Over the last five years, X-ray structures of CXC chemokine receptor 4 (CXCR4) in complex with three different ligands (the small-molecule antagonist IT1t, the polypeptide antagonist CVX15, and the viral chemokine antagonist vMIP-II) have been released. In addition to the inherent scientific value of these specific X-ray structures, they (i) provide a reliable structural ...

Bruk av nanoteknologi innenfor medisin er økende, og mange nanopartikulære såkalte «drug delivery-systemer» er allerede ute på markedet og enda flere er i pipeline. Det er blant annet stor interesse for bruk av polymeriske miceller, dendrimerer, liposomer og polymeriske nanopartikler som nanobærere for legemidler. Potensialet som ligger i bruk av nanoteknologi er fremdeles ikke fullt utnyttet ...

Several members of the genus Burkholderia are prominent pathogens. Infections caused by these bacteria are difficult to treat because of significant antibiotic resistance. Virtually all Burkholderia species are also resistant to polymyxin, prohibiting use of drugs like colistin that are available for treatment of infections caused by most other drug resistant Gram-negative bacteria. Despite clinical ...

OBJECTIVES: The aim of the study was twofold; 1) to develop a clinical pharmacist-led 12 month lasting follow-up program for patients with established coronary heart disease (CHD) discharged from the University Hospital of North Norway, and 2) to explore the impact of the program with regards to adherence to a medication assessment tool for secondary prevention of CHD and change in biomedical ...

Repetition of a 1978 experiment on the toxicity of glyphosate chemicals in water-flea Daphnia magna showed surprising results. In the 31 years which had passed between the two series of experiments, the toxicity of glyphosate had apparently become 300 times stronger! Further investigation into this enigmatic paradox discloses unfortunate aspects of laboratory researcher cultures as well as fundamental ...

Intragenic recombination leading to mosaic gene formation is known to alter resistance profiles for particular genes and bacterial species. Few studies have examined to what extent aminoglycoside resistance genes undergo intragenic recombination. We screened the GenBank database for mosaic gene formation in homologs of the aph(3′)-IIa (nptII) gene. APH(3′)-IIa inactivates important aminoglycoside ...

Recently we reported on the development of a phospholipid vesicle-based barrier as a medium throughput method for screening of drug permeability. The aim of this present study is to characterize the barrier structure, including an estimation of the amount of phospholipid within it, its storage stability and its stability over various pH ranges found in different parts of the gastrointestinal tract. ...

In-vitro screening for oral absorption has become an essential part of drug discovery and development. Recently, a new phospholipid vesicle-based permeation assay was developed which has shown to satisfyingly predict passive absorption of drugs in humans. The purpose of the current study was to investigate whether the assay may be further developed into a high-throughput tool by automating its ...

Tertiary lymphoid structures are accumulation of lymphocytic cells that may occur in many organs. These structures bear a resemblance to spleen and lymph nodes which are so called secondary lymphoid organs. The formation of such structures can aggravate diseases. These structures have been shown to occur in the kidney when anti-dsDNA antibodies are produced. The development of TLS seems to occur ...

Resveratrol (RES), chemically known as 3,5,4′-trihydroxy-trans-stilbene, is a promising multi-targeted antioxidative and anti-inflammatory natural polyphenol. Preclinical studies showed its biological activities against the pathogens of sexually transmitted diseases causing vaginal inflammation and infections. Due to its low solubility and poor bioavailability, the optimal therapeutic uses are ...