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norskInstitutt for farmasi: Nye registreringer
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Molecular characterization and phylogenetics of Fennoscandian cowpox virus isolates based on the p4c and atip genes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)Background: Cowpox virus (CPXV), a rodent-borne Orthopoxvirus (OPV) that is indigenous to Eurasia can infect humans, cattle, felidae and other animals. Molecular characterization of CPXVs isolated from different geographic locations is important for the understanding of their biology, geographic distribution, classification and evolution. Our aim was to characterize CPXVs isolated from Fennoscandia ... -
Development of targeted liposome drug delivery vehicle
(Master thesis; Mastergradsoppgave, 2012-05-20)Coating of liposomes with polyethylene glycol (PEG) has proven to prolong the circulation time of liposomes in the blood stream. PEG prevents the binding of opsonins and subsequent uptake of the liposomes by mononuclear phagocytic system (MPS). The reduction in clearance of PEGylated liposomes from the circulation improve the bioavailability of the liposomes in the blood and increase the chance of ... -
Liposomes as drug delivery system in mitochondrial targeting
(Master thesis; Mastergradsoppgave, 2012-05-20)The mitochondrion is a subcellular organelle with major functions related to energy production and control of apoptosis. The presence of mitochondria as a subcellular organelle has been known for more than one and a half century. However, only the last decades’ research has discovered their role in ageing and disease pathology, which have led to increasing interest in mitochondria as target for drug ... -
Risk assessment of GM trees in the EU: current regulatory framework and guidance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)The use of genetically modified organisms - their release into the environment, import, and utilisation as food/feed or food/feed ingredients - is regulated in the European Union (EU). For placing onto the market, current legislations require a comprehensive and science-based risk assessment. This risk assessment (RA) is performed by applicants and then evaluated by national authorities in close ... -
Liposomes-in-Hydrogel Delivery System with Mupirocin: In Vitro Antibiofilm Studies and In Vivo Evaluation in Mice Burn Model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Previously, we have proposed mupirocin-in-liposomes-in-hydrogel delivery system as advanced delivery system with the potential in treatment of burns. In the current studies, we evaluated the system for its cytotoxicity, ability to prevent biofilm formation, act on the mature biofilms, and finally determined its potential as wound treatment in in vivo mice burn model.The system was found to be ... -
Clone- and age-dependent toxicity of a glyphosate commercial formulation and its active ingredient in Daphnia magna.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Low levels of glyphosate based herbicide induced significant negative effects on the aquatic invertebrate Daphnia magna. Glyphosate herbicides such as brands of Roundup, are known to be toxic to daphnids. However, published findings on acute toxicity show significant discrepancies and variation across several orders of magnitude. To test the acute effects of both glyphosate and a commercial ... -
Osteopontin is a prognostic biomarker in non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: In a previously published report we characterized the expression of the metastasis-associated proteins S100A4, osteopontin (OPN) and ephrin-A1 in a prospectively collected panel of non-small cell lung cancer (NSCLC) tumors. The aim of the present follow-up study was to investigate the prognostic impact of these potential biomarkers in the same patient cohort. In addition, circulating ... -
Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Introduction: The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in cancer cells through numerous mutations and epigenetic changes. The recent development of inhibitors targeting different components of the PI3K pathway may represent a valuable treatment alternative. However, predicting efficacy of these drugs is challenging, and methods for therapy monitoring are needed. ... -
Characterization of extracellular polymeric matrix, and treatment of Fusobacterium nucleatum and Porphyromonas gingivalis biofilms with DNase I and proteinase K
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: Biofilms are organized communities of microorganisms embedded in a self-produced extracellular polymeric matrix (EPM), often with great phylogenetic variety. Bacteria in the subgingival biofilm are key factors that cause periodontal diseases; among these are the Gram-negative bacteria Fusobacterium nucleatum and Porphyromonas gingivalis. The objectives of this study were to characterize ... -
Identical Miniature Inverted Repeat Transposable Elements Flank Class 1 Integrons in Clinical Isolates of Acinetobacter spp.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Miniature inverted repeat transposable elements (MITEs) have been identified flanking class 1 integrons. We have identified and characterized a 439-bp MITE-like structure in seven Acinetobacter species isolates from Portugal and Brazil. The complete sequence similarity of the elements and flanking regions suggests that MITEs may act as mobilizable vectors for the dissemination of integrons. -
Nanopharmaceuticals for improved topical vaginal delivery: Can they deliver?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Nanopharmaceuticals have the potential to revolutionise medical treatment by permitting the design of more potent, less toxic “smart” therapeutics, ultimately leading to personalised medicine. This review summarises the challenges and potential uses of nanodelivery system for the topical drug therapy of vaginal diseases. The vaginal route of drug administration remains a challenge in the development ... -
The effect of lipid composition and liposome size on the release properties of liposomes-in-hydrogel
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)To study the release of liposome-associated drugs into hydrogels, we designed and synthesized two pH-sensitive rhodamine derivatives to use as model compounds of different lipophilicities. The dyes were fluorescent when in the free form released from liposomes into the chitosan hydrogel, but not when incorporated within liposomes. The effect of liposomal composition, surface charge and vesicle size ... -
Compositional differences in soybeans on the market: glyphosate accumulates in Roundup Ready GM soybeans
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)This article describes the nutrient and elemental composition, including residues of herbicides and pesticides, of 31 soybean batches from Iowa, USA. The soy samples were grouped into three different categories: (i) genetically modified, glyphosate-tolerant soy (GM-soy); (ii) unmodified soy cultivated using a conventional ‘‘chemical’’ cultivation regime; and (iii) unmodified soy cultivated using an ... -
Structure-activity relationship studies of the aromatic positions in cyclopentapeptide CXCR4 antagonists
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)The cyclopentapeptide CXCR4 antagonist FC131 (cyclo(-Arg1-Arg2-2-Nal3-Gly4-D-Tyr5-), 2; 2-Nal = 3-(2-naphthyl)alanine) represents an excellent starting point for development of novel drug-like ligands with therapeutic potential in HIV, cancer, stem-cell mobilization, inflammation, and autoimmune diseases. While the structure–activity relationships for Arg1, Arg2, and Gly4 are well established, less ... -
Pectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Method
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Mucoadhesive liposomes offer a potential for improved residence time of liposomal systems targeting contact with mucosal tissues, such as in buccal, oral, colon, and vaginal drug delivery. Most of the currently available methods rely on the coating of preformed liposomes by various mucoadhesive polymers. The aim of this study was to develop novel mucoadhesive system by the one-pot preparation method. ... -
Metodeutvikling og innledende kompatibilitetsstudie mellom antiinfektiva og Olimel N5E gjennom Y-sett infusjon til barn fra 10 - 50 kg
(Master thesis; Mastergradsoppgave, 2011-06)Total parenteral ernæring (TPN) gis forebyggende eller korrigerende mot feilernæring til pasienter hvor oral eller enteral ernæring vanskelig lar seg gjøre. TPN inneholder glukose, fett og aminorsyrer i tillegg til viktige vitaminer, sporelementer og elektrolytter. TPN er en steril olje-i-vann (o/v) emulsjon, stabilisert ved hjelp av en lecitin-emulgator. Scenario hvor legemiddel og TPN må administreres ... -
Kompatibilitet mellom legemidler og TPN gitt som parallellinfusjon til pediatriske pasienter - metodeutvikling og innledende tester med fem ulike legemidler og én total parenteral ernæringspose
(Master thesis; Mastergradsoppgave, 2011-06)Parallellinfusjon av legemidler og TPN via y-sett kan være ønskelig i tilfeller hvor det er mangel på nok intravenøse innganger. En slik administrering kan gi risiko for inkompatibiliteter som destabilisering av fettemulsjonen eller utfellinger i vannfasen. Det er mangel på kompatibilitetsdata mellom legemidler og TPN-blandinger gitt til barn. I denne studien ble det etablert og validert metoder for ... -
Sosioøkonomisk status og bruk av kosttilskudd blant middelaldrende kvinner – Kvinner og kreft-studien
(Master thesis; Mastergradsoppgave, 2012-06)Bakgrunn: Bruken av kosttilskudd i Norge har hatt en økning over de siste 20 årene, og man har liten oversikt over forbruket. Det har kommet fram av flere amerikanske studier at bruken av kosttilskudd varierer med enkelte sosioøkonomiske variabler, som at kvinner med høyskoleutdannelse bruker mer kosttilskudd enn kvinner med lavere utdannelse. Det er også vist at forbruket av kosttilskudd er høyere ... -
Development of liposomal formulation for green tea catechins targeted for the treatment of vaginal inflammation
(Master thesis; Mastergradsoppgave, 2012-05-20)Green tea catechins are well known for their antioxidative and anti-inflammatory properties. In this connection, catechins are thought to be potential candidates in prevention and treatment of diseases caused by oxidative damage. In addition, catechins have been shown to be effective in the treatment of genital warts. However, they exhibit low bioavailability and poor solubility, which limits their ... -
Legemiddelbruk og bruk av kosttilskudd blant middelaldrende kvinner i Norge – Kvinner og kreft-studien
(Master thesis; Mastergradsoppgave, 2012-05-20)Bakgrunn: Det finnes lite informasjon om bruk og feilbruk av kosttilskudd i Norge. I internasjonale studier er det vist at kronikere er de som bruker mest kosttilskudd, og mange forteller ikke legen om denne bruken. Det finnes rapporterte tilfeller over interaksjoner mellom legemidler og kosttilskudd, men det finnes få studier om dette i Norge. Formål: Formålet med oppgaven er å beskrive forbruket ...
