Institutt for farmasi: Recent submissions
Now showing items 561-580 of 656
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Uptake and organ distribution of feed introduced plasmid DNA in growing or pregnant rats
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011) -
Sonosensitive dioleoylphosphatidylethanolamine-containing liposomes with prolonged blood circulation time of doxorubicin
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Ultrasound sensitive (sonosensitive liposomes) are drug delivery systems designed for releasing their drug load upon exposure to ultrasound (US). Inclusion of dioleoylphosphatidylethanolamine (DOPE) in liposome membranes was previously shown to induce sonosensitivity. For efficient US mediated drug delivery to solid tumours, a long blood circulation time of the liposomal drug providing high tumour ... -
Advanced delivery system for skin and burns therapy : mupirocin as an antibacterial model drug
(Master thesis; Mastergradsoppgave, 2011-05-20)Trauma to the skin in the form of severe wound, particularly burns, can facilitate colonization of potentially life threatening bacterial infections. To prevent infections of the wounded area, antimicrobial agents are recommended as standard treatment. Topical administration of antimicrobial agents, such as mupirocin, can provide local therapy, while avoiding the risks of systemic administration. ... -
Isolation and characterization of wax esters from Calanus finmarchicus
(Master thesis; Mastergradsoppgave, 2010-06-16)Calanus finmarchicus is a vast resource that until recently have been exploited to a minimal degree only. In the last few years harvesting and processing methods have been developed. There is a large market and great interest in products derived from marine oils. Most of the products today are derived from organisms at a high trophic level, i.e. products derived from cod liver oil. One disadvantage ... -
Structure/activity relationship of alpha-conotoxins targeting GABAB receptor
(Master thesis; Mastergradsoppgave, 2011-06-16)Conotoxins are small disulfide rich peptides derived from the venom of Cone snails. They target different receptors in the nervous system with high selectivity and potency making them valuable as drug leads or drug themselves. One group of conotoxins, α-conotoxins have been shown to have potential as treatment for neuropathic pain. -
Design, synthesis and structural studies of relaxin receptor modulators
(Master thesis; Mastergradsoppgave, 2011-06)The relaxin family of peptides consists of seven structurally related peptides, with a wide variety of biological functions, ranging from involvement in reproductive processes to functions as neuroendocrine modulators. Because of the complex, two-chained structure of the relaxins, and their lack of specificity for the various relaxin family receptors (RXFPs), design of simpler, more selective ... -
Analyser av DKK3 som mulig målgen for Pax6
(Master thesis; Mastergradsoppgave, 2011-06-06)Pax6 og Pax6(5a) er to isoformer av den evolusjonært konserverte transkripsjonsfaktoren som blir uttrykt i blant annet hjernen, øyne, nese og pankreas hos virveldyr under embryoutvikling. Uttrykket av Pax6 vil vedvare hos voksne individer, blant annet i øyne, hjernen og pankreas. Den er viktig for vedlikehold av stamceller, men har også en stor betydning for celle differensiering i mange vev. Aniridia ... -
Evaluation of antiviral prophylaxis of cytomegalovirus in patients receiving liver, kidney or pancreas transplantation
(Master thesis; Mastergradsoppgave, 2011-05-20)Abstract Background– All solid organ transplanted patients are treated with immuno suppression medications to keep the immune system from rejecting the transplanted organ. Unfortunately the suppressed immune system makes the body more exposed for cancer and opportunistic infections. Among the most important viruses that causes one of these opportunistic infections is cytomegalovirus (CMV). A local ... -
Karakterisering av modifiserte antistoffer innen radioimmunoterapi
(Master thesis; Mastergradsoppgave, 2011-05-20)Den prekliniske forskningen i farmasiselskapet Algeta har fokus på utvikling av nye behandlingsmetoder mot kreft ved bruk av målrettet alfa-terapi. I denne problemstillingen inngår bruk av modifiserte antistoffer merket med alfa-emitteren Thorium-227. Modifiseringen innebærer at en kjelator konjugeres til aminosyrene til antistoffet. Dette vil resultere i en heterogen fordeling av antall kjelatorer ... -
A study of the prescribing and administration of immuno-suppressant medication in patients receiving liver, kidney and pancreas transplantation
(Master thesis; Mastergradsoppgave, 2011-05-20)Introduction There is little data on immuno-suppressant administration and prescribing to transplant patients. It was considered a high risk area because errors in prescribing and administration of immuno-suppressants can potentially have serious consequences like graft loss, side effects and even death. The reality was however that the lack of data meant that no one knew whether this was an area ... -
Lipidklasser og fettsyresammensetning i brunpølse (Cucumaria frondosa)
(Master thesis; Mastergradsoppgave, 2011-05-20)Different species of the sea cucumber are a well utilized resource in eastern parts of Asia, but not much used in western parts of the world. The annual harvest of sea cucumbers in Asian waters has been estimated to be over 100,000 tons. This has led to overfishing and decreasing catches. As a result, a demand for new fishing areas has occurred. Different species of sea cucumbers are observed in ... -
Investigation and optimization of liposome formulation for use as drug carrier for the anticancer agent Camptothecin
(Master thesis; Mastergradsoppgave, 2011-06-09)In this thesis, the method development and investigation of different liposomal formulations to incorporate and retain Camptothecin (CPT) is described. CPT is a potent anticancer drug that has shown to be active against a broad spectrum of cancers. However, due to its challenging physicochemical properties, like poor water solubility, severe toxic effects to normal tissues and instability, its ... -
Effect of tumor microenvironment-derived factors on melanoma cell growth and drug-response : an in vitro study in three-dimensional cultures.
(Master thesis; Mastergradsoppgave, 2011-06-07)The incidence rate of malignant melanoma is increasing in Norwegian population as well as worldwide. It’s one of the most aggressive human cancers showing exceptional abilities to metastasize and develop resistance to therapy, and ccurrently there are no effective treatments against metastatic melanoma. Traditionally, melanoma aggressiveness was linked to intrinsic properties of the malignant cells ... -
Development of muds for improved vaginal therapy
(Master thesis; Mastergradsoppgave, 2011-06-01)Bacterial vaginosis is a common cause of vaginitis, condition often treated with oral metronidazole. However, due to unpleasant side effects, patient compliance is often reduced. Vaginal tablet with bioadhesive properties could enable a prolonged residence time and a sustained release of a drug at the site of infection. Vagina as a drug administration site is attractive due to high surface area, ... -
User of ordered mixtures to obtain high dose homogeneity in mini-tablets : studies of orally disintegrating systems for children
(Master thesis; Mastergradsoppgave, 2011-06-01)Studies have shown that homogeneity is higher in ordered mixtures compared to random mixtures. Based on this ordered mixtures should be particularly suitable for the preparation of mini-tablets. The overall aim of the study was to compare the homogeneity of ordered mixtures prepared using different particle size of carrier particles, and test their suitability for preparation of mini-tablets. The ... -
Characterization of the Ion Exchange Reaction Between Propranolol-H+ or K+ with Amberlite IRP 69 Resin by Both, Isothermal Titration Calorimetry and (Flame) Photometric Equilibrium Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009) -
The role of pharmacoepidemiological studies in the market withdrawal of carisoprodol (Somadril®) in Europe.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008) -
A co-operative evaluation of different methods of detecting BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on second-line dasatinib or nilotinib therapy after failure of imatinib
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009) -
Veitrafikkulykker knyttet til forskrivning av legemidler : En registerbasert kohortstudie
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008) -
Repeated dispensing of codeine is associated with high consumption of benzodiazepines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008)