<p><I>Objectives</I>: The main objective was to investigate Y-site compatibility of intravenous drugs with one standard total parenteral nutrition (TPN) admixture for preterm infants. Since micro-precipitation was observed in the water phase after addition of trace elements, the concentration effect on micro-precipitation formation developed as a sub-goal.</p> <p><I>Methods</I>: Seven drugs ...

Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with cell- or tissue-based permeability profiling. Depending on the composition of the barrier, cell-free permeation systems are classified into two classes including (i) biomimetic barriers which are ...

The aim of this study was to prepare and optimize a novel type of in situ gel-forming solid dosage form (gfSDF) to be used in the treatment of mucosal/skin ulcerations. For this purpose, a simple but reliable syringe-based hot melt/moulding method was employed. Chloramphenicol (antibiotic) and ibuprofen (anti-inflammatory) were chosen as model active pharmaceutical ingredients (APIs) to be loaded ...

In 2010, there were 2839 women and 13 men diagnosed with breast cancer in Norway, which was equivalent to an increase of almost 50% since 1956. The risk of developing breast cancer increases with age, and will affect one in ten women during their lifetime. Despite a substantial increase in the number of early-stage breast cancers detected due to screening-programs, there is still a need for new and ...

<p>I forbindelse med forberedelse til implementering av EU-forordning 1829/2003 i norsk rett har Miljødirektoratet (tidligere Direktoratet for Naturforvalting) bedt Mattilsynet om vurderinger av alle genmodifiserte organismer (GMOer) og avledete produkter som inneholder eller består av GMOer som er godkjent under forordning 1829/2003 eller direktiv 2001/18, og som er godkjent for ett eller flere ...

The Norwegian Environment Agency (NEA) and the Norwegian Food Safety Authority (NFSA) requested the Norwegian Scientific Committee for Food Safety (Vitenskapskomiteen for mattrygghet, VKM) for an opinion of potential risks to biodiversity and agriculture in Norway associated with import of seeds for sowing, and cultivation of insect-resistant and herbicide-tolerant genetically modified maize ...

<p><i>Background</i>: Given time pressures on primary care physicians, utilising pharmacists for chronic disease management is of great interest. However, limited data are available on the current workflow in community pharmacies to guide these discussions.</p> <p><i>Objective</i>: This study aimed to test the feasibility of collecting workflow data from Australian community pharmacies using ...

<p>Antiangiogenic therapy with bevacizumab has shown varying results in breast cancer clinical trials. Identifying robust biomarkers for selecting patients who may benefit from such treatment and for monitoring response is important for the future use of bevacizumab.</p> <p>Two established xenograft models representing basal‐like and luminal‐like breast cancer were used to study bevacizumab ...

Tuberculosis (TB) is an infectious disease that represents a serious global threat, with estimations suggesting that one third of the world’s population is infected. Treating TB today requires long treatment duration and medicines must be administered orally in large doses, which leads to non-compliant patients. CPZEN-45 is a novel anti-TB drug candidate in pre-clinical development, in which pulmonary ...

Breast cancer is the leading cause in cancer deaths among woman worldwide, and one in ten women will experience the disease during their lifetime. Breast cancer accounted for 23% of the total new cancer incidences and 14% of the total cancer deaths in Norway in 2008. One way to potentially improve long-term cancer survival statistics is earlier detection. That includes the discovery and characterization ...