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norskArtikler, rapporter og annet (farmasi): Recent submissions
Now showing items 61-80 of 358
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Biologics: the role of delivery systems in improved therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-19)The beginning of the 21st century saw numerous protein and peptide therapeuticals both on the market and entering the final stages of clinical studies. They represent a new category of biologically originated drugs termed biologics or biologicals. Their main advantages over conventional drugs can be summarized by their high selectivity and potent therapeutic efficacy coupled with limited side ... -
Detection of carbapenemases with a newly developed commercial assay using Matrix Assisted Laser Desorption Ionization-Time of Flight
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-03)This study evaluated the performance of the MBT STAR-Carba kit (Bruker Daltonics), to detect carbapenemase producing Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp. in comparison with the RAPIDEC® CARBA NP test (BioMerieux). MBT STAR-Carba allowed the detection of carbapenemases in Enterobacteriaceae and P. aeruginosa. -
The effect of low-dose naltrexone on medication in inflammatory bowel disease: A quasi experimental before-and-after prescription database study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-27)Background and Aims: Low-dose naltrexone [LDN] is a controversial off-label treatment used by many Crohn’s disease [CD] and ulcerative colitis [UC] patients. A small number of preliminary studies indicate that LDN might be beneficial in CD, but evidence is too scarce to demonstrate efficacy. We sought to examine whether initiation of LDN therapy by patients with inflammatory bowel disease [IBD] ... -
Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-24)Objectives: To examine performance of EUCAST disc diffusion and supplementary MIC methods for detection of Enterobacteriaceae with reduced susceptibility to meropenem using EUCAST screening recommendations.<p> <p>Methods: Sixty-one Nordic laboratories delivered data on EUCAST disc diffusion (n " 61), semi-automated meropenem MIC (n " 23; VITEK2, n " 20 and Phoenix, n " 3) and gradient meropenem ... -
Detection of DHCMT long-term metabolite glucuronides with LC-MSMS as an alternative approach to conventional GC-MSMS analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-17)Dehydrochloromethyltestosterone (DHCMT) is one of the most detected illicit used anabolic–androgenic steroids in professional sports. Therefore, a fast and accurate analysis of this substance is of great importance for a constructive fight against doping abuse. The conventional method for the analysis of this drug, GC-MSMS, is very sensitive and selective but also very time- and resource-consuming. ... -
Drug loading to mesoporous silica carriers by solvent evaporation: A comparative study of amorphization capacity and release kinetics
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-08)The sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement for this challenging group of substances. However, the success of this approach for a particular API depends on an array of factors including the properties of the porous carrier, the loading method, or the attempted ... -
Self-medication Behavior with antibiotics: a national cross-sectional survey in Sri Lanka
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-14)<b><p>Background</b> Antibiotic self-medication is common in low- and middle-income countries. This study aimed to evaluate the Sri Lankan public’s knowledge about and attitudes toward antibiotic use and self-medication, and factors associated with self-medication. <b><p>Methods</b> A national cross-sectional, interviewer-administered, survey of a random household sample (N = 1100) was ... -
Influensavaksine, en spørreundersøkelse blant apotekkunder
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-06)<p><i>Hensikt: </i>Å kartlegge apotekkunders erfaring med og vilje til å ta influensavaksine, samt utvalgte faktorers sammenheng med vaksineringsvilje, inkludert sannsynlighet for å ta covid-19-vaksine. <p><i>Materiale og metode: </i>Masterstudenter i apotekpraksis intervjuet apotekkunder ved hjelp av spørreskjema. Spørsmålene omfattet erfaring med influensavaksine, risikogruppestatus, vaksineringsvilje, ... -
Perspectives for systems biology in the management of tuberculosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-25)Standardised management of tuberculosis may soon be replaced by individualised, precision medicineguided therapies informed with knowledge provided by the field of systems biology. Systems biology is a rapidly expanding field of computational and mathematical analysis and modelling of complex biological systems that can provide insights into mechanisms underlying tuberculosis, identify novel ... -
Integrating the clinical pharmacist into the emergency department interdisciplinary team: A study protocol for a multicentre trial applying a non-randomised stepped-wedge study design
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)Introduction: The ‘emergency department (ED) pharmacist’ is an integrated part of the ED interdisciplinary team in many countries, which have shown to improve medication safety and reduce costs related to hospitalisations. In Norway, few EDs are equipped with ED pharmacists, and research describing effects on patients has not been conducted. The aim of this study is to investigate the impact ... -
Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-24)Oncolytic peptides represent a novel, promising cancer treatment strategy with activity in a broad spectrum of cancer entities, including colorectal cancer (CRC). Cancer cells are killed by immunogenic cell death, causing long-lasting anticancer immune responses, a feature of particular interest in non-immunogenic CRC. Oncolytic peptides DTT-205 and DTT-304 were administered by intratumoral injection ... -
Drug-Drug-Gene Interactions: A Call for Clinical Consideration
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-18)It is widely accepted that both comedications and genetic factors may contribute to variation of drug response. Clinical decision support systems increasingly consider recommendations on drug– drug interactions (DDIs) during electronic prescribing, and some guidelines on drug–gene-interactions (DGI) have been implemented in drug labels. Potentially synergistically or antagonistically ... -
Implementation of a shared medication list in primary care - a controlled pre-post study of medication discrepancies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)Background: Access to medicines information is important when treating patients, yet discrepancies in medication records are common. Many countries are developing shared medication lists across health care providers. These systems can improve information sharing, but little is known about how they afect the need for medication reconciliation. The aim of this study was to investigate whether an ... -
Electrospinning of chloramphenicol-containing nanofibrous dressings for treatment of chronic wounds
(Conference object; Konferansebidrag, 2021-03-10)<p><i>Background</i> An efficient treatment is crucial to overcome the delayed healing process and high infection rate in chronic wounds. Nanofibrous dressings, having a nano‐sized fiber structure, can enhance cell ingrowth and support the healing process. In addition, nanofibers can deliver active ingredients e.g. antibiotics into the wound to treat wound infection. By incorporating broad‐spectrum ... -
An introduction to network analysis for studies of medication use
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-29)Background - Network Analysis (NA) is a method that has been used in various disciplines such as Social sciences and Ecology for decades. So far, NA has not been used extensively in studies of medication use. Only a handful of papers have used NA in Drug Prescription Networks (DPN). We provide an introduction to NA terminology alongside a guide to creating and extracting results from the medication ... -
Intervention fidelity and process outcomes of the IMMENSE study, a pharmacist-led interdisciplinary intervention to improve medication safety in older hospitalized patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-21)What is known and Objective - The majority of hospitalized older patients experience medication-related problems (MRPs), and there is a call for interventions to solve MRPs and improve clinical outcomes like medical visits. The IMMENSE study is a randomized controlled trial investigating the impact of a pharmacist-led interdisciplinary intervention on emergency medical visits. Its multistep intervention ... -
A high-throughput multiplexing and selection strategy to complete bacterial genomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-09)Background: Bacterial whole-genome sequencing based on short-read technologies often results in a draft assembly formed by contiguous sequences. The introduction of long-read sequencing technologies permits those contiguous sequences to be unambiguously bridged into complete genomes. However, the elevated costs associated with long-read sequencing frequently limit the number of bacterial isolates ... -
The Norwegian Society for Pharmacoepidemiology
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)The Norwegian Society for Pharmacoepidemiology (NFFE) is a multidisciplinary, nation-wide network of professionals involved in the field of pharmacoepidemiology. Pharmacoepidemiology is the science that bridges epidemiologic methodology with clinical pharmacology and clinical pharmacy, for studying the use, effectiveness, value and safety of pharmaceuticals1 . The foundation of NFFE took into ... -
Antibacterial use by birth year and birth season in children 0-2 years in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)Introduction: Consumption of antibacterials in children follows seasonal cycles, and time to first treatment depends on birth season. The aim of this study was to describe dispensing rate, one-year periodic prevalence, and age at first prescription in children aged 0-2 years in Norway. Methods: We used data from the Norwegian prescription database and included all dispensed prescriptions on systemic ... -
Integrating the clinical pharmacist into the emergency department interdisciplinary team: a study protocol for a multicentre trial applying a non-randomised stepped-wedge study design
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)Introduction - The ‘emergency department (ED) pharmacist’ is an integrated part of the ED interdisciplinary team in many countries, which have shown to improve medication safety and reduce costs related to hospitalisations. In Norway, few EDs are equipped with ED pharmacists, and research describing effects on patients has not been conducted. The aim of this study is to investigate the impact of ...
