was to investigate the ...

    • Ampicillin resistance and bacterial diversity in colon content from grey seals (Halichoerus grypus) and harbour seals (Phoca vitulina) at the coast of Northern Norway 

      Kristiansen, Vibeke Fam (Master thesis; Mastergradsoppgave, 2007-05)
      Very little is known on the gut microbial ecology in seals. Environmental populations of bacteria, like those found in the gut of wildlife presumably unexposed to human antibiotic use, may be a reservoir of clinically important resistance genes. The purpose of this study was to characterize the bacterial diversity in the colon of grey seals (Halichoerus grypus) and harbour seals (Phoca vitulina) at ...

    • Lipidklasser og fettsyresammensetning i omega-3 produkter 

      Eriksen, Sureeporn Aemsangthum (Master thesis; Mastergradsoppgave, 2012-05-20)
      Nasjonalt råd for ernæring anbefaler å spise fisk og sjømat fordi de innholder de flerumettede omega-3 fettsyrene eikosapentaensyre (EPA: 20:5n-3) og dokosahekaensyre (DHA: 22: 6n-3). Mye forskning viser kobling mellom omega-3 fettsyrene og helsegevinster. Helsegevinstene er at disse fettsyrene er betennelsesdempende, de reduserer risiko for å utvikle sykdommer som revmatoid artritt, hjerte -kar ...

    • Isolation and characterization of anti-inflammatory compounds from marine organisms : Eucratea loricata and Echinus esculentus 

      Do, Minh-Anh Thuy (Master thesis; Mastergradsoppgave, 2012-05-19)
      In the last decade, the investigation of marine natural products has resulted in a remarkable number of compounds with promising biological activities. Marine natural products have been shown to display antibacterial, antifungal, anticancer, antiviral, antiparasitic, anti-inflammatory activity and several other pharmacological activities of benefit to humankind. In this project, an investigation ...

    • Evaluation of a pharmacist-led cardiovascular risk clinic for patients with diabetes attending a hospital out-patient clinic 

      Majid Alwan, Ahmed (Master thesis; Mastergradsoppgave, 2012-06-11)
      Cardiovascular disease is strongly associated with diabetes; hypertension is prominent in diabetic patients. In 2003 a pharmacist-led cardiovascular risk reduction clinic was established to reduce cardiovascular risk in diabetic patients. The aim of this study was to evaluate the feasibility of outcome measures to inform a future prospective study to evaluate the pharmacist-led clinic and to ...

    • Development of bioactive peptides from the parasitic hookworm as potential treatments for autoimmune diseases 

      Baumann, Markus (Master thesis; Mastergradsoppgave, 2012-06)
      Hookworms are parasitic nematodes that reside in the intestines of their host, where they feed on host blood. The large number of infected individuals and the long survival time inside the host makes it interesting to study the immunomodulatory activities of the hookworms. The excretory/secretory (ES) products are suspected to be responsible for these effects. One aim of this project was to fractionate ...

    • Review and development of referral criteria used to identify patients with diabetes who would benefit from attending a pharmacist-led cardiovascular out-patient clinic 

      Westerhus, Ingvild Risan (Master thesis; Mastergradsoppgave, 2012-05)
      Abstract Development and validation of new referral criteria: a triangulation study at the Pharmacist-led Diabetes Cardiovascular risk Reduction Clinic, Edinburgh. The Pharmacist-led Diabetes Cardiovascular risk Reduction (DCVR) clinic has been running at the Western General Hospital (WGH), Edinburgh, for 8 years. It was decided to review the referral process of patients and the referral criteria. ...

    • LC-MS basert analysemetode av gentamicin i blodprøver 

      Haug, Marianne Helene Christiansen (Master thesis; Mastergradsoppgave, 2012-05-20)
      Gentamicin er hyppig brukt til å behandle alvorlige infeksjoner, men kan ved langvarig behandling eller ved høy serumkonsentrasjon gi vevsskade i både nyrer og ører. Måling av serumkonsentrasjonen skjer rutinemessig med en immunologisk metode som krever et blodvolum på 500 µl. Hyppige målinger er i noen tilfeller nødvendig for å få god kontroll på behandlingen. Premature barn har lav kroppsvekt og ...

    • Isolation and characterization of bioactive compounds from the marine hydrozoans Halecium muricatum and Halecium beanii 

      Korsmo, Kim André (Master thesis; Mastergradsoppgave, 2012-05)
      In the marine environment there is a great potential for discovering new commercial drugs, and marine bioprospecting has previously led to the discovery of drugs available for clinical use, like Yondelis ® and cytosine arabinoside. In this work two hydroids were tested for anticancer and antibacterial activity. The organic extracts from the two hydroids, Halecium muricatum and Halecium beanii, ...

    • Fettsyresammensetning og kvalitetsaspekter og kommersielle krilloljeprodukter 

      Vu, Kim Anh Thi (Master thesis; Mastergradsoppgave, 2012-06)
      Krill er rik på omega-3 fettsyrene EPA og DHA, noe som forklarer den store kommersielle interesse for fangst og foredling av krill. I krillolje er det mye fosfolipider sammenliknet med fiskeoljer. Flere hevder at EPA og DHA utnyttes bedre når de er bundet i fosfolipider enn når de fins i triacylglyserol (Bunea et al, 2004; Werner, Havinga et al, 2004). Det er gjort lite forskning på krillolje og ...

    • Assessing the probability of detection of horizontal gene transfer events in bacterial populations 

      Townsend, Jeffrey P.; Bøhn, Thomas; Nielsen, Kaare Magne (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Experimental approaches to identify horizontal gene transfer (HGT) events of non-mobile DNA in bacteria have typically relied on detection of the initial transformants or their immediate offspring. However, rare HGT events occurring in large and structured populations are unlikely to be detected in a short time frame. Population genetic modeling of the growth dynamics of bacterial genotypes is ...

    • Tn1546 is part of a larger plasmid-encoded genetic unit horizontally disseminated among clonal Enterococcus faecium lineages 

      Sletvold, H; Johnsen, PJ; Wikmark, Odd-Gunnar; Simonsen, Gunnar Skov; Sundsfjord, A; Nielsen, KM (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      o determine the genetic composition of the first VanA-type plasmid (pIP816) reported, which was isolated from a clinical Enterococcus faecium (BM4147) strain in France in 1986, and to reveal the genetic units responsible for the dissemination of the vanA gene cluster by comparisons with current, published and additionally generated vanA-spanning plasmid sequences obtained from a heterogeneous E. ...

    • 3T3 cell lines stably expressing Pax6 or Pax6(5a): a new tool used for identification of common and isoform specific target genes. 

      Kiselev, Yury; Eriksen, Tonje Engevik; Forsdahl, Siri; Nguyen, Lan Huong Thi; Mikkola, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Pax6 and Pax6(5a) are two isoforms of the evolutionary conserved Pax6 gene often co-expressed in specific stochiometric relationship in the brain and the eye during development. The Pax6(5a) protein differs from Pax6 by having a 14 amino acid insert in the paired domain, causing the two proteins to have different DNA binding specificities. Difference in functions during development is proven by the ...

    • Increasing mortality in schizophrenia: Are women at particular risk? A follow-up of 1111 patients admitted during 1980-2006 in Northern Norway 

      Høye, Anne; Jacobsen, Bjarne Koster; Hansen, Vidje (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      A study of mortality for all patients with schizophrenia admitted to the University Hospital of North Norway during 1980-2006 was performed, with a special focus on gender differences and changes in mortality during a period of transition from hospital-based to community-based care. A total of 1111 patients with schizophrenia were included, and the cohort was linked to the Causes of Death Register ...

    • Mucoadhesive liposomal delivery systems : the choice of coating material 

      Karn, Pankaj Ranjan; Vanic, Zeljka; Pepic, Ivan; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Development of liposomal mucoadhesive drug delivery system, which is able to improve the bioavailability of poorly absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating the intimate contact of the delivery system with the absorption membrane. Liposomes containing model drug atenolol were prepared by the modified ethanol injection method. Liposomes ...

    • Risk of diabetes after gestational diabetes and preeclampsia : a registry-based study of 230,000 women in Norway 

      Engeland, Anders; Bjørge, Tone; Daltveit, Anne Kjersti; Skurtveit, Svetlana; Vangen, Siri; Vollset, Stein Emil; Furu, Kari (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      This study aimed to use a population-based Prescription Database to explore later development of diabetes in women registered with gestational diabetes mellitus (GDM) and/or preeclampsia in the Medical Birth Registry of Norway (MBRN) during 2004–8. We used two nationwide Norwegian registries, the Norwegian Prescription Database and the MBRN, to explore the onset of later diabetes after pregnancy ...

    • Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment 

      Basnet, Purusotam; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Oxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer’s disease, etc. Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component ...

    • Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures 

      Johnsen, Pål jarle; Townsend, JP; Bøhn, Thomas; Simonsen, Gunnar Skov; Sundsfjord, arnfinn; Nielsen, Kaare Magne (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      To estimate the relative fitness differences between glycopeptide-resistant Enterococcus faecium (GREF) and glycopeptide-susceptible E. faecium (GSEF) from yearly surveillance data on the occurrence of GREF in Danish poultry farm environments. A population genetic model was adapted to retrospectively estimate the biological fitness cost of acquired resistance. Maximization of a likelihood function ...